PubMed:27543364 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/27543364","sourcedb":"PubMed","sourceid":"27543364","text":"Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study.\nBACKGROUND: Ultraviolet radiation (UVR) by sunlight results in an increasing number of skin conditions. Earlier studies have suggested a protective effect of topical treatment with the pineal hormone melatonin. However, this protective effect has never been evaluated in natural sunlight, and the optimal dosing has not been clarified.\nOBJECTIVE: The aim of this study was to investigate the sun protective effect of topical treatment with three different doses of melatonin (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight.\nMETHOD: The study was a randomized, placebo-controlled, double-blind study in healthy volunteers. Twenty-three healthy volunteers, 8 male and 15 female, were enrolled. The protective effect of three different doses of melatonin cream (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight was tested. All participants had their backs exposed to sun from 1:22 PM to 2:02 PM local time and UV-index was 9. Primary outcome was reduction in erythema evaluated by chromatography after sun exposure, when treated with topical melatonin cream (0.5%, 2.5%, 12.5%) versus placebo and no treatment. The erythema reaction was evaluated with chromatography and visual scoring at baseline, one, four, eight and 24h after exposure.\nRESULTS: Significant difference in erythema formation was found between areas treated with melatonin cream 12.5% and areas receiving placebo or no treatment (repeated measures ANOVA p=0.001). No differences were found between placebo and the 0.5% and 2.5% concentrations.\nCONCLUSION: Application of melatonin cream 12.5% protects against natural sunlight induced erythema.","tracks":[{"project":"Zierdiyeerkenaili_800","denotations":[{"id":"T1","span":{"begin":616,"end":624},"obj":"DP"},{"id":"T2","span":{"begin":916,"end":924},"obj":"DP"},{"id":"T3","span":{"begin":1101,"end":1109},"obj":"DP"},{"id":"T4","span":{"begin":1257,"end":1265},"obj":"DP"},{"id":"T5","span":{"begin":1417,"end":1425},"obj":"DP"},{"id":"T6","span":{"begin":1745,"end":1753},"obj":"DP"},{"id":"T7","span":{"begin":578,"end":587},"obj":"CI"},{"id":"T8","span":{"begin":48,"end":57},"obj":"CI"},{"id":"T9","span":{"begin":313,"end":322},"obj":"CI"},{"id":"T10","span":{"begin":872,"end":881},"obj":"CI"},{"id":"T11","span":{"begin":1184,"end":1193},"obj":"CI"},{"id":"T12","span":{"begin":1473,"end":1482},"obj":"CI"},{"id":"T13","span":{"begin":1681,"end":1690},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T2","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T3","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T4","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T5","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T6","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T7","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T8","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T9","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T10","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T11","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T12","pred":"source","obj":"Zierdiyeerkenaili_800"},{"subj":"T13","pred":"source","obj":"Zierdiyeerkenaili_800"}]},{"project":"yangbin123xm_800_3","denotations":[{"id":"T1","span":{"begin":48,"end":57},"obj":"CI"},{"id":"T2","span":{"begin":313,"end":322},"obj":"CI"},{"id":"T3","span":{"begin":578,"end":587},"obj":"CI"},{"id":"T4","span":{"begin":872,"end":881},"obj":"CI"},{"id":"T5","span":{"begin":1184,"end":1193},"obj":"CI"},{"id":"T6","span":{"begin":1473,"end":1482},"obj":"CI"},{"id":"T7","span":{"begin":1681,"end":1690},"obj":"CI"},{"id":"T8","span":{"begin":1227,"end":1234},"obj":"CI"},{"id":"T11","span":{"begin":1515,"end":1522},"obj":"CI"},{"id":"T12","span":{"begin":1608,"end":1615},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T2","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T3","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T4","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T5","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T6","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T7","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T8","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T11","pred":"source","obj":"yangbin123xm_800_3"},{"subj":"T12","pred":"source","obj":"yangbin123xm_800_3"}]},{"project":"chenxin_473849_800_3","denotations":[{"id":"T1","span":{"begin":578,"end":587},"obj":"CI"},{"id":"T2","span":{"begin":48,"end":57},"obj":"CI"},{"id":"T3","span":{"begin":313,"end":322},"obj":"CI"},{"id":"T4","span":{"begin":872,"end":881},"obj":"CI"},{"id":"T5","span":{"begin":1184,"end":1193},"obj":"CI"},{"id":"T6","span":{"begin":1473,"end":1482},"obj":"CI"},{"id":"T7","span":{"begin":1681,"end":1690},"obj":"CI"},{"id":"T8","span":{"begin":1227,"end":1234},"obj":"CI"},{"id":"T11","span":{"begin":1515,"end":1522},"obj":"CI"},{"id":"T12","span":{"begin":1608,"end":1615},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T2","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T3","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T4","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T5","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T6","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T7","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T8","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T11","pred":"source","obj":"chenxin_473849_800_3"},{"subj":"T12","pred":"source","obj":"chenxin_473849_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Zierdiyeerkenaili_800","color":"#b893ec","default":true},{"id":"yangbin123xm_800_3","color":"#93ec9e"},{"id":"chenxin_473849_800_3","color":"#ec93a1"}]}]}}