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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 135-388 BACKGROUND denotes Aging and testosterone deficiency contribute to the pathogenesis of atrial fibrillation (AF). We determine the effects of testosterone replacement on the electrophysiology and arrhythmogenesis of pulmonary vein (PV) and left atrium (LA) in aged rabbits.
T2 398-619 METHODS denotes Electrocardiography, heart rate variability, echocardiography, Western blot and conventional microelectrodes were used in aged rabbits (age, >2 years) with and without (control) testosterone treatment (10mg/kg, 12 weeks).
T3 629-1830 RESULTS denotes Testosterone-treated aged rabbits had longer corrected QT interval, higher low frequency/high frequency, greater left ventricle (LV) mass but lower LA total emptying fraction and LV ejection fraction than control rabbits. In tissue preparations, the spontaneous rate was faster for testosterone-treated PVs than for control PVs. Angiotensin II concentration-dependently increased the amplitude of delayed afterdepolarizations (DADs) in testosterone-treated PVs but only did so at the highest angiotensin II concentration (100 nM) in control PVs. Isoproterenol increased the incidence of early afterdepolarizations (EADs) and DADs in testosterone-treated PVs but not in control PVs. Testosterone-treated PVs had more H2O2-induced burst firing and EADs than control PVs. Testosterone-treated LAs had more isoproterenol-induced DADs and spontaneous activity than did control LAs. However, acetylcholine infusion and rapid atrial pacing (10-20 Hz) induced AF in control LAs but not in testosterone-treated LAs. In addition, as compared with control LAs, testosterone-treated LAs expressed more androgen receptor, β1-adrenergic receptor, and Cav 1.2 and less G protein-coupled receptor kinase-2 and Kv 4.2.
T4 1844-1958 CONCLUSIONS denotes Testosterone replacement increased arrhythmogenesis in PV and LA by enhancing adrenergic activity in aged rabbits.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 113-121 CVCL_C410|Hybridoma|Mus musculus denotes activity
T2 229-231 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T3 534-537 CVCL_Z433|Spontaneously_immortalized_cell_line|Anthonomus grandis denotes age
T4 534-537 CVCL_Z658|Spontaneously_immortalized_cell_line|Anticarsia gemmatalis denotes age
T5 1475-1483 CVCL_C410|Hybridoma|Mus musculus denotes activity
T6 1566-1568 CVCL_J923|Hybridoma|Mus musculus denotes 20
T7 1766-1769 CVCL_LM72|Cancer_cell_line|Homo sapiens denotes Cav
T8 1770-1773 CVCL_0C53|Cancer_cell_line|Homo sapiens denotes 1.2
T9 1933-1941 CVCL_C410|Hybridoma|Mus musculus denotes activity

GoldHamster

Id Subject Object Predicate Lexical cue
T4 0-12 10379 denotes Testosterone
T1 0-12 D013739 denotes Testosterone
T2 0-12 CHEBI:17347 denotes Testosterone
T3 0-12 D013739 denotes Testosterone
T5 40-54 UBERON:0002016 denotes pulmonary vein
T7 59-70 UBERON:0002079 denotes left atrium
T10 135-140 GO:0007568 denotes Aging
T14 145-157 10379 denotes testosterone
T11 145-157 D013739 denotes testosterone
T12 145-157 CHEBI:17347 denotes testosterone
T13 145-157 D013739 denotes testosterone
T15 158-168 SO:1000029 denotes deficiency
