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PubMed:25595946 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 28-44 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T2 28-44 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T3 28-44 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T4 69-85 https://glytoucan.org/Structures/Glycans/G20420WT denotes Lactosylceramide
T5 69-85 https://glytoucan.org/Structures/Glycans/G74621DY denotes Lactosylceramide
T6 69-85 https://glytoucan.org/Structures/Glycans/G84224TW denotes Lactosylceramide

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 28-44 Glycan_Motif denotes lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T4 69-85 Glycan_Motif denotes Lactosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G74621DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20420WT
T7 87-93 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T8 320-326 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T9 414-420 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T10 422-428 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T11 526-532 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T12 563-569 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T13 600-606 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T14 664-670 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T15 801-807 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T16 985-991 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T17 1370-1376 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T18 1393-1399 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T19 1531-1537 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW
T20 1559-1565 Glycan_Motif denotes LacCer https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G84224TW

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-68 Sentence denotes Properties and functions of lactosylceramide from mouse neutrophils.
TextSentencer_T2 69-246 Sentence denotes Lactosylceramide (LacCer), which is essential for many cellular processes, is highly expressed on the plasma membranes of human neutrophils and mediates innate immune functions.
TextSentencer_T3 247-348 Sentence denotes Less is known, however, about the properties and biological functions of LacCer in mouse neutrophils.
TextSentencer_T4 349-421 Sentence denotes This study therefore analyzed the properties of mouse neutrophil LacCer.
TextSentencer_T5 422-638 Sentence denotes LacCer was observed on the surface of these cells, with flow cytometry indicating that mouse neutrophil LacCer could be detected by the anti-LacCer mAb T5A7, but not by the anti-LacCer antibodies Huly-m13 and MEM-74.
TextSentencer_T6 639-891 Sentence denotes The molecular species of LacCer were nearly identical in mouse and human neutrophils, including C24:0 and C24:1 fatty acid chain-containing species, although the LacCer content in plasma membranes was ∼ 20-fold lower in mouse than in human neutrophils.
TextSentencer_T7 892-1047 Sentence denotes Surface plasmon resonance analysis revealed that T5A7 bound to a lipid monolayer composed of LacCer, DOPC, cholesterol and sphingomyelin (molar ratio 0.1 :
TextSentencer_T8 1048-1052 Sentence denotes 10 :
TextSentencer_T9 1053-1057 Sentence denotes 10 :
TextSentencer_T10 1058-1087 Sentence denotes 1), whereas Huly-m13 did not.
TextSentencer_T11 1088-1224 Sentence denotes T5A7 induced neutrophil migration, which was abolished by inhibitors of Src-family kinases, PI-3 kinases, and trimeric G (o/i) proteins.
TextSentencer_T12 1225-1299 Sentence denotes T5A7 also inhibited phagocytosis of non-opsonized zymosans by neutrophils.
TextSentencer_T13 1300-1613 Sentence denotes Taken together, these findings suggest that in mouse neutrophils, (i) LacCer is expressed as LacCer-enriched microdomains in cell surface plasma membranes, (ii) these microdomains are recognized by T5A7 but not by other known anti-LacCer antibodies and (iii) LacCer is involved in cell migration and phagocytosis.
T1 0-68 Sentence denotes Properties and functions of lactosylceramide from mouse neutrophils.
T2 69-246 Sentence denotes Lactosylceramide (LacCer), which is essential for many cellular processes, is highly expressed on the plasma membranes of human neutrophils and mediates innate immune functions.
