LitCoin-sentences  

PubMed:15897593 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-131 Sentence denotes Dexrazoxane protects against myelosuppression from the DNA cleavage-enhancing drugs etoposide and daunorubicin but not doxorubicin.
T2 132-140 Sentence denotes PURPOSE:
T3 141-372 Sentence denotes The anthracyclines daunorubicin and doxorubicin and the epipodophyllotoxin etoposide are potent DNA cleavage-enhancing drugs that are widely used in clinical oncology; however, myelosuppression and cardiac toxicity limit their use.
T4 373-471 Sentence denotes Dexrazoxane (ICRF-187) is recommended for protection against anthracycline-induced cardiotoxicity.
T5 472-492 Sentence denotes EXPERIMENTAL DESIGN:
T6 493-672 Sentence denotes Because of their widespread use, the hematologic toxicity following coadministration of dexrazoxane and these three structurally different DNA cleavage enhancers was investigated:
T7 673-851 Sentence denotes Sensitivity of human and murine blood progenitor cells to etoposide, daunorubicin, and doxorubicin +/- dexrazoxane was determined in granulocyte-macrophage colony forming assays.
T8 852-1053 Sentence denotes Likewise, in vivo, B6D2F1 mice were treated with etoposide, daunorubicin, and doxorubicin, with or without dexrazoxane over a wide range of doses: posttreatment, a full hematologic evaluation was done.
T9 1054-1062 Sentence denotes RESULTS:
T10 1063-1358 Sentence denotes Nontoxic doses of dexrazoxane reduced myelosuppression and weight loss from daunorubicin and etoposide in mice and antagonized their antiproliferative effects in the colony assay; however, dexrazoxane neither reduced myelosuppression, weight loss, nor the in vitro cytotoxicity from doxorubicin.
T11 1359-1370 Sentence denotes CONCLUSION:
T12 1371-1678 Sentence denotes Although our findings support the observation that dexrazoxane reduces neither hematologic activity nor antitumor activity from doxorubicin clinically, the potent antagonism of daunorubicin activity raises concern; a possible interference with anticancer efficacy certainly would call for renewed attention.
T13 1679-1790 Sentence denotes Our data also suggest that significant etoposide dose escalation is perhaps possible by the use of dexrazoxane.
T14 1791-1978 Sentence denotes Clinical trials in patients with brain metastases combining dexrazoxane and high doses of etoposide is ongoing with the aim of improving efficacy without aggravating hematologic toxicity.
T15 1979-2105 Sentence denotes If successful, this represents an exciting mechanism for pharmacologic regulation of side effects from cytotoxic chemotherapy.