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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-367 Sentence denotes A randomized controlled trial investigating the effects of PCSO-524, a patented oil extract of the New Zealand green lipped mussel (Perna canaliculus), on the behaviour, mood, cognition and neurophysiology of children and adolescents (aged 6-14 years) experiencing clinical and sub-clinical levels of hyperactivity and inattention: study protocol ACTRN12610000978066.
T2 368-379 Sentence denotes BACKGROUND:
T3 380-661 Sentence denotes The prevalence rate of attention-deficit/hyperactivity disorder (ADHD) within Western cultures is between 5% and 12%, and is the most common psychiatric illness among school-aged children, with an estimated 50% of these children retaining ADHD symptoms for the rest of their lives.
T4 662-881 Sentence denotes Children with ADHD have lower blood levels of long-chain Poly Unsaturated Fatty Acids (LC PUFAs) compared with children without ADHD, and following PUFA supplementation, have shown improvements in ADHD-related symptoms.
T5 882-1222 Sentence denotes One highly promising marine based LC PUFA preparation is the Omega-3-rich Lyprinol/Omega XL which is a natural formulation containing standardised lipid extract of the New Zealand green lipped mussel (Perna canaliculus) known as PCSO-524® which contains a unique combination of free fatty acids, sterol esters, polar lipids and carotenoids.
T6 1223-1373 Sentence denotes It is this unique combination of marine lipids that may assist in correcting the decreased levels of LC PUFA levels in children with symptoms of ADHD.
T7 1374-1453 Sentence denotes The compound is a mixture belonging to a lipid group called sterol esters (SE).
T8 1454-1649 Sentence denotes The fatty acids in the SE fraction are mainly myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
T9 1650-1829 Sentence denotes Lyprinol/Omega XL has previously been shown to contain a potent group of Omega-3 lipids that block the 5 - lipoxygenase metabolic pathway responsible for inflammation in the body.
T10 1830-1838 Sentence denotes METHODS:
T11 1839-2077 Sentence denotes A randomized double blind placebo controlled trial will be utilized to assess the effects of 14 weeks administration of Lyprinol/Omega XL versus placebo in 150 children aged 6 to 14 years with high levels of hyperactivity and inattention.
T12 2078-2221 Sentence denotes Additionally, a range of cognitive, mood and central electrophysiological measures will be undertaken during the 14 week supplementation trial.
T13 2222-2409 Sentence denotes The primary outcome measure, the Conners' Parent Rating Scales will be completed initially at baseline, then in weeks 4, 8, 10, 14 and then again at 4 weeks post-administration (week 18).
T14 2410-2601 Sentence denotes The results will contribute to our understanding of the efficacy of marine based Omega-3 s with high anti-inflammatory actions on inattention and hyperactivity in children aged 6 to 14 years.
T1 0-367 Sentence denotes A randomized controlled trial investigating the effects of PCSO-524, a patented oil extract of the New Zealand green lipped mussel (Perna canaliculus), on the behaviour, mood, cognition and neurophysiology of children and adolescents (aged 6-14 years) experiencing clinical and sub-clinical levels of hyperactivity and inattention: study protocol ACTRN12610000978066.
T2 368-379 Sentence denotes BACKGROUND:
T3 380-661 Sentence denotes The prevalence rate of attention-deficit/hyperactivity disorder (ADHD) within Western cultures is between 5% and 12%, and is the most common psychiatric illness among school-aged children, with an estimated 50% of these children retaining ADHD symptoms for the rest of their lives.
T4 662-881 Sentence denotes Children with ADHD have lower blood levels of long-chain Poly Unsaturated Fatty Acids (LC PUFAs) compared with children without ADHD, and following PUFA supplementation, have shown improvements in ADHD-related symptoms.
T5 882-1222 Sentence denotes One highly promising marine based LC PUFA preparation is the Omega-3-rich Lyprinol/Omega XL which is a natural formulation containing standardised lipid extract of the New Zealand green lipped mussel (Perna canaliculus) known as PCSO-524® which contains a unique combination of free fatty acids, sterol esters, polar lipids and carotenoids.
T6 1223-1373 Sentence denotes It is this unique combination of marine lipids that may assist in correcting the decreased levels of LC PUFA levels in children with symptoms of ADHD.
T7 1374-1453 Sentence denotes The compound is a mixture belonging to a lipid group called sterol esters (SE).
T8 1454-1649 Sentence denotes The fatty acids in the SE fraction are mainly myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
T9 1650-1829 Sentence denotes Lyprinol/Omega XL has previously been shown to contain a potent group of Omega-3 lipids that block the 5 - lipoxygenase metabolic pathway responsible for inflammation in the body.
T10 1830-1838 Sentence denotes METHODS:
T11 1839-2077 Sentence denotes A randomized double blind placebo controlled trial will be utilized to assess the effects of 14 weeks administration of Lyprinol/Omega XL versus placebo in 150 children aged 6 to 14 years with high levels of hyperactivity and inattention.
T12 2078-2221 Sentence denotes Additionally, a range of cognitive, mood and central electrophysiological measures will be undertaken during the 14 week supplementation trial.
T13 2222-2409 Sentence denotes The primary outcome measure, the Conners' Parent Rating Scales will be completed initially at baseline, then in weeks 4, 8, 10, 14 and then again at 4 weeks post-administration (week 18).
T14 2410-2601 Sentence denotes The results will contribute to our understanding of the efficacy of marine based Omega-3 s with high anti-inflammatory actions on inattention and hyperactivity in children aged 6 to 14 years.

