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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 67-238 DRI_Background denotes Tortuous carotid arteries are often seen in aged populations and are associated with atherosclerosis, but the underlying mechanisms to explain this preference are unclear.
T2 239-342 DRI_Background denotes Artery buckling has been suggested as one potential mechanism for the development of tortuous arteries.
T3 343-491 DRI_Background denotes The objective of this study, accordingly, was to determine the effect of buckling on cell proliferation and associated NF-κB activation in arteries.
T4 492-676 DRI_Outcome denotes We developed a technique to generate buckling in porcine carotid arteries using long artery segments in organ culture without changing the pressure, flow rate, and axial stretch ratio.
T5 677-825 DRI_Approach denotes Using this technique, we examined the effect of buckling on arterial wall remodeling in 4-day organ culture under normal and hypertensive pressures.
T6 826-960 DRI_Background denotes Cell proliferation, NF-κB p65, IκB-α, ERK1/2, and caspase-3 were detected using immunohistochemistry staining and immunoblot analysis.
T7 961-1186 DRI_Outcome denotes Our results showed that cell proliferation was elevated 5.8-fold in the buckling group under hypertensive pressure (n = 7, P < 0.01) with higher levels of NF-κB nuclear translocation and IκB-α degradation (P < 0.05 for both).
T8 1187-1334 DRI_Approach denotes Greater numbers of proliferating cells were observed on the inner curve side of the buckled arteries compared with the outer curve side (P < 0.01).
T9 1380-1556 DRI_Background denotes Computational simulations using a fluid-structure interaction model showed reduced wall stress on the inner side of buckled arteries and elevated wall stress on the outer side.
T10 1557-1686 DRI_Outcome denotes We conclude that arterial buckling promotes site-specific wall remodeling with increased cell proliferation and NF-κB activation.
T11 1687-1819 DRI_Background denotes These findings shed light on the biomechanical and molecular mechanisms of the pathogenesis of atherosclerosis in tortuous arteries.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 50-52 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T2 54-55 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T3 255-258 CVCL_6758|Undefined_cell_line_type|Cricetulus griseus denotes has
T4 255-258 CVCL_E689|Transformed_cell_line|Homo sapiens denotes has
T5 277-280 CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis denotes one
T6 462-464 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T7 466-467 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T8 468-478 CVCL_C410|Hybridoma|Mus musculus denotes activation
T9 492-494 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T10 505-506 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T11 618-626 CVCL_0238|Cancer_cell_line|Homo sapiens denotes changing
T12 699-701 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes we
T13 846-848 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T14 850-851 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T15 859-860 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T16 1077-1082 CVCL_D462|Transformed_cell_line|Mus musculus denotes n = 7
T17 1116-1118 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T18 1120-1121 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T19 1150-1151 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T20 1335-1337 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T21 1339-1340 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T22 1341-1352 CVCL_U289|Cancer_cell_line|Homo sapiens denotes colocalized
T23 1412-1413 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T24 1557-1559 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T25 1669-1671 CVCL_W770|Cancer_cell_line|Homo sapiens denotes NF