T16 187-199 GO:0009405 denotes pathogenesis
T17 203-222 D001281 denotes atrial fibrillation
T18 203-222 D001281 denotes atrial fibrillation
T22 257-269 10379 denotes testosterone
T19 257-269 D013739 denotes testosterone
T20 257-269 CHEBI:17347 denotes testosterone
T21 257-269 D013739 denotes testosterone
T23 331-345 UBERON:0002016 denotes pulmonary vein
T25 355-366 UBERON:0002079 denotes left atrium
T28 380-387 D011817 denotes rabbits
T29 380-387 9986 denotes rabbits
T30 525-532 D011817 denotes rabbits
T31 525-532 9986 denotes rabbits
T35 576-588 10379 denotes testosterone
T32 576-588 D013739 denotes testosterone
T33 576-588 CHEBI:17347 denotes testosterone
T34 576-588 D013739 denotes testosterone
T39 629-641 10379 denotes Testosterone
T36 629-641 D013739 denotes Testosterone
T37 629-641 CHEBI:17347 denotes Testosterone
T38 629-641 D013739 denotes Testosterone
T40 655-662 D011817 denotes rabbits
T41 655-662 9986 denotes rabbits
T42 742-756 UBERON:0002084 denotes left ventricle
T44 842-849 D011817 denotes rabbits
T45 842-849 9986 denotes rabbits
T46 854-860 UBERON:0000479 denotes tissue
T50 911-923 10379 denotes testosterone
T47 911-923 D013739 denotes testosterone
T48 911-923 CHEBI:17347 denotes testosterone
T49 911-923 D013739 denotes testosterone
T51 932-935 PR:000002067 denotes PVs
T52 932-935 PR:P15151 denotes PVs
T53 932-935 PR:P32507 denotes PVs
T54 932-935 PR:000002069 denotes PVs
T55 953-956 PR:000002067 denotes PVs
T56 953-956 PR:P15151 denotes PVs
T57 953-956 PR:P32507 denotes PVs
T58 953-956 PR:000002069 denotes PVs
T68 958-972 PR:000036009 denotes Angiotensin II
T70 958-972 1999003 denotes Angiotensin II
T64 958-972 D000804 denotes Angiotensin II
T65 958-972 CHEBI:2719 denotes Angiotensin II
T66 958-972 D000804 denotes Angiotensin II
T67 958-972 CHEBI:58506 denotes Angiotensin II
T69 958-972 CHEBI:48432 denotes Angiotensin II
T71 1056-1060 C025953 denotes DADs
T72 1056-1060 C025953 denotes DADs
T76 1065-1077 10379 denotes testosterone
T73 1065-1077 D013739 denotes testosterone
T74 1065-1077 CHEBI:17347 denotes testosterone
T75 1065-1077 D013739 denotes testosterone
T77 1086-1089 PR:000002067 denotes PVs
T78 1086-1089 PR:P15151 denotes PVs
T79 1086-1089 PR:P32507 denotes PVs
T80 1086-1089 PR:000002069 denotes PVs
T90 1121-1135 PR:000036009 denotes angiotensin II
T92 1121-1135 1999003 denotes angiotensin II
T86 1121-1135 D000804 denotes angiotensin II
T87 1121-1135 CHEBI:2719 denotes angiotensin II
T88 1121-1135 D000804 denotes angiotensin II
T89 1121-1135 CHEBI:58506 denotes angiotensin II
T91 1121-1135 CHEBI:48432 denotes angiotensin II
T93 1170-1173 PR:000002067 denotes PVs
T94 1170-1173 PR:P15151 denotes PVs
T95 1170-1173 PR:P32507 denotes PVs
T96 1170-1173 PR:000002069 denotes PVs
T97 1175-1188 6054 denotes Isoproterenol
T98 1175-1188 D007545 denotes Isoproterenol
T99 1175-1188 D007545 denotes Isoproterenol
T100 1175-1188 CHEBI:64317 denotes Isoproterenol
T101 1175-1188 CHEBI:6257 denotes Isoproterenol
T102 1254-1258 C025953 denotes DADs
T103 1254-1258 C025953 denotes DADs
T107 1262-1274 10379 denotes testosterone
T104 1262-1274 D013739 denotes testosterone
T105 1262-1274 CHEBI:17347 denotes testosterone
T106 1262-1274 D013739 denotes testosterone
T108 1283-1286 PR:000002067 denotes PVs
