PubMed:31213813 / 194-543 JSONTXT

{"project":"GoldHamster","denotations":[{"id":"T22","span":{"begin":37,"end":43},"obj":"CHEBI:52214"},{"id":"T23","span":{"begin":37,"end":43},"obj":"GO:0005488"},{"id":"T24","span":{"begin":101,"end":106},"obj":"D006801"},{"id":"T25","span":{"begin":101,"end":141},"obj":"C508053"},{"id":"T26","span":{"begin":101,"end":141},"obj":"C508053"},{"id":"T27","span":{"begin":107,"end":123},"obj":"UBERON:0000021"},{"id":"T31","span":{"begin":107,"end":130},"obj":"GO:0005154"},{"id":"T32","span":{"begin":107,"end":139},"obj":"Q01279"},{"id":"T33","span":{"begin":107,"end":139},"obj":"P0CY46"},{"id":"T34","span":{"begin":107,"end":139},"obj":"P55245"},{"id":"T35","span":{"begin":107,"end":139},"obj":"P00533"},{"id":"T36","span":{"begin":107,"end":139},"obj":"P04412"},{"id":"T38","span":{"begin":107,"end":139},"obj":"P13387"},{"id":"T39","span":{"begin":107,"end":139},"obj":"PR:000006933"},{"id":"T45","span":{"begin":143,"end":146},"obj":"CVCL_1K15"},{"id":"T46","span":{"begin":143,"end":147},"obj":"PR:P04626"},{"id":"T47","span":{"begin":143,"end":147},"obj":"PR:000002082"},{"id":"T48","span":{"begin":143,"end":147},"obj":"PR:Q03557"},{"id":"T49","span":{"begin":143,"end":147},"obj":"PR:P34708"},{"id":"T50","span":{"begin":143,"end":147},"obj":"PR:Q5AK64"},{"id":"T51","span":{"begin":224,"end":237},"obj":"SO:0000199"},{"id":"T52","span":{"begin":241,"end":244},"obj":"CVCL_1K15"},{"id":"T53","span":{"begin":241,"end":245},"obj":"PR:P04626"},{"id":"T54","span":{"begin":241,"end":245},"obj":"PR:000002082"},{"id":"T55","span":{"begin":241,"end":245},"obj":"PR:Q03557"},{"id":"T56","span":{"begin":241,"end":245},"obj":"PR:P34708"},{"id":"T57","span":{"begin":241,"end":245},"obj":"PR:Q5AK64"},{"id":"T58","span":{"begin":294,"end":297},"obj":"CVCL_1K15"},{"id":"T59","span":{"begin":294,"end":298},"obj":"PR:P04626"},{"id":"T60","span":{"begin":294,"end":298},"obj":"PR:000002082"},{"id":"T61","span":{"begin":294,"end":298},"obj":"PR:Q03557"},{"id":"T62","span":{"begin":294,"end":298},"obj":"PR:P34708"},{"id":"T63","span":{"begin":294,"end":298},"obj":"PR:Q5AK64"},{"id":"T64","span":{"begin":308,"end":326},"obj":"GO:0008283"},{"id":"T65","span":{"begin":313,"end":326},"obj":"UBERON:2000098"},{"id":"T66","span":{"begin":339,"end":348},"obj":"GO:0097194"},{"id":"T67","span":{"begin":339,"end":348},"obj":"GO:0006915"}],"text":"Purpose: As well as functioning as a ligand that is selectively internalized by cells overexpressing human epidermal growth factor receptor-2 (HER2), HApt can exert cytotoxic effects by inducing cross-linking and subsequent translocation of HER2 to cytoplasmic vesicles, such downregulation of HER2 inhibits cell proliferation and induces apoptosis."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":0,"end":349},"obj":"DRI_Outcome"}],"text":"Purpose: As well as functioning as a ligand that is selectively internalized by cells overexpressing human epidermal growth factor receptor-2 (HER2), HApt can exert cytotoxic effects by inducing cross-linking and subsequent translocation of HER2 to cytoplasmic vesicles, such downregulation of HER2 inhibits cell proliferation and induces apoptosis."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T4","span":{"begin":35,"end":36},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"}],"text":"Purpose: As well as functioning as a ligand that is selectively internalized by cells overexpressing human epidermal growth factor receptor-2 (HER2), HApt can exert cytotoxic effects by inducing cross-linking and subsequent translocation of HER2 to cytoplasmic vesicles, such downregulation of HER2 inhibits cell proliferation and induces apoptosis."}