Allie

Id Subject Object Predicate Lexical cue
SS1_23866813_2_0 403-443 expanded denotes attention-deficit/hyperactivity disorder
SS2_23866813_2_0 445-449 abbr denotes ADHD
SS1_23866813_3_0 708-747 expanded denotes long-chain Poly Unsaturated Fatty Acids
SS2_23866813_3_0 749-757 abbr denotes LC PUFAs
SS1_23866813_6_0 1434-1447 expanded denotes sterol esters
SS2_23866813_6_0 1449-1451 abbr denotes SE
SS1_23866813_7_0 1589-1610 expanded denotes eicosapentaenoic acid
SS2_23866813_7_0 1612-1615 abbr denotes EPA
SS1_23866813_7_1 1622-1642 expanded denotes docosahexaenoic acid
SS2_23866813_7_1 1644-1647 abbr denotes DHA
AE1_23866813_2_0 SS1_23866813_2_0 SS2_23866813_2_0 abbreviatedTo attention-deficit/hyperactivity disorder,ADHD
AE1_23866813_3_0 SS1_23866813_3_0 SS2_23866813_3_0 abbreviatedTo long-chain Poly Unsaturated Fatty Acids,LC PUFAs
AE1_23866813_6_0 SS1_23866813_6_0 SS2_23866813_6_0 abbreviatedTo sterol esters,SE
AE1_23866813_7_0 SS1_23866813_7_0 SS2_23866813_7_0 abbreviatedTo eicosapentaenoic acid,EPA
AE1_23866813_7_1 SS1_23866813_7_1 SS2_23866813_7_1 abbreviatedTo docosahexaenoic acid,DHA

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 403-420 HP_0007018 denotes attention-deficit
T2 403-443 HP_0007018 denotes attention-deficit/hyperactivity disorder
T3 421-434 HP_0000752 denotes hyperactivity

Zierdiyeerkenaili_800_3

Id Subject Object Predicate Lexical cue
T1 1959-1976 CI denotes Lyprinol/Omega XL
T2 956-973 CI denotes Lyprinol/Omega XL
T3 1650-1667 CI denotes Lyprinol/Omega XL
T4 59-67 CI denotes PCSO-524
T5 1111-1120 CI denotes PCSO-524®
T6 1984-1991 CI denotes placebo
T7 1865-1872 CI denotes placebo

yaoziqian_800_3

Id Subject Object Predicate Lexical cue
T1 59-67 CI denotes PCSO-524
T17 1111-1120 CI denotes PCSO-524®
T19 1650-1667 CI denotes Lyprinol/Omega XL
T20 956-973 CI denotes Lyprinol/Omega XL
T21 1959-1976 CI denotes Lyprinol/Omega XL
T22 1865-1872 CI denotes placebo
T23 1984-1991 CI denotes placebo