PubMed:28343984
Annnotations
GoldHamster
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-8 | GO:0051337 | denotes | Amitosis |
| T4 | 12-21 | SO:0001254 | denotes | Polyploid |
| T5 | 12-27 | D011123 | denotes | Polyploid Cells |
| T6 | 12-27 | D011123 | denotes | Polyploid Cells |
| T7 | 69-79 | 2294143 | denotes | Drosophila |
| T8 | 69-79 | 504603 | denotes | Drosophila |
| T9 | 69-79 | 2294139 | denotes | Drosophila |
| T10 | 69-79 | 2294145 | denotes | Drosophila |
| T11 | 69-79 | 2294141 | denotes | Drosophila |
| T12 | 69-79 | 2294142 | denotes | Drosophila |
| T13 | 69-79 | 2294144 | denotes | Drosophila |
| T14 | 69-79 | 2294140 | denotes | Drosophila |
| T15 | 69-79 | D004330 | denotes | Drosophila |
| T16 | 69-79 | 2080301 | denotes | Drosophila |
| T17 | 80-89 | UBERON:0000160 | denotes | Intestine |
| T18 | 143-152 | CL:0000034 | denotes | stem cell |
| T19 | 196-205 | CL:0000034 | denotes | stem cell |
| T20 | 234-246 | D009369 | denotes | malignancies |
| T21 | 234-246 | D009369 | denotes | malignancies |
| T22 | 251-256 | GO:0007568 | denotes | aging |
| T23 | 318-327 | CL:0000034 | denotes | stem cell |
| T24 | 495-499 | PR:P0A6B7 | denotes | ISCs |
| T26 | 495-499 | PR:A5I4Z9 | denotes | ISCs |
| T25 | 495-499 | GO:1990221 | denotes | ISCs |
| T27 | 495-499 | GO:0031071 | denotes | ISCs |
| T28 | 508-518 | 2294143 | denotes | Drosophila |
| T29 | 508-518 | 504603 | denotes | Drosophila |
| T30 | 508-518 | 2294139 | denotes | Drosophila |
| T31 | 508-518 | 2294145 | denotes | Drosophila |
| T32 | 508-518 | 2294141 | denotes | Drosophila |
| T33 | 508-518 | 2294142 | denotes | Drosophila |
| T34 | 508-518 | 2294144 | denotes | Drosophila |
| T35 | 508-518 | 2294140 | denotes | Drosophila |
| T36 | 508-518 | D004330 | denotes | Drosophila |
| T37 | 508-518 | 2080301 | denotes | Drosophila |
| T38 | 519-525 | UBERON:0001045 | denotes | midgut |
| T40 | 542-549 | CVCL_E018 | denotes | spindle |
| T39 | 542-549 | GO:0005819 | denotes | spindle |
| T41 | 569-578 | MOP:0000569 | denotes | reduction |
| T42 | 595-605 | CL:0000584 | denotes | enterocyte |
| T43 | 641-649 | GO:0051337 | denotes | amitosis |
| T44 | 651-659 | GO:0051337 | denotes | Amitosis |
| T45 | 702-706 | PR:P0A6B7 | denotes | ISCs |
| T47 | 702-706 | PR:A5I4Z9 | denotes | ISCs |
| T46 | 702-706 | GO:1990221 | denotes | ISCs |
| T48 | 702-706 | GO:0031071 | denotes | ISCs |
| T49 | 720-726 | UBERON:0000479 | denotes | tissue |
| T50 | 741-746 | GO:0007568 | denotes | aging |
| T51 | 747-752 | D004175 | denotes | flies |
| T52 | 836-846 | SO:0000857 | denotes | homologous |
| T53 | 836-869 | GO:0045143 | denotes | homologous chromosome segregation |
| T54 | 847-857 | GO:0005694 | denotes | chromosome |
| T55 | 847-857 | SO:0000340 | denotes | chromosome |
| T57 | 884-893 | MOP:0000569 | denotes | reduction |
| T58 | 935-957 | SO:0001786 | denotes | loss of heterozygosity |
| T59 | 991-999 | GO:0051337 | denotes | amitosis |
| T60 | 1044-1053 | CL:0000034 | denotes | stem cell |
| T61 | 1054-1065 | GO:0042592 | denotes | homeostasis |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 91-257 | DRI_Background | denotes | Organ fitness depends on appropriate maintenance of stem cell populations, and aberrations in functional stem cell numbers are associated with malignancies and aging. |
| T2 | 258-428 | DRI_Challenge | denotes | Symmetrical division is the best characterized mechanism of stem cell replacement, but other mechanisms could also be deployed, particularly in situations of high stress. |
| T3 | 429-650 | DRI_Outcome | denotes | Here, we show that after severe depletion, intestinal stem cells (ISCs) in the Drosophila midgut are replaced by spindle-independent ploidy reduction of cells in the enterocyte lineage through a process known as amitosis. |
| T4 | 651-800 | DRI_Challenge | denotes | Amitosis is also induced by the functional loss of ISCs coupled with tissue demand and in aging flies, underscoring the generality of this mechanism. |
| T5 | 801-958 | DRI_Outcome | denotes | However, we also found that random homologous chromosome segregation during ploidy reduction can expose deleterious mutations through loss of heterozygosity. |
| T6 | 959-1131 | DRI_Outcome | denotes | Together, our results highlight amitosis as an unappreciated mechanism for restoring stem cell homeostasis, but one with some associated risk in animals carrying mutations. |
Goldhamster2_Cellosaurus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 435-437 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T2 | 542-549 | CVCL_E018|Induced_pluripotent_stem_cell|Homo sapiens | denotes | spindle |
| T3 | 622-623 | CVCL_6479|Finite_cell_line|Mus musculus | denotes | a |
| T4 | 810-812 | CVCL_5M23|Cancer_cell_line|Mesocricetus auratus | denotes | we |
| T5 | 1003-1005 | CVCL_8754|Cancer_cell_line|Homo sapiens | denotes | an |
| T6 | 1003-1005 | CVCL_H241|Cancer_cell_line|Homo sapiens | denotes | an |
| T7 | 1071-1074 | CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis | denotes | one |