Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-109 |
Sentence |
denotes |
[Treatment of chronic Wilson's disease in 2 patients using plasmapheresis--clinico-biochemical observations]. |
TextSentencer_T2 |
110-214 |
Sentence |
denotes |
Lecenje dva hronicna bolesnika od Vilsonove bolesti pomoću plazmafereze--klinicko-biohemijska zapazanja. |
TextSentencer_T3 |
215-228 |
Sentence |
denotes |
INTRODUCTION: |
TextSentencer_T4 |
229-359 |
Sentence |
denotes |
The introduction of penicillamine in the treatment of Wilson's disease (hepatolenticular degeneration) was a historical event [1]. |
TextSentencer_T5 |
360-460 |
Sentence |
denotes |
D-pericillamine (d-PAM) showed some potential side effects such as myasthenia, kidney toxicity, etc. |
TextSentencer_T6 |
461-563 |
Sentence |
denotes |
In previous decade the treatment of Wilson's disease (WD) with zinc sulphate started successfully [4]. |
TextSentencer_T7 |
564-724 |
Sentence |
denotes |
Danks [7] described the use of exchanged transfusions, peritoneal dialysis and plasmapheresis in the treatment of young patients with WD in acute liver failure. |
TextSentencer_T8 |
725-767 |
Sentence |
denotes |
These patients had acute copper poisoning. |
TextSentencer_T9 |
768-810 |
Sentence |
denotes |
The results of this study were beneficial. |
TextSentencer_T10 |
811-832 |
Sentence |
denotes |
MATERIAL AND METHODS: |
TextSentencer_T11 |
833-948 |
Sentence |
denotes |
Therapeutic plasmapheresis (PF) has been used in many diseases in which immunological mechanisms are proved [8, 9]. |
TextSentencer_T12 |
949-1043 |
Sentence |
denotes |
We started with using PF in the treatment of two young chronic patients with Wilson's disease. |
TextSentencer_T13 |
1044-1151 |
Sentence |
denotes |
The clinical picture of patients became worse, probably due to the decrease in cupriuretic effect of d-PAM. |
TextSentencer_T14 |
1152-1197 |
Sentence |
denotes |
One patient (1) did not take d-PAM regularly. |
TextSentencer_T15 |
1198-1277 |
Sentence |
denotes |
In this study PF was performed with the use of haemonetics V-50 and filter 704. |
TextSentencer_T16 |
1278-1361 |
Sentence |
denotes |
During the treatment with PF, 2000 ml of plasma was always exchanged, i.e. removed. |
TextSentencer_T17 |
1362-1497 |
Sentence |
denotes |
During the treatment with PF the patients were hospitalized at the Department of Neurology and Psychiatry of Children and Young People. |
TextSentencer_T18 |
1498-1522 |
Sentence |
denotes |
CASE REPORT AND RESULTS: |
TextSentencer_T19 |
1523-1534 |
Sentence |
denotes |
Patient No. |
TextSentencer_T20 |
1535-1537 |
Sentence |
denotes |
1. |
TextSentencer_T21 |
1538-1597 |
Sentence |
denotes |
A 24-year-old man, born in 1965, came with a coarse tremor. |
TextSentencer_T22 |
1598-1643 |
Sentence |
denotes |
He has been diagnosed as WD at the age of 18. |
TextSentencer_T23 |
1644-1717 |
Sentence |
denotes |
Kayser-Fleischer rings were found in the cornea by slit-lamp examination. |
TextSentencer_T24 |
1718-1792 |
Sentence |
denotes |
The disease began when he was 15 years old with polymorphous difficulties. |
TextSentencer_T25 |
1793-1827 |
Sentence |
denotes |
In time tremor became more severe. |
TextSentencer_T26 |
1828-1879 |
Sentence |
denotes |
It was apparent when the patient made any movement. |
TextSentencer_T27 |
1880-1954 |
Sentence |
denotes |
The first treatment with PF (1) lasted from February 13 to March 16, 1989. |
TextSentencer_T28 |
1955-2001 |
Sentence |
denotes |
