> top > docs > PubMed:25286407 > annotations

PubMed:25286407 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 154-594 BACKGROUND denotes Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to investigate the deteriorative effects of lidocaine and bupivacaine on rabbit IVDs using an organotypic culture model and an in vivo long-term follow-up model.
T2 604-1121 METHODS denotes For the organotypic culture model, rabbit IVDs were harvested and cultured for 3 or 7 days after intradiscal injection of local anesthetics (1% lidocaine or 0.5% bupivacaine). Nucleus pulposus (NP) cell death was measured using confocal microscopy. Histological and TUNEL assays were performed. For in vivo study, each local anesthetic was injected into rabbit lumbar IVDs under a fluoroscope. Six or 12 months after the injection, each IVD was prepared for magnetic resonance imaging (MRI) and histological analysis.
T3 1131-1801 RESULTS denotes In the organotypic culture model, both anesthetic agents induced time-dependent NP cell death; when compared with injected saline solution, significant effects were detected within 7 days. Compared with the saline group, TUNEL-positive NP cells were significantly increased in the bupivacaine group. In the in vivo study, MRI analysis did not show any significant difference. Histological analysis revealed that IVD degeneration occurred to a significantly level in the saline- and local anesthetics-injected groups compared with the untreated control or puncture-only groups. However, there was no significant difference between the saline and anesthetic agents groups.
T4 1828-2206 CONCLUSIONS denotes In the in vivo model using healthy IVDs, there was no strong evidence to suggest that discoblock with local anesthetics has the potential of inducing IVD degeneration other than the initial mechanical damage of the pressurized injection. Further studies should be performed to investigate the deteriorative effects of the local injection of analgesic agents on degenerated IVDs.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 260-261 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 424-426 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T3 524-526 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T4 524-526 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T5 557-559 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T6 557-559 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T7 983-984 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T8 1002-1007 CVCL_S732|Cancer_cell_line|Homo sapiens denotes or 12
T9 1196-1200 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T10 1572-1573 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T11 1948-1951 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T12 1948-1951 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has

