PubMed:25760041 / 866-1207 JSONTXT

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{"project":"UseCases_ArguminSci_Discourse","denotations":[{"id":"T5","span":{"begin":0,"end":341},"obj":"DRI_Outcome"}],"text":"Here we show that reduction of SUPT4H expression in brains of zQ175 mice by intracerebroventricular bolus injection of antisense 2'-O-methoxyethyl oligonucleotides (ASOs) directed against Supt4h, or in R6/2 mice by deletion of one copy of the Supt4h gene, results in a decrease in mRNA and protein encoded specifically by mutant Htt alleles."}