The patient had 10 PF without any side effect. |
TextSentencer_T29 |
2002-2055 |
Sentence |
denotes |
During the treatment with PF the patient felt better. |
TextSentencer_T30 |
2056-2150 |
Sentence |
denotes |
After PF-tremor was reduced significantly, and subjective and objective condition ameliorated. |
TextSentencer_T31 |
2151-2257 |
Sentence |
denotes |
The patient (1) was readmitted to the hospital on June 24, 1991 for continuation of the treatment with PF. |
TextSentencer_T32 |
2258-2339 |
Sentence |
denotes |
Anamnestic data and neurological examination revealed progression of the disease. |
TextSentencer_T33 |
2340-2386 |
Sentence |
denotes |
His condition became worse, especially tremor. |
TextSentencer_T34 |
2387-2472 |
Sentence |
denotes |
He could not write a single letter (Figures 1-5) and walk without help of the others. |
TextSentencer_T35 |
2473-2548 |
Sentence |
denotes |
His tremor became the severest when he made any kind of voluntary movement. |
TextSentencer_T36 |
2549-2633 |
Sentence |
denotes |
The second treatment with PF started on June 25, 1991 and finished on July 16, 1991. |
TextSentencer_T37 |
2634-2666 |
Sentence |
denotes |
He received 9 PF in this series. |
TextSentencer_T38 |
2667-2706 |
Sentence |
denotes |
The treatment was without side effects. |
TextSentencer_T39 |
2707-2747 |
Sentence |
denotes |
Tremor was reduced approximately by 15%. |
TextSentencer_T40 |
2748-2827 |
Sentence |
denotes |
Plasma copper examined before and after 9 PF showed different values (Table 2). |
TextSentencer_T41 |
2828-2919 |
Sentence |
denotes |
This difference (2.79 mumol/l; 23.70%) in plasma copper level was removed from circulation. |
TextSentencer_T42 |
2920-2931 |
Sentence |
denotes |
Patient No. |
TextSentencer_T43 |
2932-2934 |
Sentence |
denotes |
2. |
TextSentencer_T44 |
2935-3019 |
Sentence |
denotes |
A 23-year-old man, born in 1966, came to the hospital with acute exacerbation of WD. |
TextSentencer_T45 |
3020-3068 |
Sentence |
denotes |
At the age of 16 latent psychosis was diagnosed. |
TextSentencer_T46 |
3069-3157 |
Sentence |
denotes |
One year later diagnosis of WD was established in the hospital when he was 17 years old. |
TextSentencer_T47 |
3158-3231 |
Sentence |
denotes |
Kayser-Fleischer rings were found in the cornea by slit-lamp examination. |
TextSentencer_T48 |
3232-3415 |
Sentence |
denotes |
The treatment with d-PAM and other drugs (BAL, symptomatic therapies, sedatives, antidepressants, etc.) has been accompanied with good and long-term remissions and short exacerbation. |
TextSentencer_T49 |
3416-3492 |
Sentence |
denotes |
A few years later exacerbation became longer and longer and worse and worse. |
TextSentencer_T50 |
3493-3571 |
Sentence |
denotes |
He was admitted to the hospital on November 28, 1989 with acute relapse of WD. |
TextSentencer_T51 |
3572-3627 |
Sentence |
denotes |
His condition was very difficult, completely bedridden. |
TextSentencer_T52 |
3628-3710 |
Sentence |
denotes |
The treatment with PF started on December 26, 1989 and lasted to January 25, 1990. |
TextSentencer_T53 |
3711-3751 |
Sentence |
denotes |
The treatment with PF was without d-PAM. |
TextSentencer_T54 |
3752-3792 |
Sentence |
denotes |
He was only given symptomatic therapies. |
TextSentencer_T55 |
3793-3945 |
Sentence |
denotes |
After a few PF he demonstrated side effects with nausea, sometimes vomiting, face sweating, pulse rate of about 120/min while blood pressure was normal. |
TextSentencer_T56 |
