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PubMed:25353630 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 85-213 DRI_Outcome denotes The Toll-Like Receptor 2 (TLR2) plays an active and important role in Staphylococcus aureus-induced chronic ocular inflammation.
T2 214-363 DRI_Background denotes The aim of this study was to investigate the expression and function of TLR2 of corneal stromal cells in ex vivo rabbit model of S. aureus keratitis.
T3 364-521 DRI_Background denotes Corneal buttons with sclera rims placed in an ex vivo air-interface organ culture were assigned to two groups: corneas with epithelial and stromal abrasions.
T4 522-651 DRI_Approach denotes Each group was then divided into two sub-groups exposed to UV-killed S. aureus ATCC 6538P and S. aureus ATCC 29213, respectively.
T5 652-730 DRI_Background denotes TLR2 and IL-8 mRNA expressions were analyzed by quantitative real-time RT-PCR.
T6 796-938 DRI_Outcome denotes The results demonstrated that TLR2 and IL-8 mRNA were significantly expressed in the stromal cells of the groups exposed to S. aureus strains.
T7 939-1108 DRI_Outcome denotes Moreover, it has been demonstrated that, after corneal injury, keratocytes differentiated into myofibroblasts became able to express TLR2 only when exposed to S. aureus.
T8 1109-1260 DRI_Challenge denotes Identification of mechanisms regulation of corneal TLRs may lead to development of therapeutic interventions aimed at controlling corneal inflammation.
T9 1261-1401 DRI_Challenge denotes This ex vivo model can be used to clarify the molecular events of bacterial-corneal tissue interactions and their inflammatory consequences.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 0-4 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T2 5-15 CVCL_C410|Hybridoma|Mus musculus denotes activation
T3 111-115 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T4 123-125 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T5 123-125 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T6 126-132 CVCL_C410|Hybridoma|Mus musculus denotes active
T7 286-290 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T8 372-379 CVCL_D937|Induced_pluripotent_stem_cell|Homo sapiens denotes buttons
T9 407-409 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T10 407-409 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T11 652-656 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T12 718-722 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T13 731-735 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T14 826-830 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T15 952-955 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T16 952-955 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T17 1072-1076 CVCL_5600|Conditionally_immortalized_cell_line|Mus musculus denotes TLR2
T18 1165-1168 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-4 PR:Q9QUN7 denotes TLR2
T2 0-4 PR:O60603 denotes TLR2
T3 0-4 PR:000001153 denotes TLR2
T4 0-4 CVCL_5600 denotes TLR2
T6 44-65 D013211 denotes Staphylococcus aureus
T7 44-65 1280 denotes Staphylococcus aureus
T8 74-83 D007634 denotes keratitis
T9 74-83 D007634 denotes keratitis
T13 89-109 B2LT61 denotes Toll-Like Receptor 2
T14 89-109 Q0GC71 denotes Toll-Like Receptor 2
T16 89-109 Q95LA9 denotes Toll-Like Receptor 2
T17 89-109 B2LT65 denotes Toll-Like Receptor 2
T18 89-109 B3Y615 denotes Toll-Like Receptor 2
T19 89-109 Q9QUN7 denotes Toll-Like Receptor 2
T20 89-109 B3Y618 denotes Toll-Like Receptor 2
T21 89-109 B3Y613 denotes Toll-Like Receptor 2
T22 89-109 B5T267 denotes Toll-Like Receptor 2
T23 89-109 Q9R1F8 denotes Toll-Like Receptor 2
T24 89-109 Q689D1 denotes Toll-Like Receptor 2
T25 89-109 B2LT62 denotes Toll-Like Receptor 2
T26 89-109 Q2V897 denotes Toll-Like Receptor 2
T27 89-109 Q95M53 denotes Toll-Like Receptor 2
T28 89-109 Q6T752 denotes Toll-Like Receptor 2
T29 89-109 B3Y614 denotes Toll-Like Receptor 2
T30 89-109 Q2PZH4 denotes Toll-Like Receptor 2
T31 89-109 B2LT64 denotes Toll-Like Receptor 2
T32 89-109 O60603 denotes Toll-Like Receptor 2
T33 89-109 PR:000001153 denotes Toll-Like Receptor 2
