Challenges in the early detection and intervention of the psychosis-risk syndrome. The concept of a clinical high-risk state for psychosis has been used to describe individuals who have prodromal symptoms of psychosis and, thus, are at high-risk of developing psychosis. This high-risk concept promotes a more detailed developmental understanding of the evolution of psychosis and provides a theoretical basis for providing necessary mental health services to people at clinically high-risk of developing psychosis. Early detection and intervention can potentially change the course of psychotic conditions and, thus, prevent or minimize the associated disability. This is a relatively new area of interest, so more studies are needed to fully understand this high-risk condition.