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Precision Engineers: Bacteriophages Modulate the Gut Microbiome and Metabolome. The precise and rational manipulation of the gut microbiome may enable new therapies for gut health and disease. In this issue of Cell Host & Microbe, Hsu et al. (2019) reveal that bacteriophage predation reduces target bacteria and results in cascading interactions that alter non-target species and the gut metabolome.

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