T109 1283-1286 PR:P15151 denotes PVs
T110 1283-1286 PR:P32507 denotes PVs
T111 1283-1286 PR:000002069 denotes PVs
T112 1306-1309 PR:000002067 denotes PVs
T113 1306-1309 PR:P15151 denotes PVs
T114 1306-1309 PR:P32507 denotes PVs
T115 1306-1309 PR:000002069 denotes PVs
T119 1311-1323 10379 denotes Testosterone
T116 1311-1323 D013739 denotes Testosterone
T117 1311-1323 CHEBI:17347 denotes Testosterone
T118 1311-1323 D013739 denotes Testosterone
T120 1332-1335 PR:000002067 denotes PVs
T121 1332-1335 PR:P15151 denotes PVs
T122 1332-1335 PR:P32507 denotes PVs
T123 1332-1335 PR:000002069 denotes PVs
T126 1345-1349 CHEBI:16240 denotes H2O2
T127 1393-1396 PR:000002067 denotes PVs
T128 1393-1396 PR:P15151 denotes PVs
T129 1393-1396 PR:P32507 denotes PVs
T130 1393-1396 PR:000002069 denotes PVs
T134 1398-1410 10379 denotes Testosterone
T131 1398-1410 D013739 denotes Testosterone
T132 1398-1410 CHEBI:17347 denotes Testosterone
T133 1398-1410 D013739 denotes Testosterone
T135 1419-1422 PR:Q7JQW6 denotes LAs
T136 1419-1422 PR:Q9ZWC5 denotes LAs
T138 1419-1422 PR:000009798 denotes LAs
T139 1419-1422 PR:O43766 denotes LAs
T137 1419-1422 CHEBI:73525 denotes LAs
T140 1432-1445 6054 denotes isoproterenol
T141 1432-1445 D007545 denotes isoproterenol
T142 1432-1445 D007545 denotes isoproterenol
T143 1432-1445 CHEBI:64317 denotes isoproterenol
T144 1432-1445 CHEBI:6257 denotes isoproterenol
T145 1454-1458 C025953 denotes DADs
T146 1454-1458 C025953 denotes DADs
T147 1501-1504 PR:Q7JQW6 denotes LAs
T148 1501-1504 PR:Q9ZWC5 denotes LAs
T150 1501-1504 PR:000009798 denotes LAs
T151 1501-1504 PR:O43766 denotes LAs
T149 1501-1504 CHEBI:73525 denotes LAs
T153 1515-1528 194 denotes acetylcholine
T152 1515-1528 D000109 denotes acetylcholine
T154 1515-1528 CHEBI:15355 denotes acetylcholine
T155 1515-1528 D000109 denotes acetylcholine
T156 1595-1598 PR:Q7JQW6 denotes LAs
T157 1595-1598 PR:Q9ZWC5 denotes LAs
T159 1595-1598 PR:000009798 denotes LAs
T160 1595-1598 PR:O43766 denotes LAs
T158 1595-1598 CHEBI:73525 denotes LAs
T164 1610-1622 10379 denotes testosterone
T161 1610-1622 D013739 denotes testosterone
T162 1610-1622 CHEBI:17347 denotes testosterone
T163 1610-1622 D013739 denotes testosterone
T165 1631-1634 PR:Q7JQW6 denotes LAs
T166 1631-1634 PR:Q9ZWC5 denotes LAs
T168 1631-1634 PR:000009798 denotes LAs
T169 1631-1634 PR:O43766 denotes LAs
T167 1631-1634 CHEBI:73525 denotes LAs
T170 1674-1677 PR:Q7JQW6 denotes LAs
T171 1674-1677 PR:Q9ZWC5 denotes LAs
T173 1674-1677 PR:000009798 denotes LAs
T174 1674-1677 PR:O43766 denotes LAs
T172 1674-1677 CHEBI:73525 denotes LAs
T178 1679-1691 10379 denotes testosterone
T175 1679-1691 D013739 denotes testosterone
T176 1679-1691 CHEBI:17347 denotes testosterone
T177 1679-1691 D013739 denotes testosterone
T179 1700-1703 PR:Q7JQW6 denotes LAs
T180 1700-1703 PR:Q9ZWC5 denotes LAs
T182 1700-1703 PR:000009798 denotes LAs
T183 1700-1703 PR:O43766 denotes LAs
T181 1700-1703 CHEBI:73525 denotes LAs
T185 1719-1736 Q9GKL7 denotes androgen receptor
T186 1719-1736 Q9TT90 denotes androgen receptor
T188 1719-1736 O97775 denotes androgen receptor
T189 1719-1736 O97776 denotes androgen receptor
T190 1719-1736 Q7T1K4 denotes androgen receptor
T191 1719-1736 Q8MIK0 denotes androgen receptor