T3 247-348 Sentence denotes Less is known, however, about the properties and biological functions of LacCer in mouse neutrophils.
T4 349-421 Sentence denotes This study therefore analyzed the properties of mouse neutrophil LacCer.
T5 422-638 Sentence denotes LacCer was observed on the surface of these cells, with flow cytometry indicating that mouse neutrophil LacCer could be detected by the anti-LacCer mAb T5A7, but not by the anti-LacCer antibodies Huly-m13 and MEM-74.
T6 639-891 Sentence denotes The molecular species of LacCer were nearly identical in mouse and human neutrophils, including C24:0 and C24:1 fatty acid chain-containing species, although the LacCer content in plasma membranes was ∼ 20-fold lower in mouse than in human neutrophils.
T7 892-1047 Sentence denotes Surface plasmon resonance analysis revealed that T5A7 bound to a lipid monolayer composed of LacCer, DOPC, cholesterol and sphingomyelin (molar ratio 0.1 :
T8 1048-1052 Sentence denotes 10 :
T9 1053-1057 Sentence denotes 10 :
T10 1058-1087 Sentence denotes 1), whereas Huly-m13 did not.
T11 1088-1224 Sentence denotes T5A7 induced neutrophil migration, which was abolished by inhibitors of Src-family kinases, PI-3 kinases, and trimeric G (o/i) proteins.
T12 1225-1299 Sentence denotes T5A7 also inhibited phagocytosis of non-opsonized zymosans by neutrophils.
T13 1300-1613 Sentence denotes Taken together, these findings suggest that in mouse neutrophils, (i) LacCer is expressed as LacCer-enriched microdomains in cell surface plasma membranes, (ii) these microdomains are recognized by T5A7 but not by other known anti-LacCer antibodies and (iii) LacCer is involved in cell migration and phagocytosis.
T1 0-68 Sentence denotes Properties and functions of lactosylceramide from mouse neutrophils.
T2 69-246 Sentence denotes Lactosylceramide (LacCer), which is essential for many cellular processes, is highly expressed on the plasma membranes of human neutrophils and mediates innate immune functions.
T3 247-348 Sentence denotes Less is known, however, about the properties and biological functions of LacCer in mouse neutrophils.
T4 349-421 Sentence denotes This study therefore analyzed the properties of mouse neutrophil LacCer.
T5 422-638 Sentence denotes LacCer was observed on the surface of these cells, with flow cytometry indicating that mouse neutrophil LacCer could be detected by the anti-LacCer mAb T5A7, but not by the anti-LacCer antibodies Huly-m13 and MEM-74.
T6 639-891 Sentence denotes The molecular species of LacCer were nearly identical in mouse and human neutrophils, including C24:0 and C24:1 fatty acid chain-containing species, although the LacCer content in plasma membranes was ∼ 20-fold lower in mouse than in human neutrophils.
T7 892-1047 Sentence denotes Surface plasmon resonance analysis revealed that T5A7 bound to a lipid monolayer composed of LacCer, DOPC, cholesterol and sphingomyelin (molar ratio 0.1 :
T8 1048-1052 Sentence denotes 10 :
T9 1053-1057 Sentence denotes 10 :
T10 1058-1087 Sentence denotes 1), whereas Huly-m13 did not.
T11 1088-1224 Sentence denotes T5A7 induced neutrophil migration, which was abolished by inhibitors of Src-family kinases, PI-3 kinases, and trimeric G (o/i) proteins.
T12 1225-1299 Sentence denotes T5A7 also inhibited phagocytosis of non-opsonized zymosans by neutrophils.
T13 1300-1613 Sentence denotes Taken together, these findings suggest that in mouse neutrophils, (i) LacCer is expressed as LacCer-enriched microdomains in cell surface plasma membranes, (ii) these microdomains are recognized by T5A7 but not by other known anti-LacCer antibodies and (iii) LacCer is involved in cell migration and phagocytosis.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 28-44 https://glytoucan.org/Structures/Glycans/G20420WT denotes lactosylceramide
T2 28-44 https://glytoucan.org/Structures/Glycans/G74621DY denotes lactosylceramide
T3 28-44 https://glytoucan.org/Structures/Glycans/G84224TW denotes lactosylceramide
T4 69-85 https://glytoucan.org/Structures/Glycans/G20420WT denotes Lactosylceramide
T5 69-85 https://glytoucan.org/Structures/Glycans/G74621DY denotes Lactosylceramide
T6 69-85 https://glytoucan.org/Structures/Glycans/G84224TW denotes Lactosylceramide

