SeeDev-binary@ldeleger:SeeDev-binary-17999645-4 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/SeeDev-binary@ldeleger/sourceid/SeeDev-binary-17999645-4","sourcedb":"SeeDev-binary@ldeleger","sourceid":"SeeDev-binary-17999645-4","text":"The interaction of AGL15 with members of the SIN3/HDAC1 complex suggests a mechanism that could explain its function as a transcriptional repressor in planta\nHistone deacetylase (HDAC) enzymes remove acetyl groups from histones, and hypoacetylation results in a decrease in the space between the nucleosome and the DNA that is wrapped around it. Tighter wrapping of the DNA diminishes accessibility for transcription factors, leading to transcriptional repression (for a review, see de Ruijter et al., 2003). SIN3-associated proteins (SAP18 and SAP30) have been hypothesized to stabilize the SIN3–HDAC interaction (discussed by Silverstein and Ekwall, 2005). SAP18, like other core members of the SIN3/HDAC1 complex, is not believed to directly associate with the chromatin (reviewed by Silverstein and Ekwall, 2005), but does interact with sequence-specific DNA binding proteins (e.g., Espinas et al., 2000; Song and Galbraith, 2006; Zhu and Hanes, 2000; this study), implicating it as a bridge protein connecting the core SIN3/HDAC1 complex targeted genes.\nWhen directed to regulatory regions of genes, SAP18 or other components of the HDAC complex lead to repression of gene expression (Song and Galbraith, 2006; Song et al., 2005; Wu et al., 2000; Yang et al., 1996; Zhang et al., 1997; Zhu et al., 2001). We demonstrated that SAP18 is able to associate with DNA-bound AGL15 in vitro, but is not able to directly interact with a strong AGL15 binding site (Figure 7). Likewise, SAP18 also interacts with DNA-bound ERF3 in vitro, but not with the ERF3 binding site (Song and Galbraith, 2006).\n","tracks":[{"project":"bionlp-ost-19-SeeDev-bin-dev","denotations":[{"id":"T1","span":{"begin":19,"end":24},"obj":"Protein"},{"id":"T2","span":{"begin":45,"end":63},"obj":"Protein_Complex"},{"id":"T3","span":{"begin":45,"end":49},"obj":"Protein"},{"id":"T4","span":{"begin":50,"end":55},"obj":"Protein"},{"id":"T5","span":{"begin":148,"end":157},"obj":"Genotype"},{"id":"T6","span":{"begin":158,"end":177},"obj":"Protein_Family"},{"id":"T7","span":{"begin":179,"end":183},"obj":"Protein_Family"},{"id":"T8","span":{"begin":509,"end":533},"obj":"Protein_Family"},{"id":"T9","span":{"begin":509,"end":513},"obj":"Protein"},{"id":"T10","span":{"begin":535,"end":540},"obj":"Protein"},{"id":"T11","span":{"begin":545,"end":550},"obj":"Protein"},{"id":"T12","span":{"begin":592,"end":601},"obj":"Protein_Complex"},{"id":"T13","span":{"begin":592,"end":596},"obj":"Protein"},{"id":"T14","span":{"begin":597,"end":601},"obj":"Protein_Family"},{"id":"T15","span":{"begin":659,"end":664},"obj":"Protein"},{"id":"T16","span":{"begin":697,"end":715},"obj":"Protein_Complex"},{"id":"T17","span":{"begin":697,"end":701},"obj":"Protein"},{"id":"T18","span":{"begin":702,"end":707},"obj":"Protein"},{"id":"T19","span":{"begin":1024,"end":1042},"obj":"Protein_Complex"},{"id":"T20","span":{"begin":1024,"end":1028},"obj":"Protein"},{"id":"T21","span":{"begin":1029,"end":1034},"obj":"Protein"},{"id":"T22","span":{"begin":1105,"end":1110},"obj":"Protein"},{"id":"T23","span":{"begin":1138,"end":1150},"obj":"Protein_Complex"},{"id":"T24","span":{"begin":1138,"end":1142},"obj":"Protein_Family"},{"id":"T25","span":{"begin":1331,"end":1336},"obj":"Protein"},{"id":"T26","span":{"begin":1373,"end":1378},"obj":"Protein"},{"id":"T27","span":{"begin":1379,"end":1387},"obj":"Environmental_Factor"},{"id":"T28","span":{"begin":1440,"end":1459},"obj":"Protein_Domain"},{"id":"T29","span":{"begin":1440,"end":1445},"obj":"Protein"},{"id":"T30","span":{"begin":1481,"end":1486},"obj":"Protein"},{"id":"T31","span":{"begin":1517,"end":1521},"obj":"Protein"},{"id":"T32","span":{"begin":1522,"end":1530},"obj":"Environmental_Factor"},{"id":"T33","span":{"begin":1549,"end":1566},"obj":"Protein_Domain"},{"id":"T34","span":{"begin":1549,"end":1553},"obj":"Protein"},{"id":"E1","span":{"begin":19,"end":24},"obj":"Interacts_With"},{"id":"E2","span":{"begin":1481,"end":1486},"obj":"Interacts_With"},{"id":"E3","span":{"begin":1481,"end":1486},"obj":"Binds_To"},{"id":"E4","span":{"begin":1331,"end":1336},"obj":"Binds_To"},{"id":"E5","span":{"begin":179,"end":183},"obj":"Has_Sequence_Identical_To"},{"id":"E6","span":{"begin":535,"end":540},"obj":"Is_Member_Of_Family"},{"id":"E7","span":{"begin":545,"end":550},"obj":"Is_Member_Of_Family"},{"id":"E8","span":{"begin":1522,"end":1530},"obj":"Interacts_With"},{"id":"E9","span":{"begin":1379,"end":1387},"obj":"Interacts_With"},{"id":"E10","span":{"begin":1522,"end":1530},"obj":"Interacts_With"},{"id":"E11","span":{"begin":1379,"end":1387},"obj":"Interacts_With"},{"id":"E12","span":{"begin":19,"end":24},"obj":"Exists_In_Genotype"},{"id":"E13","span":{"begin":45,"end":63},"obj":"Exists_In_Genotype"},{"id":"E14","span":{"begin":1522,"end":1530},"obj":"Is_Linked_To"},{"id":"E15","span":{"begin":1522,"end":1530},"obj":"Is_Linked_To"}],"relations":[{"id":"R1","pred":"Agent","subj":"E1","obj":"T1"},{"id":"R2","pred":"Target","subj":"E1","obj":"T2"},{"id":"R3","pred":"Agent","subj":"E2","obj":"T30"},{"id":"R4","pred":"Target","subj":"E2","obj":"T31"},{"id":"R5","pred":"Functional_Molecule","subj":"E3","obj":"T30"},{"id":"R6","pred":"Molecule","subj":"E3","obj":"T33"},{"id":"R7","pred":"Functional_Molecule","subj":"E4","obj":"T25"},{"id":"R8","pred":"Molecule","subj":"E4","obj":"T28"},{"id":"R9","pred":"Element1","subj":"E5","obj":"T7"},{"id":"R10","pred":"Element2","subj":"E5","obj":"T6"},{"id":"R11","pred":"Element","subj":"E6","obj":"T10"},{"id":"R12","pred":"Family","subj":"E6","obj":"T8"},{"id":"R13","pred":"Element","subj":"E7","obj":"T11"},{"id":"R14","pred":"Family","subj":"E7","obj":"T8"},{"id":"R15","pred":"Agent","subj":"E8","obj":"T32"},{"id":"R16","pred":"Target","subj":"E8","obj":"T30"},{"id":"R17","pred":"Agent","subj":"E9","obj":"T27"},{"id":"R18","pred":"Target","subj":"E9","obj":"T25"},{"id":"R19","pred":"Agent","subj":"E10","obj":"T32"},{"id":"R20","pred":"Target","subj":"E10","obj":"T33"},{"id":"R21","pred":"Agent","subj":"E11","obj":"T27"},{"id":"R22","pred":"Target","subj":"E11","obj":"T28"},{"id":"R23","pred":"Molecule","subj":"E12","obj":"T1"},{"id":"R24","pred":"Genotype","subj":"E12","obj":"T5"},{"id":"R25","pred":"Molecule","subj":"E13","obj":"T2"},{"id":"R26","pred":"Genotype","subj":"E13","obj":"T5"},{"id":"R27","pred":"Agent1","subj":"E14","obj":"T32"},{"id":"R28","pred":"Agent2","subj":"E14","obj":"T30"},{"id":"R29","pred":"Agent1","subj":"E15","obj":"T32"},{"id":"R30","pred":"Agent2","subj":"E15","obj":"T31"}],"attributes":[{"subj":"T1","pred":"source","obj":"bionlp-ost-19-SeeDev-bin-dev"},{"subj":"T2","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