3946-4034 |
Sentence |
denotes |
Therefore he was given human albumin in the next day, and no side effects were observed. |
TextSentencer_T57 |
4035-4162 |
Sentence |
denotes |
The removal of little plasma copper from blood circulation correlated well with a small improvement in clinical symtpomatology. |
TextSentencer_T58 |
4163-4215 |
Sentence |
denotes |
The rigidity was reduced and voluntary movements bec |
T1 |
0-109 |
Sentence |
denotes |
[Treatment of chronic Wilson's disease in 2 patients using plasmapheresis--clinico-biochemical observations]. |
T2 |
110-214 |
Sentence |
denotes |
Lecenje dva hronicna bolesnika od Vilsonove bolesti pomoću plazmafereze--klinicko-biohemijska zapazanja. |
T3 |
215-228 |
Sentence |
denotes |
INTRODUCTION: |
T4 |
229-359 |
Sentence |
denotes |
The introduction of penicillamine in the treatment of Wilson's disease (hepatolenticular degeneration) was a historical event [1]. |
T5 |
360-460 |
Sentence |
denotes |
D-pericillamine (d-PAM) showed some potential side effects such as myasthenia, kidney toxicity, etc. |
T6 |
461-563 |
Sentence |
denotes |
In previous decade the treatment of Wilson's disease (WD) with zinc sulphate started successfully [4]. |
T7 |
564-724 |
Sentence |
denotes |
Danks [7] described the use of exchanged transfusions, peritoneal dialysis and plasmapheresis in the treatment of young patients with WD in acute liver failure. |
T8 |
725-767 |
Sentence |
denotes |
These patients had acute copper poisoning. |
T9 |
768-810 |
Sentence |
denotes |
The results of this study were beneficial. |
T10 |
811-832 |
Sentence |
denotes |
MATERIAL AND METHODS: |
T11 |
833-948 |
Sentence |
denotes |
Therapeutic plasmapheresis (PF) has been used in many diseases in which immunological mechanisms are proved [8, 9]. |
T12 |
949-1043 |
Sentence |
denotes |
We started with using PF in the treatment of two young chronic patients with Wilson's disease. |
T13 |
1044-1151 |
Sentence |
denotes |
The clinical picture of patients became worse, probably due to the decrease in cupriuretic effect of d-PAM. |
T14 |
1152-1197 |
Sentence |
denotes |
One patient (1) did not take d-PAM regularly. |
T15 |
1198-1277 |
Sentence |
denotes |
In this study PF was performed with the use of haemonetics V-50 and filter 704. |
T16 |
1278-1361 |
Sentence |
denotes |
During the treatment with PF, 2000 ml of plasma was always exchanged, i.e. removed. |
T17 |
1362-1497 |
Sentence |
denotes |
During the treatment with PF the patients were hospitalized at the Department of Neurology and Psychiatry of Children and Young People. |
T18 |
1498-1522 |
Sentence |
denotes |
CASE REPORT AND RESULTS: |
T19 |
1523-1534 |
Sentence |
denotes |
Patient No. |
T20 |
1535-1537 |
Sentence |
denotes |
1. |
T21 |
1538-1597 |
Sentence |
denotes |
A 24-year-old man, born in 1965, came with a coarse tremor. |
T22 |
1598-1643 |
Sentence |
denotes |
He has been diagnosed as WD at the age of 18. |
T23 |
1644-1717 |
Sentence |
denotes |
Kayser-Fleischer rings were found in the cornea by slit-lamp examination. |
T24 |
1718-1792 |
Sentence |
denotes |
The disease began when he was 15 years old with polymorphous difficulties. |
T25 |
1793-1827 |
Sentence |
denotes |
In time tremor became more severe. |
T26 |
1828-1879 |
Sentence |
denotes |
It was apparent when the patient made any movement. |
T27 |
1880-1954 |
Sentence |
denotes |
The first treatment with PF (1) lasted from February 13 to March 16, 1989. |
T28 |
1955-2001 |
Sentence |
denotes |