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 28-44 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
T2 69-85 http://www.glycoepitope.jp/epitopes/EP0078 denotes Lactosylceramide
T3 87-93 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T4 320-326 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T5 414-420 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T6 422-428 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T7 526-532 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T8 563-569 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T9 574-578 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
T10 600-606 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T11 618-626 http://www.glycoepitope.jp/epitopes/AN0624 denotes Huly-m13
T12 664-670 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T13 801-807 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T14 941-945 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
T15 985-991 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T16 1070-1078 http://www.glycoepitope.jp/epitopes/AN0624 denotes Huly-m13
T17 1088-1092 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
T18 1225-1229 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
T19 1370-1376 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T20 1393-1399 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T21 1498-1502 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
T22 1531-1537 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer
T23 1559-1565 http://www.glycoepitope.jp/epitopes/EP0078 denotes LacCer

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 28-44 FMAID:82821 denotes lactosylceramide
_T2 28-44 FMAID:196817 denotes lactosylceramide
_T3 56-67 FMAID:167158 denotes neutrophils
_T4 56-67 FMAID:62860 denotes neutrophils
_T5 56-67 FMAID:167159 denotes neutrophils
_T6 69-85 FMAID:82821 denotes Lactosylceramide
_T7 69-85 FMAID:196817 denotes Lactosylceramide
_T8 171-177 FMAID:162307 denotes plasma
_T9 171-187 FMAID:164993 denotes plasma membranes
_T10 171-187 FMAID:66843 denotes plasma membranes
_T11 171-187 FMAID:210691 denotes plasma membranes
_T12 171-187 FMAID:63841 denotes plasma membranes
_T13 171-187 FMAID:162306 denotes plasma membranes
_T14 171-190 FMAID:166047 denotes plasma membranes of
_T15 171-190 FMAID:67865 denotes plasma membranes of
_T16 171-190 FMAID:166539 denotes plasma membranes of
_T17 171-208 FMAID:255987 denotes plasma membranes of human neutrophils
_T18 171-208 FMAID:255988 denotes plasma membranes of human neutrophils
_T19 171-208 FMAID:255984 denotes plasma membranes of human neutrophils
_T20 171-208 FMAID:255983 denotes plasma membranes of human neutrophils
_T21 178-187 FMAID:7145 denotes membranes
_T22 178-187 FMAID:167608 denotes membranes
_T23 178-187 FMAID:93573 denotes membranes
_T24 178-187 FMAID:30322 denotes membranes
_T25 197-208 FMAID:167159 denotes neutrophils
_T26 197-208 FMAID:167158 denotes neutrophils
_T27 197-208 FMAID:62860 denotes neutrophils