T26 1673-1674 CVCL_6480|Finite_cell_line|Mus musculus denotes B
T27 1675-1685 CVCL_C410|Hybridoma|Mus musculus denotes activation

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-6 UBERON:0001637 denotes Artery
T2 27-45 GO:0008283 denotes cell proliferation
T3 32-45 UBERON:2000098 denotes proliferation
T6 56-65 GO:0023052 denotes signaling
T7 76-83 UBERON:0005396 denotes carotid
T8 84-92 UBERON:0001637 denotes arteries
T9 152-167 D050197 denotes atherosclerosis
T10 152-167 D050197 denotes atherosclerosis
T11 239-245 UBERON:0001637 denotes Artery
T12 333-341 UBERON:0001637 denotes arteries
T13 428-446 GO:0008283 denotes cell proliferation
T14 433-446 UBERON:2000098 denotes proliferation
T17 482-490 UBERON:0001637 denotes arteries
T18 549-556 UBERON:0005396 denotes carotid
T19 557-565 UBERON:0001637 denotes arteries
T20 577-583 UBERON:0001637 denotes artery
T21 596-601 UBERON:0000062 denotes organ
T22 596-601 UBERON:0003103 denotes organ
T23 656-661 PR:Q07342 denotes axial
T24 737-750 UBERON:0000415 denotes arterial wall
T26 771-776 UBERON:0000062 denotes organ
T27 771-776 UBERON:0003103 denotes organ
T28 826-844 GO:0008283 denotes Cell proliferation
T29 831-844 UBERON:2000098 denotes proliferation
T32 852-855 P47191 denotes p65
T33 852-855 P46096 denotes p65
T34 852-855 Q49539 denotes p65
T35 852-855 PR:Q9FJR1 denotes p65
T36 852-855 P21707 denotes p65
T37 852-855 P48018 denotes p65
T38 852-855 PR:000017431 denotes p65
T39 852-855 P21521 denotes p65
T40 852-855 P41823 denotes p65
T41 852-855 PR:000015894 denotes p65
T42 852-855 P21579 denotes p65
T43 852-855 Q9H4A3 denotes p65
T49 864-868 Q63844 denotes ERK1
T50 864-868 P27361 denotes ERK1
T51 864-868 P21708 denotes ERK1
T52 864-868 PR:000000104 denotes ERK1
T53 864-868 PR:P42525 denotes ERK1
T54 864-868 Q5A1D3 denotes ERK1
T55 864-868 P42525 denotes ERK1
T56 864-868 PR:P27361 denotes ERK1
T57 864-868 PR:P21708 denotes ERK1
T59 864-868 PR:Q63844 denotes ERK1
T60 864-868 C4YGK0 denotes ERK1
T61 864-868 PR:Q5A1D3 denotes ERK1
T58 864-868 GO:0004707 denotes ERK1
T64 876-885 P55866 denotes caspase-3
T65 876-885 Q8MJC3 denotes caspase-3
T66 876-885 Q2PFV2 denotes caspase-3
T67 876-885 Q08DY9 denotes caspase-3
T68 876-885 Q5IS54 denotes caspase-3
T69 876-885 Q8MKI5 denotes caspase-3
T70 876-885 PR:000002312 denotes caspase-3
T71 876-885 Q8MJU1 denotes caspase-3
T72 876-885 Q60431 denotes caspase-3
T73 876-885 P42574 denotes caspase-3
T74 876-885 Q5IS99 denotes caspase-3
T75 876-885 Q95ND5 denotes caspase-3
T76 876-885 P70677 denotes caspase-3
T77 876-885 P55213 denotes caspase-3
T63 876-885 D053148 denotes caspase-3
T78 985-1003 GO:0008283 denotes cell proliferation
T79 990-1003 UBERON:2000098 denotes proliferation
T80 1021-1025 PR:000022679 denotes fold
T81 1021-1025 PR:Q2FZJ6 denotes fold
T82 1021-1025 PR:A5I112 denotes fold
T83 1021-1025 PR:P24186 denotes fold
T86 1130-1143 SO:0000199 denotes translocation
T89 1154-1165 GO:0009056 denotes degradation
T90 1279-1287 UBERON:0001637 denotes arteries
T93 1372-1378 CHEBI:33252 denotes nuclei
T94 1414-1419 UBERON:0006314 denotes fluid
T95 1463-1467 UBERON:0000060 denotes wall
T96 1504-1512 UBERON:0001637 denotes arteries
T97 1526-1530 UBERON:0000060 denotes wall
T98 1615-1619 UBERON:0000060 denotes wall
T99 1646-1664 GO:0008283 denotes cell proliferation
T100 1651-1664 UBERON:2000098 denotes proliferation
T103 1766-1778 GO:0009405 denotes pathogenesis
T104 1782-1797 D050197 denotes atherosclerosis
T105 1782-1797 D050197 denotes atherosclerosis
T106 1810-1818 UBERON:0001637 denotes arteries

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 67-92 HP_0005302 denotes Tortuous carotid arteries
T2 152-167 HP_0002621 denotes atherosclerosis
T3 802-814 HP_0000822 denotes hypertensive
T4 1054-1066 HP_0000822 denotes hypertensive
T5 1782-1797 HP_0002621 denotes atherosclerosis