LitCoin-sentences  

PubMed:16867021 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Antipsychotic-like profile of thioperamide, a selective H3-receptor antagonist in mice.
T2 88-209 Sentence denotes Experimental and clinical evidence points to a role of central histaminergic system in the pathogenesis of schizophrenia.
T3 210-421 Sentence denotes The present study was designed to study the effect of histamine H(3)-receptor ligands on neuroleptic-induced catalepsy, apomorphine-induced climbing behavior and amphetamine-induced locomotor activities in mice.
T4 422-744 Sentence denotes Catalepsy was induced by haloperidol (2 mg/kg p.o.), while apomorphine (1.5 mg/kg s.c.) and amphetamine (2 mg/kg s.c.) were used for studying climbing behavior and locomotor activities, respectively. (R)-alpha-methylhistamine (RAMH) (5 microg i.c.v.) and thioperamide (THP) (15 mg/kg i.p.), per se did not cause catalepsy.
T5 745-894 Sentence denotes Administration of THP (3.75, 7.5 and 15 mg/kg i.p.) 1 h prior to haloperidol resulted in a dose-dependent increase in the catalepsy times (P < 0.05).
T6 895-988 Sentence denotes However, pretreatment with RAMH significantly reversed such an effect of THP (15 mg/kg i.p.).
T7 989-1150 Sentence denotes RAMH per se showed significant reduction in locomotor time, distance traveled and average speed but THP (15 mg/kg i.p.) per se had no effect on these parameters.
T8 1151-1290 Sentence denotes On amphetamine-induced hyperactivity, THP (3.75 and 7.5 mg/kg i.p.) reduced locomotor time, distance traveled and average speed (P < 0.05).
T9 1291-1394 Sentence denotes Pretreatment with RAMH (5 microg i.c.v.) could partially reverse such effects of THP (3.75 mg/kg i.p.).
T10 1395-1476 Sentence denotes Climbing behavior induced by apomorphine was reduced in animals treated with THP.
T11 1477-1535 Sentence denotes Such an effect was, however, reversed in presence of RAMH.
T12 1536-1720 Sentence denotes THP exhibited an antipsychotic-like profile by potentiating haloperidol-induced catalepsy, reducing amphetamine-induced hyperactivity and reducing apomorphine-induced climbing in mice.
T13 1721-1818 Sentence denotes Such effects of THP were reversed by RAMH indicating the involvement of histamine H(3)-receptors.
T14 1819-1929 Sentence denotes Findings suggest a potential for H(3)-receptor antagonists in improving the refractory cases of schizophrenia.