_T28 336-347 FMAID:62860 denotes neutrophils
_T29 336-347 FMAID:167158 denotes neutrophils
_T30 336-347 FMAID:167159 denotes neutrophils
_T31 403-413 FMAID:62860 denotes neutrophil
_T32 403-413 FMAID:167158 denotes neutrophil
_T33 403-413 FMAID:167159 denotes neutrophil
_T34 449-456 FMAID:146300 denotes surface
_T35 449-456 FMAID:50594 denotes surface
_T36 449-465 FMAID:118168 denotes surface of these
_T37 449-465 FMAID:25456 denotes surface of these
_T38 449-471 FMAID:165570 denotes surface of these cells
_T39 449-471 FMAID:67653 denotes surface of these cells
_T40 466-471 FMAID:68646 denotes cells
_T41 466-471 FMAID:169002 denotes cells
_T42 515-525 FMAID:167158 denotes neutrophil
_T43 515-525 FMAID:167159 denotes neutrophil
_T44 515-525 FMAID:62860 denotes neutrophil
_T45 607-617 FMAID:167180 denotes antibodies
_T46 712-723 FMAID:167159 denotes neutrophils
_T47 712-723 FMAID:62860 denotes neutrophils
_T48 712-723 FMAID:167158 denotes neutrophils
_T49 751-761 FMAID:82738 denotes fatty acid
_T50 751-761 FMAID:196726 denotes fatty acid
_T51 819-825 FMAID:162307 denotes plasma
_T52 826-835 FMAID:30322 denotes membranes
_T53 826-835 FMAID:93573 denotes membranes
_T54 826-835 FMAID:7145 denotes membranes
_T55 826-835 FMAID:167608 denotes membranes
_T56 826-839 FMAID:76711 denotes membranes was
_T57 826-839 FMAID:183865 denotes membranes was
_T58 879-890 FMAID:167158 denotes neutrophils
_T59 879-890 FMAID:167159 denotes neutrophils
_T60 879-890 FMAID:62860 denotes neutrophils
_T61 892-899 FMAID:50594 denotes Surface
_T62 892-899 FMAID:146300 denotes Surface
_T63 957-962 FMAID:165448 denotes lipid
_T64 957-962 FMAID:67264 denotes lipid
_T65 1101-1111 FMAID:62860 denotes neutrophil
_T66 1101-1111 FMAID:167158 denotes neutrophil
_T67 1101-1111 FMAID:167159 denotes neutrophil
_T68 1180-1182 FMAID:214745 denotes PI
_T69 1215-1223 FMAID:165447 denotes proteins
_T70 1215-1223 FMAID:67257 denotes proteins
_T71 1287-1298 FMAID:167159 denotes neutrophils
_T72 1287-1298 FMAID:62860 denotes neutrophils
_T73 1287-1298 FMAID:167158 denotes neutrophils
_T74 1353-1364 FMAID:167158 denotes neutrophils
_T75 1353-1364 FMAID:167159 denotes neutrophils
_T76 1353-1364 FMAID:62860 denotes neutrophils
_T77 1430-1437 FMAID:50594 denotes surface
_T78 1430-1437 FMAID:146300 denotes surface
_T79 1430-1454 FMAID:164995 denotes surface plasma membranes
_T80 1438-1444 FMAID:162307 denotes plasma
_T81 1438-1454 FMAID:63841 denotes plasma membranes
_T82 1438-1454 FMAID:210691 denotes plasma membranes
_T83 1438-1454 FMAID:164993 denotes plasma membranes
_T84 1438-1454 FMAID:162306 denotes plasma membranes
_T85 1438-1454 FMAID:166047 denotes plasma membranes
_T86 1438-1454 FMAID:66843 denotes plasma membranes
_T87 1445-1454 FMAID:30322 denotes membranes
_T88 1445-1454 FMAID:167608 denotes membranes
_T89 1445-1454 FMAID:7145 denotes membranes
_T90 1445-1454 FMAID:93573 denotes membranes
_T91 1538-1548 FMAID:167180 denotes antibodies
_T92 1578-1585 FMAID:84785 denotes in cell
_T93 1578-1585 FMAID:199054 denotes in cell