T192 1719-1736 Q6QT55 denotes androgen receptor
T193 1719-1736 P10275 denotes androgen receptor
T194 1719-1736 P19091 denotes androgen receptor
T195 1719-1736 PR:000004191 denotes androgen receptor
T196 1719-1736 O97960 denotes androgen receptor
T197 1719-1736 P15207 denotes androgen receptor
T198 1719-1736 O97952 denotes androgen receptor
T199 1719-1736 P49699 denotes androgen receptor
T187 1719-1736 D011944 denotes androgen receptor
T200 1741-1760 D011941 denotes adrenergic receptor
T201 1766-1769 12618 denotes Cav
T204 1766-1769 1051671 denotes Cav
T209 1766-1771 PR:Q03135 denotes Cav 1
T210 1766-1771 PR:P35431 denotes Cav 1
T211 1766-1771 PR:P49817 denotes Cav 1
T212 1766-1771 PR:P93025 denotes Cav 1
T214 1766-1771 PR:Q94051 denotes Cav 1
T215 1766-1771 PR:000003198 denotes Cav 1
T216 1766-1771 PR:P41350 denotes Cav 1
T213 1766-1771 CVCL_KR36 denotes Cav 1
T227 1783-1818 P25098 denotes G protein-coupled receptor kinase-2
T228 1783-1818 PR:000003791 denotes G protein-coupled receptor kinase-2
T229 1783-1818 Q99MK8 denotes G protein-coupled receptor kinase-2
T230 1783-1818 P26817 denotes G protein-coupled receptor kinase-2
T231 1783-1818 Q09639 denotes G protein-coupled receptor kinase-2
T232 1783-1818 O97627 denotes G protein-coupled receptor kinase-2
T233 1783-1818 P21146 denotes G protein-coupled receptor kinase-2
T235 1783-1818 Q64682 denotes G protein-coupled receptor kinase-2
T236 1783-1818 P32866 denotes G protein-coupled receptor kinase-2
T234 1783-1818 D054769 denotes G protein-coupled receptor kinase-2
T241 1785-1792 SO:0000104 denotes protein
T237 1785-1792 GO:0003675 denotes protein
T243 1823-1829 PR:000000947 denotes Kv 4.2
T247 1844-1856 10379 denotes Testosterone
T244 1844-1856 D013739 denotes Testosterone
T245 1844-1856 CHEBI:17347 denotes Testosterone
T246 1844-1856 D013739 denotes Testosterone
T248 1950-1957 D011817 denotes rabbits
T249 1950-1957 9986 denotes rabbits

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 203-222 HP_0005110 denotes atrial fibrillation

Allie

Id Subject Object Predicate Lexical cue
SS1_25037694_2_0 203-222 expanded denotes atrial fibrillation
SS2_25037694_2_0 224-226 abbr denotes AF
SS1_25037694_3_0 331-345 expanded denotes pulmonary vein
SS2_25037694_3_0 347-349 abbr denotes PV
SS1_25037694_3_1 355-366 expanded denotes left atrium
SS2_25037694_3_1 368-370 abbr denotes LA
SS1_25037694_7_0 742-756 expanded denotes left ventricle
SS2_25037694_7_0 758-760 abbr denotes LV
SS1_25037694_9_0 1026-1054 expanded denotes delayed afterdepolarizations
SS2_25037694_9_0 1056-1060 abbr denotes DADs
SS1_25037694_10_0 1216-1242 expanded denotes early afterdepolarizations
SS2_25037694_10_0 1244-1248 abbr denotes EADs
AE1_25037694_2_0 SS1_25037694_2_0 SS2_25037694_2_0 abbreviatedTo atrial fibrillation,AF
AE1_25037694_3_0 SS1_25037694_3_0 SS2_25037694_3_0 abbreviatedTo pulmonary vein,PV
AE1_25037694_3_1 SS1_25037694_3_1 SS2_25037694_3_1 abbreviatedTo left atrium,LA
AE1_25037694_7_0 SS1_25037694_7_0 SS2_25037694_7_0 abbreviatedTo left ventricle,LV
AE1_25037694_9_0 SS1_25037694_9_0 SS2_25037694_9_0 abbreviatedTo delayed afterdepolarizations,DADs
AE1_25037694_10_0 SS1_25037694_10_0 SS2_25037694_10_0 abbreviatedTo early afterdepolarizations,EADs