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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 34-46 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T2 275-282 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T3 472-483 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T4 531-536 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T5 550-565 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T6 603-610 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T7 622-627 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T8 687-699 Body_part denotes gangliosides http://purl.org/sig/ont/fma/fma82816
T9 966-974 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T10 1045-1056 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816
T11 1108-1113 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T12 1129-1137 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T13 1156-1163 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T14 1192-1200 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T15 1307-1318 Body_part denotes ganglioside http://purl.org/sig/ont/fma/fma82816

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1216-1219 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 105-113 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 130-140 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T3 141-160 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T4 188-196 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 223-232 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 451-454 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T8 741-744 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T10 785-788 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T12 792-800 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 1011-1014 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T15 1227-1230 Disease denotes NTD http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075
T17 1242-1250 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 1337-1345 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 168-169 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 200-201 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T3 261-266 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T4 341-342 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 465-466 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 514-519 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T7 550-556 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T8 557-565 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T9 806-807 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 870-871 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 951-952 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1099-1104 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 34-46 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T2 275-282 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 472-483 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T4 531-536 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T5 603-610 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T6 622-627 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T7 652-670 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T8 687-699 Chemical denotes gangliosides http://purl.obolibrary.org/obo/CHEBI_28892
T9 708-720 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T10 1024-1031 Chemical denotes epitope http://purl.obolibrary.org/obo/CHEBI_53000
T11 1045-1056 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892
T12 1108-1113 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T13 1156-1163 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14 1307-1318 Chemical denotes ganglioside http://purl.obolibrary.org/obo/CHEBI_28892

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 11-22 Species denotes coronavirus Tax:11118
4 34-46 Chemical denotes gangliosides MESH:D005732
5 105-113 Disease denotes COVID-19 MESH:C000657245
25 115-123 Disease denotes Covid-19 MESH:C000657245
26 141-160 Disease denotes respiratory disease MESH:D012140
27 170-181 Species denotes coronavirus Tax:11118
28 188-198 Species denotes SARS-CoV-2 Tax:2697049
29 223-232 Disease denotes infection MESH:D007239
30 472-483 Chemical denotes ganglioside MESH:D005732
31 531-536 Chemical denotes lipid MESH:D008055
32 622-627 Chemical denotes lipid MESH:D008055
33 652-670 Chemical denotes hydroxychloroquine MESH:D006886
34 687-699 Chemical denotes gangliosides MESH:D005732
35 708-720 Chemical denotes azithromycin MESH:D017963
36 792-802 Species denotes SARS-CoV-2 Tax:2697049
37 929-937 Disease denotes Covid-19 MESH:C000657245
38 938-946 Species denotes patients Tax:9606
39 1045-1056 Chemical denotes ganglioside MESH:D005732
40 1108-1113 Chemical denotes lipid MESH:D008055
41 1242-1252 Species denotes SARS-CoV-2 Tax:2697049
42 1307-1318 Chemical denotes ganglioside MESH:D005732
43 1337-1347 Species denotes SARS-CoV-2 Tax:2697049

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-114 Sentence denotes Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19.
T2 115-199 Sentence denotes Covid-19 is an infectious respiratory disease due to a coronavirus named SARS-CoV-2.
T3 200-314 Sentence denotes A critical step of the infection cycle is the binding of the virus spike S protein to the cellular ACE-2 receptor.
T4 315-600 Sentence denotes This interaction involves a receptor binding domain (RBD) located at the center of the S trimer, whereas the lateral N-terminal domain (NTD) displays a flat ganglioside binding site that enables the virus to bind to lipid rafts of the plasma membrane, where the ACE-2 receptor resides.
T5 601-745 Sentence denotes S protein binding to lipid rafts can be blocked by hydroxychloroquine, which binds to gangliosides, and by azithromycin, which binds to the NTD.
T6 746-1015 Sentence denotes Based on these data, we identified the NTD of SARS-CoV-2 as a promising target for both therapeutic and vaccine strategies, a notion later supported by the discovery, in convalescent Covid-19 patients, of a neutralizing antibody (4A8) that selectively binds to the NTD.
T7 1016-1164 Sentence denotes The 4A8 epitope overlaps the ganglioside binding domain, denying any access of the virus to lipid rafts when the antibody is bound to the S protein.
T8 1165-1268 Sentence denotes Thus, our data explain why antibody binding to the tip of the NTD results in SARS-CoV-2 neutralization.
T9 1269-1480 Sentence denotes The high level of conservation of the ganglioside binding domain of SARS-CoV-2 (100% identity in 584 of 600 isolates analyzed worldwide) offers unique opportunities for innovative vaccine/therapeutic strategies.