Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial.
BACKGROUND: The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown.
OBJECTIVE: To assess NBI for the detection of proximal colon serrated lesions.
DESIGN: Randomized, controlled trial.
SETTING: Two academic hospital outpatient units.
PATIENTS: Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations.
INTERVENTIONS: Randomization to colon inspection in NBI versus white-light colonoscopy.
MAIN OUTCOME MEASUREMENTS: The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon.
RESULTS: The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups.
LIMITATIONS: Lack of blinding, endoscopic estimation of polyp location.
CONCLUSION: NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (
CLINICAL TRIAL REGISTRATION NUMBER: NCT01572428.).