| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-123 |
Sentence |
denotes |
The G51S purine nucleoside phosphorylase polymorphism is associated with cognitive decline in Alzheimer's disease patients. |
| T2 |
124-328 |
Sentence |
denotes |
Alzheimer's disease (AD) is a polygenic and multifactorial complex disease, whose etiopathology is still unclear, however several genetic factors have shown to increase the risk of developing the disease. |
| T3 |
329-400 |
Sentence |
denotes |
Purine nucleotides and nucleosides play an important role in the brain. |
| T4 |
401-545 |
Sentence |
denotes |
Besides their role in neurotransmission and neuromodulation, they are involved in trophic factor release, apoptosis, and inflammatory responses. |
| T5 |
546-656 |
Sentence |
denotes |
These mediators may also have a pivotal role in the control of neurodegenerative processes associated with AD. |
| T6 |
657-968 |
Sentence |
denotes |
In this report the distribution of the exonic G/A single nucleotide polymorphism (SNP) in purine nucleoside phosphorylase (PNP) gene, resulting in the amino acid substitution serine to glycine at position 51 (G51S), was investigated in a large population of AD patients (n=321) and non-demented control (n=208). |
| T7 |
969-1051 |
Sentence |
denotes |
The PNP polymorphism distribution was not different between patients and controls. |
| T8 |
1052-1216 |
Sentence |
denotes |
The polymorphism distribution was also analyzed in AD patients stratified according to differential progressive rate of cognitive decline during a 2-year follow-up. |
| T9 |
1217-1397 |
Sentence |
denotes |
An increased representation of the PNP AA genotype was observed in AD patients with fast cognitive deterioration in comparison with that from patients with slow deterioration rate. |
| T10 |
1398-1627 |
Sentence |
denotes |
Our findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in AD patients, highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder. |