uniprot-human

Id Subject Object Predicate Lexical cue
T1 1180-1182 http://www.uniprot.org/uniprot/Q86U18 denotes PI
T2 1180-1182 http://www.uniprot.org/uniprot/P01298 denotes PI
T3 1180-1184 http://www.uniprot.org/uniprot/P19957 denotes PI-3
T4 1457-1459 http://www.uniprot.org/uniprot/Q8SNA0 denotes ii

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1160-1163 http://www.uniprot.org/uniprot/P05480 denotes Src
T2 1457-1459 http://www.uniprot.org/uniprot/P04441 denotes ii

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 119-123 http://purl.bioontology.org/ontology/NCBITAXON/9973 denotes many
T2 296-316 http://purl.bioontology.org/ontology/STY/T039 denotes biological functions
T3 466-471 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 1261-1264 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non
T5 1322-1330 http://purl.bioontology.org/ontology/STY/T033 denotes findings

GO-BP

Id Subject Object Predicate Lexical cue
T1 124-132 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T2 124-142 http://purl.obolibrary.org/obo/GO_0009987 denotes cellular processes
T3 222-235 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T4 1101-1121 http://purl.obolibrary.org/obo/GO_1990266 denotes neutrophil migration
T5 1171-1184 http://purl.obolibrary.org/obo/GO_0014065 denotes kinases, PI-3
T6 1235-1257 http://purl.obolibrary.org/obo/GO_0050765 denotes inhibited phagocytosis
T7 1245-1257 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T8 1600-1612 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T9 1265-1274 http://purl.obolibrary.org/obo/GO_0008228 denotes opsonized
T10 1581-1595 http://purl.obolibrary.org/obo/GO_0016477 denotes cell migration

GO-MF

Id Subject Object Predicate Lexical cue
T1 607-617 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2 1538-1548 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies

GO-CC

Id Subject Object Predicate Lexical cue
T1 171-187 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membranes
T2 819-835 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membranes
T3 1438-1454 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membranes
T4 178-187 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T5 826-835 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T6 1445-1454 http://purl.obolibrary.org/obo/GO_0016020 denotes membranes
T7 449-471 http://purl.obolibrary.org/obo/GO_0009986 denotes surface of these cells
T8 1425-1437 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface
T9 466-471 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10 1425-1429 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T11 1581-1585 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12 1438-1459 http://purl.obolibrary.org/obo/GO_0030096 denotes plasma membranes, (ii

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1261-1264 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 1261-1264 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 1261-1264 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 1261-1264 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 1261-1264 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 1261-1264 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 1261-1264 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 1261-1264 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 1261-1264 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 1261-1264 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 1261-1264 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 1160-1163 https://acgg.asia/db/lfdb/LfDB0103 denotes Src

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 28-44 http://www.glycoepitope.jp/epitopes/EP0078 denotes lactosylceramide
PD-GlycoEpitope-B_T2 69-85 http://www.glycoepitope.jp/epitopes/EP0078 denotes Lactosylceramide
PD-GlycoEpitope-B_T3 574-578 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
PD-GlycoEpitope-B_T4 941-945 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
PD-GlycoEpitope-B_T5 1088-1092 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
PD-GlycoEpitope-B_T6 1225-1229 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
PD-GlycoEpitope-B_T7 1498-1502 http://www.glycoepitope.jp/epitopes/AN0483 denotes T5A7
PD-GlycoEpitope-B_T8 618-626 http://www.glycoepitope.jp/epitopes/AN0624 denotes Huly-m13
PD-GlycoEpitope-B_T9 1070-1078 http://www.glycoepitope.jp/epitopes/AN0624 denotes Huly-m13
PD-GlycoEpitope-B_T10 1053-1059 http://www.glycoepitope.jp/epitopes/AN0577 denotes 10 : 1

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 28-44 Glycan denotes lactosylceramide
T2 69-85 Glycan denotes Lactosylceramide
T3 87-93 Glycan denotes LacCer
T4 320-326 Glycan denotes LacCer
T5 414-420 Glycan denotes LacCer
T6 422-428 Glycan denotes LacCer
T7 526-532 Glycan denotes LacCer
T8 563-569 Glycan denotes LacCer
T9 600-606 Glycan denotes LacCer
T10 664-670 Glycan denotes LacCer
T11 801-807 Glycan denotes LacCer
T12 985-991 Glycan denotes LacCer
T13 1370-1376 Glycan denotes LacCer
T14 1393-1399 Glycan denotes LacCer
T15 1531-1537 Glycan denotes LacCer
T16 1559-1565 Glycan denotes LacCer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1101-1121 Disease denotes neutrophil migration http://purl.obolibrary.org/obo/MONDO_0008091

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 28-44 Glycan denotes lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T2 69-85 Glycan denotes Lactosylceramide https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T3 87-93 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T4 320-326 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T5 414-420 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T6 422-428 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T7 526-532 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T8 563-569 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T9 600-606 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T10 664-670 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T11 801-807 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T12 985-991 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T13 1370-1376 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T14 1393-1399 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T15 1531-1537 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW
T16 1559-1565 Glycan denotes LacCer https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 50-55 OrganismTaxon denotes mouse 10088|10090
T3 191-196 OrganismTaxon denotes human 9606
T4 330-335 OrganismTaxon denotes mouse 10088|10090
T6 397-402 OrganismTaxon denotes mouse 10088|10090
T8 509-514 OrganismTaxon denotes mouse 10088|10090
T10 696-701 OrganismTaxon denotes mouse 10088|10090
T12 706-711 OrganismTaxon denotes human 9606
T13 859-864 OrganismTaxon denotes mouse 10088|10090
T15 873-878 OrganismTaxon denotes human 9606
T16 1347-1352 OrganismTaxon denotes mouse 10088|10090

