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PubMed:7554315 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
T1 0-149 Sentence denotes Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
T2 150-160 Sentence denotes OBJECTIVE:
T2 150-160 Sentence denotes OBJECTIVE:
T3 161-262 Sentence denotes Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
T3 161-262 Sentence denotes Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
T4 263-432 Sentence denotes We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
T4 263-432 Sentence denotes We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
T5 433-440 Sentence denotes DESIGN:
T5 433-440 Sentence denotes DESIGN:
T6 441-730 Sentence denotes The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
T6 441-730 Sentence denotes The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
T7 731-740 Sentence denotes SUBJECTS:
T7 731-740 Sentence denotes SUBJECTS:
T8 741-855 Sentence denotes Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
T8 741-855 Sentence denotes Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
T9 856-919 Sentence denotes The control group consisted of 24 healthy laboratory employees.
T9 856-919 Sentence denotes The control group consisted of 24 healthy laboratory employees.
T10 920-933 Sentence denotes MEASUREMENTS:
T10 920-933 Sentence denotes MEASUREMENTS:
T11 934-1083 Sentence denotes The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
T11 934-1083 Sentence denotes The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
T12 1084-1092 Sentence denotes RESULTS:
T12 1084-1092 Sentence denotes RESULTS:
T13 1093-1220 Sentence denotes Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
T13 1093-1220 Sentence denotes Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
T14 1221-1340 Sentence denotes In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
T14 1221-1340 Sentence denotes In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
T15 1341-1478 Sentence denotes In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
T15 1341-1478 Sentence denotes In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
T16 1479-1553 Sentence denotes However, a decreased affinity of the glucocorticoid receptor was observed.
T16 1479-1553 Sentence denotes However, a decreased affinity of the glucocorticoid receptor was observed.
T17 1554-1697 Sentence denotes There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
T17 1554-1697 Sentence denotes There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
T18 1698-1812 Sentence denotes There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
T18 1698-1812 Sentence denotes There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
T19 1813-1825 Sentence denotes CONCLUSIONS:
T19 1813-1825 Sentence denotes CONCLUSIONS:
T20 1826-1941 Sentence denotes There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
T20 1826-1941 Sentence denotes There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
T21 1942-2310 Sentence denotes The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.
T21 1942-2310 Sentence denotes The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.