> top > projects > Inflammaging > docs > PubMed:29323748 > annotations
Inflammaging  

PubMed:29323748 JSONTXT 28 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β-catenin signaling pathway.
T1 0-126 Sentence denotes The gain-of-function mutation E76K in SHP2 promotes CAC tumorigenesis and induces EMT via the Wnt/β-catenin signaling pathway.
T2 127-196 Sentence denotes SHP2 is encoded by the protein tyrosine phosphatase 11 (Ptpn11) gene.
T2 127-196 Sentence denotes SHP2 is encoded by the protein tyrosine phosphatase 11 (Ptpn11) gene.
T3 197-322 Sentence denotes Several gain-of-function (GOF) mutations in Ptpn11 have been identified in human hematopoietic malignancies and solid tumors.
T3 197-322 Sentence denotes Several gain-of-function (GOF) mutations in Ptpn11 have been identified in human hematopoietic malignancies and solid tumors.
T4 323-425 Sentence denotes In addition, the mutation rate for SHP2 is the highest for colorectal cancer (CRC) among solid tumors.
T4 323-425 Sentence denotes In addition, the mutation rate for SHP2 is the highest for colorectal cancer (CRC) among solid tumors.
T5 426-613 Sentence denotes The E76K GOF mutation is the most common and active SHP2 mutation; however, the pathogenic effects and function of this mutation in CRC tumor progression have not been well characterized.
T5 426-613 Sentence denotes The E76K GOF mutation is the most common and active SHP2 mutation; however, the pathogenic effects and function of this mutation in CRC tumor progression have not been well characterized.
T6 614-756 Sentence denotes The Wnt/β-catenin (CTNNB1) signaling pathway is crucial for CRC, and excessive activation of this pathway has been observed in several tumors.
T6 614-756 Sentence denotes The Wnt/β-catenin (CTNNB1) signaling pathway is crucial for CRC, and excessive activation of this pathway has been observed in several tumors.
T7 757-976 Sentence denotes We used Ptpn11E76K conditional knock-in mice to study this GOF mutation in colitis-associated CRC (CAC) and used the CRC cell lines HT29 and HCT116 to determine the relationship between SHP2 and Wnt/β-catenin signaling.
T7 757-976 Sentence denotes We used Ptpn11E76K conditional knock-in mice to study this GOF mutation in colitis-associated CRC (CAC) and used the CRC cell lines HT29 and HCT116 to determine the relationship between SHP2 and Wnt/β-catenin signaling.
T8 977-1080 Sentence denotes Ptpn11E76K conditional knock-in mice exhibited aggravated inflammation and increased CAC tumorigenesis.
T8 977-1080 Sentence denotes Ptpn11E76K conditional knock-in mice exhibited aggravated inflammation and increased CAC tumorigenesis.
T9 1081-1256 Sentence denotes In vitro, SHP2E76K and SHP2WT promoted malignant biological behaviors of CRC cells and induced epithelial-mesenchymal transition (EMT) via the Wnt/β-catenin signaling pathway.
T9 1081-1256 Sentence denotes In vitro, SHP2E76K and SHP2WT promoted malignant biological behaviors of CRC cells and induced epithelial-mesenchymal transition (EMT) via the Wnt/β-catenin signaling pathway.
T10 1257-1374 Sentence denotes Together, our results showed that SHP2E76K acts as an oncogene that promotes the tumorigenesis and metastasis of CRC.
T10 1257-1374 Sentence denotes Together, our results showed that SHP2E76K acts as an oncogene that promotes the tumorigenesis and metastasis of CRC.