SeeDev-binary@ldeleger:SeeDev-binary-11573014-3 JSONTXT

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Possesses a B3 Domain Characteristic of Transcription Factors.\nOur findings that the LEC2 gene encodes a B3 domain protein\n(Fig. 3) and is expressed primarily during embryogenesis (Fig. 4)\nsuggest that it, like LEC1 and FUS3, is a transcriptional regulator of\nseed development. The B3 domain is an ≈120-amino acid residue region\ndefined originally as the third basic region of maize VP1, which shares\nthe largest contiguous block of sequence identity with its ortholog,\nArabidopsis ABI3 (10). Subsequently, this domain was\nidentified in other plant proteins, such as AUXIN RESPONSE FACTOR1 (34)\nand RELATED TO ABI3/VP1 (32). Many proteins containing B3 domains,\nincluding ABI3/VP1, FUS3, and AUXIN RESPONSE FACTOR1, function as\ntranscription factors (20, 33, 34). The B3 domain is responsible, at\nleast in part, for the DNA-binding activity of ABI3/VP1 and RELATED\nTO ABI3/VP1 (32, 37, 38). To our knowledge, the B3 DNA-binding domain\nis unique to plants.\nMaximum parsimony analysis (39) of the B3 domains of 48 predicted\nArabidopsis proteins suggests that LEC2, FUS3, and ABI3\nconstitute one class, perhaps indicating their common origin (S.L.S.\nand J.J.H., unpublished results). All three genes are expressed\nprimarily during embryogenesis and are required genetically for the\ncompletion of normal seed development. Although they all play roles in\nseed development, their specific functions have diverged. ABI3 is a\ntranscription factor that operates primarily during the maturation\nphase, whereas LEC2 and FUS3 are LEAFY COTYLEDON proteins required for\nprocesses during both the morphogenesis and maturation phases.\n"}