T15 89-109 D051195 denotes Toll-Like Receptor 2
T34 111-115 PR:Q9QUN7 denotes TLR2
T35 111-115 PR:O60603 denotes TLR2
T36 111-115 PR:000001153 denotes TLR2
T37 111-115 CVCL_5600 denotes TLR2
T39 155-176 D013211 denotes Staphylococcus aureus
T40 155-176 1280 denotes Staphylococcus aureus
T41 200-212 GO:0006954 denotes inflammation
T42 200-212 D007249 denotes inflammation
T43 200-212 D007249 denotes inflammation
T44 286-290 PR:Q9QUN7 denotes TLR2
T45 286-290 PR:O60603 denotes TLR2
T46 286-290 PR:000001153 denotes TLR2
T47 286-290 CVCL_5600 denotes TLR2
T49 327-333 813859 denotes rabbit
T48 327-333 D011817 denotes rabbit
T50 327-333 9986 denotes rabbit
T51 353-362 D007634 denotes keratitis
T52 353-362 D007634 denotes keratitis
T55 385-391 UBERON:0001773 denotes sclera
T53 385-391 D015422 denotes sclera
T54 385-391 D015422 denotes sclera
T56 432-437 UBERON:0000062 denotes organ
T57 432-437 UBERON:0003103 denotes organ
T58 475-482 UBERON:0000964 denotes corneas
T59 559-562 PR:Q8RWZ1 denotes sub
T60 559-562 PR:Q9V877 denotes sub
T61 652-656 PR:Q9QUN7 denotes TLR2
T62 652-656 PR:O60603 denotes TLR2
T63 652-656 PR:000001153 denotes TLR2
T64 652-656 CVCL_5600 denotes TLR2
T65 661-665 P19874 denotes IL-8
T66 661-665 PR:000001395 denotes IL-8
T67 661-665 P10145 denotes IL-8
T68 661-665 Q102R3 denotes IL-8
T69 661-665 P67813 denotes IL-8
T70 661-665 P67814 denotes IL-8
T71 661-665 P08317 denotes IL-8
T72 661-665 P79255 denotes IL-8
T73 661-665 P49113 denotes IL-8
T74 661-665 P41324 denotes IL-8
T75 661-665 P26894 denotes IL-8
T77 661-665 PR:P10145 denotes IL-8
T78 661-665 P46653 denotes IL-8
T79 661-665 Q7YRB5 denotes IL-8
T80 661-665 P36925 denotes IL-8
T82 661-665 PR:P08317 denotes IL-8
T85 661-665 Q9XSX5 denotes IL-8
T86 661-665 O62812 denotes IL-8
T76 661-665 D016209 denotes IL-8
T81 661-665 D016209 denotes IL-8
T84 661-665 CHEBI:138181 denotes IL-8
T83 661-665 GO:0005153 denotes IL-8
T89 666-670 SO:0000234 denotes mRNA
T87 666-670 D012333 denotes mRNA
T88 666-670 CHEBI:33699 denotes mRNA
T90 726-729 Q41249 denotes PCR
T91 726-729 O66148 denotes PCR
T92 726-729 Q59987 denotes PCR
T93 726-729 Q01289 denotes PCR
T94 726-729 O80333 denotes PCR
T95 726-729 P15904 denotes PCR
T96 726-729 Q9SDT1 denotes PCR
T97 726-729 Q39617 denotes PCR
T98 731-735 PR:Q9QUN7 denotes TLR2
T99 731-735 PR:O60603 denotes TLR2
T100 731-735 PR:000001153 denotes TLR2
T101 731-735 CVCL_5600 denotes TLR2
T102 736-748 GO:0051179 denotes localization
T103 826-830 PR:Q9QUN7 denotes TLR2
T104 826-830 PR:O60603 denotes TLR2
T105 826-830 PR:000001153 denotes TLR2
T106 826-830 CVCL_5600 denotes TLR2
T107 835-839 P19874 denotes IL-8
T108 835-839 PR:000001395 denotes IL-8
T109 835-839 P10145 denotes IL-8
T110 835-839 Q102R3 denotes IL-8
T111 835-839 P67813 denotes IL-8
T112 835-839 P67814 denotes IL-8
T113 835-839 P08317 denotes IL-8
T114 835-839 P79255 denotes IL-8
T115 835-839 P49113 denotes IL-8
T116 835-839 P41324 denotes IL-8
T117 835-839 P26894 denotes IL-8
T119 835-839 PR:P10145 denotes IL-8
T120 835-839 P46653 denotes IL-8
T121 835-839 Q7YRB5 denotes IL-8
T122 835-839 P36925 denotes IL-8
T124 835-839 PR:P08317 denotes IL-8
T127 835-839 Q9XSX5 denotes IL-8
T128 835-839 O62812 denotes IL-8
T118 835-839 D016209 denotes IL-8
T123 835-839 D016209 denotes IL-8
T126 835-839 CHEBI:138181 denotes IL-8
T125 835-839 GO:0005153 denotes IL-8
T131 840-844 SO:0000234 denotes mRNA
T129 840-844 D012333 denotes mRNA
T130 840-844 CHEBI:33699 denotes mRNA
T132 930-937 D013180 denotes strains
T133 930-937 D013180 denotes strains
T134 986-1000 D065306 denotes corneal injury
T135 986-1000 D065306 denotes corneal injury
T136 1072-1076 PR:Q9QUN7 denotes TLR2
T137 1072-1076 PR:O60603 denotes TLR2
T138 1072-1076 PR:000001153 denotes TLR2
T139 1072-1076 CVCL_5600 denotes TLR2
T140 1138-1148 GO:0065007 denotes regulation
T141 1247-1259 GO:0006954 denotes inflammation
T142 1247-1259 D007249 denotes inflammation
T143 1247-1259 D007249 denotes inflammation
T144 1345-1351 UBERON:0000479 denotes tissue

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-84 Sentence denotes TLR2 activation in corneal stromal cells by Staphylococcus aureus-induced keratitis.