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 56-67 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T2 197-208 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T3 336-347 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T4 403-413 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T5 515-525 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T6 712-723 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T7 879-890 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T8 1101-1111 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T9 1287-1298 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T10 1353-1364 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-68 Sentence denotes Properties and functions of lactosylceramide from mouse neutrophils.
T2 69-246 Sentence denotes Lactosylceramide (LacCer), which is essential for many cellular processes, is highly expressed on the plasma membranes of human neutrophils and mediates innate immune functions.
T3 247-348 Sentence denotes Less is known, however, about the properties and biological functions of LacCer in mouse neutrophils.
T4 349-421 Sentence denotes This study therefore analyzed the properties of mouse neutrophil LacCer.
T5 422-638 Sentence denotes LacCer was observed on the surface of these cells, with flow cytometry indicating that mouse neutrophil LacCer could be detected by the anti-LacCer mAb T5A7, but not by the anti-LacCer antibodies Huly-m13 and MEM-74.
T6 639-891 Sentence denotes The molecular species of LacCer were nearly identical in mouse and human neutrophils, including C24:0 and C24:1 fatty acid chain-containing species, although the LacCer content in plasma membranes was ∼ 20-fold lower in mouse than in human neutrophils.
T7 892-1047 Sentence denotes Surface plasmon resonance analysis revealed that T5A7 bound to a lipid monolayer composed of LacCer, DOPC, cholesterol and sphingomyelin (molar ratio 0.1 :
T8 1048-1052 Sentence denotes 10 :
T9 1053-1057 Sentence denotes 10 :
T10 1058-1087 Sentence denotes 1), whereas Huly-m13 did not.
T11 1088-1224 Sentence denotes T5A7 induced neutrophil migration, which was abolished by inhibitors of Src-family kinases, PI-3 kinases, and trimeric G (o/i) proteins.
T12 1225-1299 Sentence denotes T5A7 also inhibited phagocytosis of non-opsonized zymosans by neutrophils.
T13 1300-1613 Sentence denotes Taken together, these findings suggest that in mouse neutrophils, (i) LacCer is expressed as LacCer-enriched microdomains in cell surface plasma membranes, (ii) these microdomains are recognized by T5A7 but not by other known anti-LacCer antibodies and (iii) LacCer is involved in cell migration and phagocytosis.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 28-44 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T2 69-85 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T3 87-93 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T4 320-326 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T5 414-420 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T6 422-428 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T7 526-532 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T8 563-569 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T9 574-578 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T10 600-606 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T11 618-626 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Huly-m13 http://www.glycoepitope.jp/epitopes/AN0624
T12 664-670 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T13 801-807 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T14 941-945 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T15 985-991 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T16 1070-1078 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Huly-m13 http://www.glycoepitope.jp/epitopes/AN0624
T17 1088-1092 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T18 1225-1229 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T19 1370-1376 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T20 1393-1399 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T21 1498-1502 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T22 1531-1537 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T23 1559-1565 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 56-67 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T2 124-142 Body_part denotes cellular processes http://purl.obolibrary.org/obo/GO_0042995
T3 171-187 Body_part denotes plasma membranes http://purl.obolibrary.org/obo/GO_0005886
T4 197-208 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T5 336-347 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T6 403-413 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T7 515-525 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T8 712-723 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T9 819-835 Body_part denotes plasma membranes http://purl.obolibrary.org/obo/GO_0005886
T10 879-890 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T11 1030-1035 Body_part denotes molar http://purl.obolibrary.org/obo/UBERON_0003655
T12 1101-1111 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T13 1287-1298 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T14 1353-1364 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T15 1438-1454 Body_part denotes plasma membranes http://purl.obolibrary.org/obo/GO_0005886

