CORD-19:16a812de72963ceda960a168236e8dbe91832d45 / 56776-57704 6 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T126 | 313-633 | Epistemic_statement | denotes | Treatment with β-methylcyclodextrin, a cholesterol-chelating compound that effectively destroys lipid raft structure, prevented rHIgM22-induced survival signaling, suggesting that perhaps redistribution or aggregation of lipid raft domains is necessary for antibody-mediated signal transduction (Howe et al., 2004) (Fig. |
| T127 | 640-928 | Epistemic_statement | denotes | This hypothesis is further supported by evidence that monovalent forms of sHIgM22 are unable to elicit remyelination or calcium signaling , suggesting that multivalency, and therefore oligomerization of cognate antigen, is necessary for the function of remyelination-promoting antibodies. |