The patient had 10 PF without any side effect. |
T29 |
2002-2055 |
Sentence |
denotes |
During the treatment with PF the patient felt better. |
T30 |
2056-2150 |
Sentence |
denotes |
After PF-tremor was reduced significantly, and subjective and objective condition ameliorated. |
T31 |
2151-2257 |
Sentence |
denotes |
The patient (1) was readmitted to the hospital on June 24, 1991 for continuation of the treatment with PF. |
T32 |
2258-2339 |
Sentence |
denotes |
Anamnestic data and neurological examination revealed progression of the disease. |
T33 |
2340-2386 |
Sentence |
denotes |
His condition became worse, especially tremor. |
T34 |
2387-2472 |
Sentence |
denotes |
He could not write a single letter (Figures 1-5) and walk without help of the others. |
T35 |
2473-2548 |
Sentence |
denotes |
His tremor became the severest when he made any kind of voluntary movement. |
T36 |
2549-2633 |
Sentence |
denotes |
The second treatment with PF started on June 25, 1991 and finished on July 16, 1991. |
T37 |
2634-2666 |
Sentence |
denotes |
He received 9 PF in this series. |
T38 |
2667-2706 |
Sentence |
denotes |
The treatment was without side effects. |
T39 |
2707-2747 |
Sentence |
denotes |
Tremor was reduced approximately by 15%. |
T40 |
2748-2827 |
Sentence |
denotes |
Plasma copper examined before and after 9 PF showed different values (Table 2). |
T41 |
2828-2919 |
Sentence |
denotes |
This difference (2.79 mumol/l; 23.70%) in plasma copper level was removed from circulation. |
T42 |
2920-2931 |
Sentence |
denotes |
Patient No. |
T43 |
2932-2934 |
Sentence |
denotes |
2. |
T44 |
2935-3019 |
Sentence |
denotes |
A 23-year-old man, born in 1966, came to the hospital with acute exacerbation of WD. |
T45 |
3020-3068 |
Sentence |
denotes |
At the age of 16 latent psychosis was diagnosed. |
T46 |
3069-3157 |
Sentence |
denotes |
One year later diagnosis of WD was established in the hospital when he was 17 years old. |
T47 |
3158-3231 |
Sentence |
denotes |
Kayser-Fleischer rings were found in the cornea by slit-lamp examination. |
T48 |
3232-3415 |
Sentence |
denotes |
The treatment with d-PAM and other drugs (BAL, symptomatic therapies, sedatives, antidepressants, etc.) has been accompanied with good and long-term remissions and short exacerbation. |
T49 |
3416-3492 |
Sentence |
denotes |
A few years later exacerbation became longer and longer and worse and worse. |
T50 |
3493-3571 |
Sentence |
denotes |
He was admitted to the hospital on November 28, 1989 with acute relapse of WD. |
T51 |
3572-3627 |
Sentence |
denotes |
His condition was very difficult, completely bedridden. |
T52 |
3628-3710 |
Sentence |
denotes |
The treatment with PF started on December 26, 1989 and lasted to January 25, 1990. |
T53 |
3711-3751 |
Sentence |
denotes |
The treatment with PF was without d-PAM. |
T54 |
3752-3792 |
Sentence |
denotes |
He was only given symptomatic therapies. |
T55 |
3793-3945 |
Sentence |
denotes |
After a few PF he demonstrated side effects with nausea, sometimes vomiting, face sweating, pulse rate of about 120/min while blood pressure was normal. |
T56 |
3946-4034 |
Sentence |
denotes |
Therefore he was given human albumin in the next day, and no side effects were observed. |
T57 |
4035-4162 |
Sentence |
denotes |
The removal of little plasma copper from blood circulation correlated well with a small improvement in clinical symtpomatology. |
T58 |
4163-4215 |
Sentence |
denotes |
The rigidity was reduced and voluntary movements bec |