PubMed:30630951 / 976-1227 JSONTXT

{"project":"PubMed_ArguminSci","denotations":[{"id":"T7","span":{"begin":0,"end":251},"obj":"DRI_Approach"}],"text":"We generated de novo SGs by expressing the fragile X protein (FMRP) and found that rather than directly engaging TDP-43 aggregates, SGs can sequester the proteostasis factor histone deacetylase 6 (HDAC6) and thereby impede TDP-43 clearance from cells."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T24","span":{"begin":0,"end":2},"obj":"CVCL_5M23|Cancer_cell_line|Mesocricetus auratus"},{"id":"T25","span":{"begin":21,"end":24},"obj":"CVCL_4007|Cancer_cell_line|Rattus norvegicus"},{"id":"T26","span":{"begin":117,"end":119},"obj":"CVCL_UU94|Spontaneously_immortalized_cell_line|Cricetulus griseus"},{"id":"T27","span":{"begin":132,"end":135},"obj":"CVCL_4007|Cancer_cell_line|Rattus norvegicus"},{"id":"T28","span":{"begin":227,"end":229},"obj":"CVCL_UU94|Spontaneously_immortalized_cell_line|Cricetulus griseus"}],"text":"We generated de novo SGs by expressing the fragile X protein (FMRP) and found that rather than directly engaging TDP-43 aggregates, SGs can sequester the proteostasis factor histone deacetylase 6 (HDAC6) and thereby impede TDP-43 clearance from cells."}

{"project":"GoldHamster","denotations":[{"id":"T323","span":{"begin":21,"end":24},"obj":"CVCL_4007"},{"id":"T324","span":{"begin":21,"end":24},"obj":"C537328"},{"id":"T325","span":{"begin":21,"end":24},"obj":"C536632"},{"id":"T326","span":{"begin":51,"end":60},"obj":"P0DOF1"},{"id":"T327","span":{"begin":51,"end":60},"obj":"P0DOF0"},{"id":"T328","span":{"begin":53,"end":60},"obj":"GO:0003675"},{"id":"T332","span":{"begin":53,"end":60},"obj":"SO:0000104"},{"id":"T329","span":{"begin":53,"end":60},"obj":"CHEBI:36080"},{"id":"T330","span":{"begin":53,"end":60},"obj":"CHEBI:11122"},{"id":"T333","span":{"begin":62,"end":66},"obj":"P35922"},{"id":"T334","span":{"begin":62,"end":66},"obj":"PR:000003389"},{"id":"T335","span":{"begin":62,"end":66},"obj":"Q6GLC9"},{"id":"T336","span":{"begin":62,"end":66},"obj":"Q80WE1"},{"id":"T337","span":{"begin":62,"end":66},"obj":"Q5R9B4"},{"id":"T338","span":{"begin":62,"end":66},"obj":"Q06787"},{"id":"T339","span":{"begin":113,"end":116},"obj":"CHEBI:61377"},{"id":"T340","span":{"begin":113,"end":116},"obj":"CHEBI:61417"},{"id":"T341","span":{"begin":113,"end":119},"obj":"PR:Q13148"},{"id":"T342","span":{"begin":113,"end":119},"obj":"PR:Q921F2"},{"id":"T343","span":{"begin":113,"end":119},"obj":"PR:000016057"},{"id":"T344","span":{"begin":113,"end":119},"obj":"PR:Q5ZLN5"},{"id":"T345","span":{"begin":113,"end":119},"obj":"Q5R5W2"},{"id":"T346","span":{"begin":113,"end":119},"obj":"Q28F51"},{"id":"T347","span":{"begin":113,"end":119},"obj":"Q921F2"},{"id":"T348","span":{"begin":113,"end":119},"obj":"Q5ZLN5"},{"id":"T349","span":{"begin":113,"end":119},"obj":"Q13148"},{"id":"T350","span":{"begin":132,"end":135},"obj":"CVCL_4007"},{"id":"T351","span":{"begin":132,"end":135},"obj":"C537328"},{"id":"T352","span":{"begin":132,"end":135},"obj":"C536632"},{"id":"T357","span":{"begin":174,"end":195},"obj":"PR:000008485"},{"id":"T358","span":{"begin":174,"end":195},"obj":"Q9FML2"},{"id":"T359","span":{"begin":174,"end":195},"obj":"Q9Z2V5"},{"id":"T361","span":{"begin":174,"end":195},"obj":"Q9UBN7"},{"id":"T362","span":{"begin":174,"end":195},"obj":"Q20296"},{"id":"T360","span":{"begin":174,"end":195},"obj":"D000073864"},{"id":"T364","span":{"begin":197,"end":202},"obj":"PR:Q9UBN7"},{"id":"T365","span":{"begin":197,"end":202},"obj":"PR:Q9Z2V5"},{"id":"T366","span":{"begin":197,"end":202},"obj":"PR:000008485"},{"id":"T367","span":{"begin":223,"end":226},"obj":"CHEBI:61377"},{"id":"T368","span":{"begin":223,"end":226},"obj":"CHEBI:61417"},{"id":"T369","span":{"begin":223,"end":229},"obj":"PR:Q13148"},{"id":"T370","span":{"begin":223,"end":229},"obj":"PR:Q921F2"},{"id":"T371","span":{"begin":223,"end":229},"obj":"PR:000016057"},{"id":"T372","span":{"begin":223,"end":229},"obj":"PR:Q5ZLN5"},{"id":"T373","span":{"begin":223,"end":229},"obj":"Q5R5W2"},{"id":"T374","span":{"begin":223,"end":229},"obj":"Q28F51"},{"id":"T375","span":{"begin":223,"end":229},"obj":"Q921F2"},{"id":"T376","span":{"begin":223,"end":229},"obj":"Q5ZLN5"},{"id":"T377","span":{"begin":223,"end":229},"obj":"Q13148"}],"text":"We generated de novo SGs by expressing the fragile X protein (FMRP) and found that rather than directly engaging TDP-43 aggregates, SGs can sequester the proteostasis factor histone deacetylase 6 (HDAC6) and thereby impede TDP-43 clearance from cells."}

{"project":"sentences","denotations":[{"id":"T7","span":{"begin":0,"end":251},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We generated de novo SGs by expressing the fragile X protein (FMRP) and found that rather than directly engaging TDP-43 aggregates, SGs can sequester the proteostasis factor histone deacetylase 6 (HDAC6) and thereby impede TDP-43 clearance from cells."}