Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-181 |
Sentence |
denotes |
Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT-II): an open-label, randomised controlled trial. |
TextSentencer_T2 |
182-193 |
Sentence |
denotes |
BACKGROUND: |
TextSentencer_T3 |
194-306 |
Sentence |
denotes |
There is little evidence to guide the management of women with hypertensive disorders in late preterm pregnancy. |
TextSentencer_T4 |
307-432 |
Sentence |
denotes |
We investigated the effect of immediate delivery versus expectant monitoring on maternal and neonatal outcomes in such women. |
TextSentencer_T5 |
433-441 |
Sentence |
denotes |
METHODS: |
TextSentencer_T6 |
442-570 |
Sentence |
denotes |
We did an open-label, randomised controlled trial, in seven academic hospitals and 44 non-academic hospitals in the Netherlands. |
TextSentencer_T7 |
571-869 |
Sentence |
denotes |
Women with non-severe hypertensive disorders of pregnancy between 34 and 37 weeks of gestation were randomly allocated to either induction of labour or caesarean section within 24 h (immediate delivery) or a strategy aimed at prolonging pregnancy until 37 weeks of gestation (expectant monitoring). |
TextSentencer_T8 |
870-1128 |
Sentence |
denotes |
The primary outcomes were a composite of adverse maternal outcomes (thromboembolic disease, pulmonary oedema, eclampsia, HELLP syndrome, placental abruption, or maternal death), and neonatal respiratory distress syndrome, both analysed by intention-to-treat. |
TextSentencer_T9 |
1129-1200 |
Sentence |
denotes |
This study is registered with the Netherlands Trial Register (NTR1792). |
TextSentencer_T10 |
1201-1210 |
Sentence |
denotes |
FINDINGS: |
TextSentencer_T11 |
1211-1401 |
Sentence |
denotes |
Between March 1, 2009, and Feb 21, 2013, 897 women were invited to participate, of whom 703 were enrolled and randomly assigned to immediate delivery (n=352) or expectant monitoring (n=351). |
TextSentencer_T12 |
1402-1627 |
Sentence |
denotes |
The composite adverse maternal outcome occurred in four (1·1%) of 352 women allocated to immediate delivery versus 11 (3·1%) of 351 women allocated to expectant monitoring (relative risk [RR] 0·36, 95% CI 0·12-1·11; p=0·069). |
TextSentencer_T13 |
1628-1835 |
Sentence |
denotes |
Respiratory distress syndrome was diagnosed in 20 (5·7%) of 352 neonates in the immediate delivery group versus six (1·7%) of 351 neonates in the expectant monitoring group (RR 3·3, 95% CI 1·4-8·2; p=0·005). |
TextSentencer_T14 |
1836-1877 |
Sentence |
denotes |
No maternal or perinatal deaths occurred. |
TextSentencer_T15 |
1878-1893 |
Sentence |
denotes |
INTERPRETATION: |
TextSentencer_T16 |
1894-2056 |
Sentence |
denotes |
For women with non-severe hypertensive disorders at 34-37 weeks of gestation, immediate delivery might reduce the already small risk of adverse maternal outcomes. |
TextSentencer_T17 |
2057-2306 |
Sentence |
denotes |
However, it significantly increases the risk of neonatal respiratory distress syndrome, therefore, routine immediate delivery does not seem justified and a strategy of expectant monitoring until the clinical situation deteriorates can be considered. |
TextSentencer_T18 |
2307-2315 |
Sentence |
denotes |
FUNDING: |
TextSentencer_T19 |
2316-2322 |
Sentence |
denotes |
ZonMw. |
T1 |
0-181 |
Sentence |
denotes |
Immediate delivery versus expectant monitoring for hypertensive disorders of pregnancy between 34 and 37 weeks of gestation (HYPITAT-II): an open-label, randomised controlled trial. |
T2 |
182-193 |
Sentence |
denotes |
BACKGROUND: |
T3 |
194-306 |
Sentence |
denotes |
There is little evidence to guide the management of women with hypertensive disorders in late preterm pregnancy. |
T4 |
307-432 |
Sentence |
denotes |
We investigated the effect of immediate delivery versus expectant monitoring on maternal and neonatal outcomes in such women. |
T5 |
433-441 |
Sentence |
denotes |
METHODS: |
T6 |
442-570 |
Sentence |
denotes |
We did an open-label, randomised controlled trial, in seven academic hospitals and 44 non-academic hospitals in the Netherlands. |
T7 |
571-869 |
Sentence |
denotes |
Women with non-severe hypertensive disorders of pregnancy between 34 and 37 weeks of gestation were randomly allocated to either induction of labour or caesarean section within 24 h (immediate delivery) or a strategy aimed at prolonging pregnancy until 37 weeks of gestation (expectant monitoring). |
T8 |
870-1128 |
Sentence |
denotes |
The primary outcomes were a composite of adverse maternal outcomes (thromboembolic disease, pulmonary oedema, eclampsia, HELLP syndrome, placental abruption, or maternal death), and neonatal respiratory distress syndrome, both analysed by intention-to-treat. |
T9 |
1129-1200 |
Sentence |
denotes |
This study is registered with the Netherlands Trial Register (NTR1792). |
T10 |
1201-1210 |
Sentence |
denotes |
FINDINGS: |
T11 |
1211-1401 |
Sentence |
denotes |
Between March 1, 2009, and Feb 21, 2013, 897 women were invited to participate, of whom 703 were enrolled and randomly assigned to immediate delivery (n=352) or expectant monitoring (n=351). |
T12 |
1402-1627 |
Sentence |
denotes |
The composite adverse maternal outcome occurred in four (1·1%) of 352 women allocated to immediate delivery versus 11 (3·1%) of 351 women allocated to expectant monitoring (relative risk [RR] 0·36, 95% CI 0·12-1·11; p=0·069). |
T13 |
1628-1835 |
Sentence |
denotes |
Respiratory distress syndrome was diagnosed in 20 (5·7%) of 352 neonates in the immediate delivery group versus six (1·7%) of 351 neonates in the expectant monitoring group (RR 3·3, 95% CI 1·4-8·2; p=0·005). |
T14 |
1836-1877 |
Sentence |
denotes |
No maternal or perinatal deaths occurred. |
T15 |
1878-1893 |
Sentence |
denotes |
INTERPRETATION: |
T16 |
1894-2056 |
Sentence |
denotes |
For women with non-severe hypertensive disorders at 34-37 weeks of gestation, immediate delivery might reduce the already small risk of adverse maternal outcomes. |
T17 |
2057-2306 |
Sentence |
denotes |
However, it significantly increases the risk of neonatal respiratory distress syndrome, therefore, routine immediate delivery does not seem justified and a strategy of expectant monitoring until the clinical situation deteriorates can be considered. |
T18 |
2307-2315 |
Sentence |
denotes |
FUNDING: |
T19 |
2316-2322 |
Sentence |
denotes |
ZonMw. |