T2 85-213 Sentence denotes The Toll-Like Receptor 2 (TLR2) plays an active and important role in Staphylococcus aureus-induced chronic ocular inflammation.
T3 214-363 Sentence denotes The aim of this study was to investigate the expression and function of TLR2 of corneal stromal cells in ex vivo rabbit model of S. aureus keratitis.
T4 364-521 Sentence denotes Corneal buttons with sclera rims placed in an ex vivo air-interface organ culture were assigned to two groups: corneas with epithelial and stromal abrasions.
T5 522-651 Sentence denotes Each group was then divided into two sub-groups exposed to UV-killed S. aureus ATCC 6538P and S. aureus ATCC 29213, respectively.
T6 652-730 Sentence denotes TLR2 and IL-8 mRNA expressions were analyzed by quantitative real-time RT-PCR.
T7 731-795 Sentence denotes TLR2 localization was visualized by immunofluorescence analysis.
T8 796-938 Sentence denotes The results demonstrated that TLR2 and IL-8 mRNA were significantly expressed in the stromal cells of the groups exposed to S. aureus strains.
T9 939-1108 Sentence denotes Moreover, it has been demonstrated that, after corneal injury, keratocytes differentiated into myofibroblasts became able to express TLR2 only when exposed to S. aureus.
T10 1109-1260 Sentence denotes Identification of mechanisms regulation of corneal TLRs may lead to development of therapeutic interventions aimed at controlling corneal inflammation.
T11 1261-1401 Sentence denotes This ex vivo model can be used to clarify the molecular events of bacterial-corneal tissue interactions and their inflammatory consequences.
T1 0-84 Sentence denotes TLR2 activation in corneal stromal cells by Staphylococcus aureus-induced keratitis.
T2 85-213 Sentence denotes The Toll-Like Receptor 2 (TLR2) plays an active and important role in Staphylococcus aureus-induced chronic ocular inflammation.
T3 214-363 Sentence denotes The aim of this study was to investigate the expression and function of TLR2 of corneal stromal cells in ex vivo rabbit model of S. aureus keratitis.
T4 364-521 Sentence denotes Corneal buttons with sclera rims placed in an ex vivo air-interface organ culture were assigned to two groups: corneas with epithelial and stromal abrasions.
T5 522-651 Sentence denotes Each group was then divided into two sub-groups exposed to UV-killed S. aureus ATCC 6538P and S. aureus ATCC 29213, respectively.
T6 652-730 Sentence denotes TLR2 and IL-8 mRNA expressions were analyzed by quantitative real-time RT-PCR.
T7 731-795 Sentence denotes TLR2 localization was visualized by immunofluorescence analysis.
T8 796-938 Sentence denotes The results demonstrated that TLR2 and IL-8 mRNA were significantly expressed in the stromal cells of the groups exposed to S. aureus strains.
T9 939-1108 Sentence denotes Moreover, it has been demonstrated that, after corneal injury, keratocytes differentiated into myofibroblasts became able to express TLR2 only when exposed to S. aureus.
T10 1109-1260 Sentence denotes Identification of mechanisms regulation of corneal TLRs may lead to development of therapeutic interventions aimed at controlling corneal inflammation.
T11 1261-1401 Sentence denotes This ex vivo model can be used to clarify the molecular events of bacterial-corneal tissue interactions and their inflammatory consequences.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 193-212 HP_0100533 denotes ocular inflammation