GoldHamster

Id Subject Object Predicate Lexical cue
T1 37-54 D000777 denotes anesthetic agents
T2 37-54 D000777 denotes anesthetic agents
T5 58-77 UBERON:0001066 denotes intervertebral disc
T6 58-90 D055959 denotes intervertebral disc degeneration
T7 58-90 D055959 denotes intervertebral disc degeneration
T10 109-113 original_id denotes term
T11 154-163 CHEBI:35480 denotes Analgesic
T12 233-246 D017116 denotes low back pain
T13 233-246 D017116 denotes low back pain
T16 242-246 PR:Q9W0Y6 denotes pain
T17 278-295 CHEBI:36333 denotes local anesthetics
T18 278-295 D000779 denotes local anesthetics
T19 278-295 D000779 denotes local anesthetics
T23 365-382 CHEBI:36333 denotes local anesthetics
T24 365-382 D000779 denotes local anesthetics
T25 365-382 D000779 denotes local anesthetics
T31 386-405 UBERON:0001066 denotes intervertebral disc
T29 386-405 C535531 denotes intervertebral disc
T30 386-405 C535531 denotes intervertebral disc
T32 407-410 Q9FS87 denotes IVD
T33 407-410 Q9SWG0 denotes IVD
T34 407-410 P12007 denotes IVD
T35 407-410 P26440 denotes IVD
T36 407-410 Q3SZI8 denotes IVD
T37 407-410 PR:P12007 denotes IVD
T38 407-410 P34275 denotes IVD
T39 407-410 Q9JHI5 denotes IVD
T40 407-410 PR:Q9SWG0 denotes IVD
T41 407-410 Q75IM9 denotes IVD
T42 407-410 PR:P26440 denotes IVD
T43 407-410 Q5RBD5 denotes IVD
T44 407-410 PR:000009166 denotes IVD
T45 407-410 PR:Q9JHI5 denotes IVD
T46 477-486 6387 denotes lidocaine
T47 477-486 D008012 denotes lidocaine
T48 477-486 CHEBI:6456 denotes lidocaine
T49 477-486 D008012 denotes lidocaine
T51 491-502 1815 denotes bupivacaine
T50 491-502 D002045 denotes bupivacaine
T52 491-502 CHEBI:3215 denotes bupivacaine
T53 491-502 CHEBI:60790 denotes bupivacaine
T54 491-502 CHEBI:6149 denotes bupivacaine
T55 491-502 D002045 denotes bupivacaine
T57 506-512 813859 denotes rabbit
T56 506-512 D011817 denotes rabbit
T58 506-512 9986 denotes rabbit
T59 573-577 original_id denotes term
T61 639-645 813859 denotes rabbit
T60 639-645 D011817 denotes rabbit
T62 639-645 9986 denotes rabbit
T65 726-743 CHEBI:36333 denotes local anesthetics
T66 726-743 D000779 denotes local anesthetics
T67 726-743 D000779 denotes local anesthetics
T71 748-757 6387 denotes lidocaine
T72 748-757 D008012 denotes lidocaine
T73 748-757 CHEBI:6456 denotes lidocaine
T74 748-757 D008012 denotes lidocaine
T76 766-777 1815 denotes bupivacaine
T75 766-777 D002045 denotes bupivacaine
T77 766-777 CHEBI:3215 denotes bupivacaine
T78 766-777 CHEBI:60790 denotes bupivacaine
T79 766-777 CHEBI:6149 denotes bupivacaine
T80 766-777 D002045 denotes bupivacaine
T83 780-787 GO:0005634 denotes Nucleus
T81 780-787 CHEBI:33252 denotes Nucleus
T84 780-796 UBERON:0002242 denotes Nucleus pulposus
T85 802-812 GO:0008219 denotes cell death
T87 958-964 813859 denotes rabbit
T86 958-964 D011817 denotes rabbit
T88 958-964 9986 denotes rabbit
T89 1041-1044 Q9FS87 denotes IVD
T90 1041-1044 Q9SWG0 denotes IVD
T91 1041-1044 P12007 denotes IVD
T92 1041-1044 P26440 denotes IVD
T93 1041-1044 Q3SZI8 denotes IVD
T94 1041-1044 PR:P12007 denotes IVD
T95 1041-1044 P34275 denotes IVD
T96 1041-1044 Q9JHI5 denotes IVD
T97 1041-1044 PR:Q9SWG0 denotes IVD
T98 1041-1044 Q75IM9 denotes IVD
T99 1041-1044 PR:P26440 denotes IVD
T100 1041-1044 Q5RBD5 denotes IVD
T101 1041-1044 PR:000009166 denotes IVD
T102 1041-1044 PR:Q9JHI5 denotes IVD
T103 1090-1093 PR:000010565 denotes MRI
T104 1090-1093 PR:Q6AYH4 denotes MRI
T105 1090-1093 PR:Q8BHZ5 denotes MRI
T106 1090-1093 PR:Q9BWK5 denotes MRI
T107 1170-1187 D000777 denotes anesthetic agents
T108 1170-1187 D000777 denotes anesthetic agents
T109 1214-1224 GO:0008219 denotes cell death
T110 1254-1269 D000077330 denotes saline solution
T113 1412-1423 1815 denotes bupivacaine
T112 1412-1423 D002045 denotes bupivacaine
T114 1412-1423 CHEBI:3215 denotes bupivacaine
T115 1412-1423 CHEBI:60790 denotes bupivacaine
T116 1412-1423 CHEBI:6149 denotes bupivacaine
T117 1412-1423 D002045 denotes bupivacaine
T118 1453-1456 PR:000010565 denotes MRI
T119 1453-1456 PR:Q6AYH4 denotes MRI
T120 1453-1456 PR:Q8BHZ5 denotes MRI
T121 1453-1456 PR:Q9BWK5 denotes MRI
T122 1543-1546 Q9FS87 denotes IVD
T123 1543-1546 Q9SWG0 denotes IVD
T124 1543-1546 P12007 denotes IVD
T125 1543-1546 P26440 denotes IVD
T126 1543-1546 Q3SZI8 denotes IVD
T127 1543-1546 PR:P12007 denotes IVD
T128 1543-1546 P34275 denotes IVD
T129 1543-1546 Q9JHI5 denotes IVD
T130 1543-1546 PR:Q9SWG0 denotes IVD
T131 1543-1546 Q75IM9 denotes IVD
T132 1543-1546 PR:P26440 denotes IVD
T133 1543-1546 Q5RBD5 denotes IVD
T134 1543-1546 PR:000009166 denotes IVD
T135 1543-1546 PR:Q9JHI5 denotes IVD
T137 1613-1630 CHEBI:36333 denotes local anesthetics
T138 1613-1630 D000779 denotes local anesthetics
T139 1613-1630 D000779 denotes local anesthetics
T143 1776-1793 D000777 denotes anesthetic agents
T144 1776-1793 D000777 denotes anesthetic agents
T145 1930-1947 CHEBI:36333 denotes local anesthetics
T146 1930-1947 D000779 denotes local anesthetics
T147 1930-1947 D000779 denotes local anesthetics
T151 1978-1981 Q9FS87 denotes IVD
T152 1978-1981 Q9SWG0 denotes IVD
T153 1978-1981 P12007 denotes IVD
T154 1978-1981 P26440 denotes IVD
T155 1978-1981 Q3SZI8 denotes IVD
T156 1978-1981 PR:P12007 denotes IVD
T157 1978-1981 P34275 denotes IVD
T158 1978-1981 Q9JHI5 denotes IVD
T159 1978-1981 PR:Q9SWG0 denotes IVD
T160 1978-1981 Q75IM9 denotes IVD
T161 1978-1981 PR:P26440 denotes IVD
T162 1978-1981 Q5RBD5 denotes IVD
T163 1978-1981 PR:000009166 denotes IVD
T164 1978-1981 PR:Q9JHI5 denotes IVD
T166 2169-2185 D000700 denotes analgesic agents
T167 2169-2185 D000700 denotes analgesic agents

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 233-246 HP_0003419 denotes low back pain
T2 237-246 HP_0003418 denotes back pain
T3 242-246 HP_0012531 denotes pain