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 56-67 Body_part denotes neutrophils FMA:62860
T2 171-187 Body_part denotes plasma membranes FMA:63841
T3 197-208 Body_part denotes neutrophils FMA:62860
T4 336-347 Body_part denotes neutrophils FMA:62860
T5 403-413 Body_part denotes neutrophil FMA:62860
T6 515-525 Body_part denotes neutrophil FMA:62860
T7 712-723 Body_part denotes neutrophils FMA:62860
T8 819-835 Body_part denotes plasma membranes FMA:63841
T9 879-890 Body_part denotes neutrophils FMA:62860
T10 1101-1111 Body_part denotes neutrophil FMA:62860
T11 1287-1298 Body_part denotes neutrophils FMA:62860
T12 1353-1364 Body_part denotes neutrophils FMA:62860
T13 1425-1437 Body_part denotes cell surface FMA:67653
T14 1438-1454 Body_part denotes plasma membranes FMA:63841

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 50-55 OrganismTaxon denotes mouse 10088|10090
T3 191-196 OrganismTaxon denotes human 9606
T4 330-335 OrganismTaxon denotes mouse 10088|10090
T6 397-402 OrganismTaxon denotes mouse 10088|10090
T8 509-514 OrganismTaxon denotes mouse 10088|10090
T10 696-701 OrganismTaxon denotes mouse 10088|10090
T12 706-711 OrganismTaxon denotes human 9606
T13 859-864 OrganismTaxon denotes mouse 10088|10090
T15 873-878 OrganismTaxon denotes human 9606
T16 1347-1352 OrganismTaxon denotes mouse 10088|10090

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 28-44 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T2 69-85 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lactosylceramide http://www.glycoepitope.jp/epitopes/EP0078
T3 87-93 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T4 320-326 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T5 414-420 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T6 422-428 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T7 526-532 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T8 563-569 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T9 574-578 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T10 600-606 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T11 618-626 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Huly-m13 http://www.glycoepitope.jp/epitopes/AN0624
T12 664-670 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T13 801-807 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T14 941-945 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T15 985-991 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T16 1070-1078 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Huly-m13 http://www.glycoepitope.jp/epitopes/AN0624
T17 1088-1092 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T18 1225-1229 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T19 1370-1376 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T20 1393-1399 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T21 1498-1502 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T5A7 http://www.glycoepitope.jp/epitopes/AN0483
T22 1531-1537 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078
T23 1559-1565 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes LacCer http://www.glycoepitope.jp/epitopes/EP0078

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 56-67 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T2 124-142 Body_part denotes cellular processes http://purl.obolibrary.org/obo/GO_0042995
T3 171-187 Body_part denotes plasma membranes http://purl.obolibrary.org/obo/GO_0005886
T4 197-208 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T5 336-347 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T6 403-413 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T7 515-525 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T8 712-723 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T9 819-835 Body_part denotes plasma membranes http://purl.obolibrary.org/obo/GO_0005886
T10 879-890 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T11 1030-1035 Body_part denotes molar http://purl.obolibrary.org/obo/UBERON_0003655
T12 1101-1111 Body_part denotes neutrophil http://purl.obolibrary.org/obo/CL_0000775
T13 1287-1298 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T14 1353-1364 Body_part denotes neutrophils http://purl.obolibrary.org/obo/CL_0000775
T15 1438-1454 Body_part denotes plasma membranes http://purl.obolibrary.org/obo/GO_0005886

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 56-67 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T2 197-208 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T3 336-347 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T4 403-413 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T5 515-525 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T6 712-723 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T7 879-890 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T8 1101-1111 Cell denotes neutrophil http://purl.obolibrary.org/obo/CL:0000775
T9 1287-1298 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775
T10 1353-1364 Cell denotes neutrophils http://purl.obolibrary.org/obo/CL:0000775