LitCoin-sentences  

PubMed:15599941 JSONTXT 26 Projects

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Id Subject Object Predicate Lexical cue
T1 0-133 Sentence denotes Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer.
T2 134-145 Sentence denotes BACKGROUND:
T3 146-269 Sentence denotes Recent data has suggested that polymorphisms in the prostate specific antigen (PSA) may increase prostate cancer (PC) risk.
T4 270-359 Sentence denotes The PSA gene contains a G/A substitution in the androgen response element (ARE) 1 region.
T5 360-526 Sentence denotes The androgen receptor (AR) gene has polymorphic regions containing variable length glutamine and glycine repeats and these are believed to be associated with PC risk.
T6 527-644 Sentence denotes The effect on PC risks from PSA polymorphisms alone and synergistically with the AR gene was examined in this report.
T7 645-653 Sentence denotes METHODS:
T8 654-792 Sentence denotes One hundred PC patients and an age matched cohort of 79 benign prostate hyperplasia and 67 population controls were entered in this study.
T9 793-867 Sentence denotes DNA was extracted from blood and PSA/ARE promoter region amplified by PCR.
T10 868-947 Sentence denotes PCR products were cut with Nhe 1 restriction enzyme to distinguish G/A alleles.
T11 948-1034 Sentence denotes AR/CAG and GGC repeat length was detected by automated fluorescence from PCR products.
T12 1035-1043 Sentence denotes RESULTS:
T13 1044-1202 Sentence denotes We found a significantly higher PSA/GG distribution in PC (30%) than either benign prostatic hyperplasia (BPH) (18%) or population controls (16%) (P = 0.025).
T14 1203-1309 Sentence denotes Furthermore the GG distribution within cases was even greater in younger men (< 65 years; 42%; P = 0.012).
T15 1310-1508 Sentence denotes Additionally, when PSA genotype was cross classified with CAG repeat, significantly more cases than both BPH and population controls were observed to have a short (< 22) CAG/GG genotype (P = 0.006).
T16 1509-1521 Sentence denotes CONCLUSIONS:
T17 1522-1633 Sentence denotes Our results indicate that the PSA/ARE GG genotype confers an increased risk of PC especially among younger men.
T18 1634-1788 Sentence denotes Moreover, we confirm previous results that a short glutamine repeat in conjunction with GG genotype significantly increases the risk of malignant disease.