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PubMed:24303782 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 638-642 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 344-357 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T2 1060-1073 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO
T3 1219-1232 Glycan_Motif denotes peptidoglycan https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00023MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-122 Sentence denotes Metabolomics analysis identifies d-Alanine-d-Alanine ligase as the primary lethal target of d-Cycloserine in mycobacteria.
T2 123-460 Sentence denotes d-Cycloserine is an effective second line antibiotic used as a last resort to treat multi (MDR)- and extensively (XDR) drug resistant strains of Mycobacterium tuberculosis . d-Cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of alanine racemase (Alr) and d-alanine-d-alanine ligase (Ddl).
T3 461-556 Sentence denotes Although the two enzymes are known to be inhibited, the in vivo lethal target is still unknown.
T4 557-715 Sentence denotes Our NMR metabolomics work has revealed that Ddl is the primary target of DCS, as cell growth is inhibited when the production of d-alanyl-d-alanine is halted.
T5 716-872 Sentence denotes It is shown that inhibition of Alr may contribute indirectly by lowering the levels of d-alanine, thus allowing DCS to outcompete d-alanine for Ddl binding.
T6 873-1028 Sentence denotes The NMR data also supports the possibility of a transamination reaction to produce d-alanine from pyruvate and glutamate, thereby bypassing Alr inhibition.
T7 1029-1244 Sentence denotes Furthermore, the inhibition of peptidoglycan synthesis results in a cascading effect on cellular metabolism as there is a shift toward the catabolic routes to compensate for accumulation of peptidoglycan precursors.
T1 0-122 Sentence denotes Metabolomics analysis identifies d-Alanine-d-Alanine ligase as the primary lethal target of d-Cycloserine in mycobacteria.
T2 123-460 Sentence denotes d-Cycloserine is an effective second line antibiotic used as a last resort to treat multi (MDR)- and extensively (XDR) drug resistant strains of Mycobacterium tuberculosis . d-Cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of alanine racemase (Alr) and d-alanine-d-alanine ligase (Ddl).
T3 461-556 Sentence denotes Although the two enzymes are known to be inhibited, the in vivo lethal target is still unknown.
T4 557-715 Sentence denotes Our NMR metabolomics work has revealed that Ddl is the primary target of DCS, as cell growth is inhibited when the production of d-alanyl-d-alanine is halted.
T5 716-872 Sentence denotes It is shown that inhibition of Alr may contribute indirectly by lowering the levels of d-alanine, thus allowing DCS to outcompete d-alanine for Ddl binding.
T6 873-1028 Sentence denotes The NMR data also supports the possibility of a transamination reaction to produce d-alanine from pyruvate and glutamate, thereby bypassing Alr inhibition.
T7 1029-1244 Sentence denotes Furthermore, the inhibition of peptidoglycan synthesis results in a cascading effect on cellular metabolism as there is a shift toward the catabolic routes to compensate for accumulation of peptidoglycan precursors.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 344-357 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T2 1060-1073 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan
T3 1219-1232 https://glytoucan.org/Structures/Glycans/G00023MO denotes peptidoglycan

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 638-642 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 282-294 Disease denotes tuberculosis http://purl.obolibrary.org/obo/MONDO_0018076

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 268-294 OrganismTaxon denotes Mycobacterium tuberculosis NCBItxid:1773

Allie

Id Subject Object Predicate Lexical cue
SS1_24303782_1_0 400-416 expanded denotes alanine racemase
SS2_24303782_1_0 418-421 abbr denotes Alr
SS1_24303782_1_1 427-453 expanded denotes d-alanine-d-alanine ligase
SS2_24303782_1_1 455-458 abbr denotes Ddl
AE1_24303782_1_0 SS1_24303782_1_0 SS2_24303782_1_0 abbreviatedTo alanine racemase,Alr
AE1_24303782_1_1 SS1_24303782_1_1 SS2_24303782_1_1 abbreviatedTo d-alanine-d-alanine ligase,Ddl