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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 174-515 BACKGROUND denotes Recent data suggested an interaction between plasma constituents and the endothelial glycocalyx to be relevant for vascular barrier function. This might be negatively influenced by infusion solutions, depending on ionic composition, pH and binding properties. The present study evaluated such an influence of current artificial preparations.
T2 525-1058 METHODS denotes Isolated guinea pig hearts were prepared in a modified Langendorff mode and perfused with Krebs-Henseleit buffer augmented with 1g% human albumin. After equilibration the perfusion was switched to replacement of one half buffer by either isotonic saline (NaCl), ringer's acetate (Ri-Ac), 6% and 10% hydroxyethyl starch (6% and 10% HES, resp.), or 4% gelatine (Gel), the artificial colloids having been prepared in balanced solution. We analysed glycocalyx shedding, functional integrity of the vascular barrier and heart performance.
T3 1068-2062 RESULTS denotes While glycocalyx shedding was not observed, diluting albumin concentration towards 0.5g% by artificial solutions was associated with a marked functional breakdown of vascular barrier competence. This effect was biggest with isotonic saline and significantly attenuated with artificial colloids, the difference in the pressure dependent transvascular fluid filtration (basal vs. during infusion in groups NaCl, Ri-Ac, 6% HES, 10% HES and Gel, n = 6 each) being 0.31 ± 0.03 vs. 1.00 ± 0.04; 0.27 ± 0.03 vs. 0.81 ± 0.03; 0.29 ± 0.03 vs. 0.68 ± 0.02; 0.32 ± 0.03 vs. 0.59 ± 0.08 and 0.31 ± 0.04 vs. 0.61 ± 0.03 g/5min, respectively. Heart performance was directly related to pH value (7.38 ± 0.06, 7.33 ± 0.03, 7.14 ± 0.04, 7.08 ± 0.04, 7.25 ± 0.03), the change in the rate pressure product being 21,702 ± 1969 vs. 21,291 ± 2,552; 22,098 ± 2,115 vs. 14,114 ± 3,386; 20,897 ± 2,083 vs. 10,671 ± 1,948; 21,822 ± 2,470 vs. 10,047 ± 2,320 and 20,955 ± 2,296 vs. 15,951 ± 2,755 mmHg × bpm, respectively.
T4 2076-2375 CONCLUSIONS denotes It appears important to maintain the pH value within a physiological range to maintain optimal myocardial contractility. Using colloids prepared in calcium-containing, balanced solutions for volume replacement therapy may attenuate the breakdown of vascular barrier competence in the critically ill.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 196-198 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T2 196-198 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T3 467-469 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T4 467-469 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T5 569-570 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T6 737-740 CVCL_Z424|Spontaneously_immortalized_cell_line|Ostrinia nubilalis denotes one
T7 808-810 CVCL_HA69|Transformed_cell_line|Homo sapiens denotes Ac
T8 813-822 CVCL_UM80|Cancer_cell_line|Homo sapiens denotes 6% and 10
T9 845-854 CVCL_UM80|Cancer_cell_line|Homo sapiens denotes 6% and 10
T10 958-960 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T11 1201-1202 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T12 1481-1483 CVCL_HA69|Transformed_cell_line|Homo sapiens denotes Ac
T13 1510-1515 CVCL_D461|Transformed_cell_line|Mus musculus denotes n = 6
T14 1819-1825 CVCL_0238|Cancer_cell_line|Homo sapiens denotes change
T15 2129-2130 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 2294-2297 CVCL_E773|Transformed_cell_line|Homo sapiens denotes may

GoldHamster

Id Subject Object Predicate Lexical cue
T1 4-10 PR:Q54JW9 denotes impact
T2 4-10 PR:Q642J4 denotes impact
T3 219-225 UBERON:0001969 denotes plasma
T4 259-269 GO:0030112 denotes glycocalyx
T5 414-421 SO:0100018 denotes binding
T6 414-421 SO:0001091 denotes binding
T7 414-421 GO:0005488 denotes binding
T8 491-501 32630 denotes artificial
T9 534-544 D006168 denotes guinea pig
T10 534-544 10141 denotes guinea pig
T12 541-544 P30941 denotes pig
T13 615-637 C074097 denotes Krebs-Henseleit buffer
T14 615-637 C074097 denotes Krebs-Henseleit buffer
T16 657-662 D006801 denotes human
T17 657-670 D000075462 denotes human albumin
T18 746-752 CHEBI:35225 denotes buffer
T19 780-784 CHEBI:26710 denotes NaCl
T20 787-803 C028570 denotes ringer's acetate
T22 796-803 164 denotes acetate
T24 808-814 Q03343 denotes Ac), 6
T27 808-814 Q01341 denotes Ac), 6
T25 808-814 C576651 denotes Ac), 6
T26 808-814 C576651 denotes Ac), 6
T28 824-843 5531 denotes hydroxyethyl starch
T29 837-843 D013213 denotes starch
T30 837-843 D013213 denotes starch
T32 837-843 CHEBI:28017 denotes starch
T33 856-859 D017681 denotes HES
T34 875-883 CHEBI:5291 denotes gelatine
T35 885-888 PR:Q07171 denotes Gel
T36 895-905 32630 denotes artificial
T37 906-914 D003102 denotes colloids
T38 906-914 D003102 denotes colloids
T39 948-956 CHEBI:75958 denotes solution
T40 970-980 GO:0030112 denotes glycocalyx
T41 1074-1084 GO:0030112 denotes glycocalyx
T42 1160-1170 32630 denotes artificial
T43 1221-1230 GO:0009056 denotes breakdown
T44 1342-1352 32630 denotes artificial
T45 1353-1361 D003102 denotes colloids
T46 1353-1361 D003102 denotes colloids
T47 1418-1423 UBERON:0006314 denotes fluid
T48 1472-1476 CHEBI:26710 denotes NaCl
T49 1481-1486 Q03343 denotes Ac, 6
T52 1481-1486 Q01341 denotes Ac, 6
T50 1481-1486 C576651 denotes Ac, 6
T51 1481-1486 C576651 denotes Ac, 6
T53 1488-1491 D017681 denotes HES
T54 1497-1500 D017681 denotes HES
T55 1505-1508 PR:Q07171 denotes Gel
T56 1678-1681 CVCL_E777 denotes min
T57 2203-2211 D003102 denotes colloids
T58 2203-2211 D003102 denotes colloids
T59 2224-2231 1895 denotes calcium
T60 2224-2231 CHEBI:29320 denotes calcium
T61 2224-2231 CHEBI:22984 denotes calcium
T62 2312-2321 GO:0009056 denotes breakdown
T63 2360-2374 D016638 denotes critically ill
T64 2360-2374 D016638 denotes critically ill

Allie

Id Subject Object Predicate Lexical cue
SS1_24034366_7_0 787-803 expanded denotes ringer's acetate
SS2_24034366_7_0 805-810 abbr denotes Ri-Ac
SS1_24034366_7_1 875-883 expanded denotes gelatine
SS2_24034366_7_1 885-888 abbr denotes Gel
AE1_24034366_7_0 SS1_24034366_7_0 SS2_24034366_7_0 abbreviatedTo ringer's acetate,Ri-Ac
AE1_24034366_7_1 SS1_24034366_7_1 SS2_24034366_7_1 abbreviatedTo gelatine,Gel