In vitro biomechanical modulation-retinal detachment in a box.
BACKGROUND: To illustrate the importance of biomechanical impact on tissue health within the central nervous system (CNS), we herein describe an in vitro model of rhegmatogenous retinal detachment (RRD) in which disruption and restoration of physical tissue support can be studied in isolation.
METHODS: Adult retinal porcine explants were kept in culture for 3 or 12 hours without any tissue support, sim