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PubMed:23246576 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 156-545 BACKGROUND denotes Chemotherapeutic drug resistance remains a clinical obstacle in cancer management. Drug-resistant cancer cells usually exhibit cross-resistance to ionizing radiation, which has devastating consequences for patients. With a better understanding of the molecular mechanisms, it will be possible to develop strategies to overcome this cross-resistance and to increase therapeutic sensitivity.
T2 555-1078 METHODS denotes Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its radio-sensitizing activity on human breast cancer MCF-7 and adriamycin-resistant MCF-7 (MCF-7/ADR) cells. Chemo-sensitizing or radio-sensitizing effect was analyzed by tetrazolium-based colorimetric assay and flow cytometry. Western blot analysis, confocal microscopy, gene silencing with siRNA transfection and luciferase reporter gene assay were performed to examine signaling molecule activation.
T3 1088-1835 RESULTS denotes Among the tested flavonoid compounds, pretreatment of the cells with xanthohumol significantly sensitized MCF-7/ADR cells to the radiation treatment by inducing apoptosis. In MCF-7/ADR cells, treatment with xanthohumol alone or with gamma-rays significantly decreased levels of anti-apoptotic proteins. Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression levels in MCF-7/ADR cells were suppressed by xanthohumol treatment. In addition, xanthohumol treatment increased death receptor (DR)-4 and DR5 expression. The xanthohumol-induced changes of these resistance-related molecules in MCF-7/ADR cells were synergistically increased by gamma-ray treatment.
T4 1849-1940 CONCLUSIONS denotes Xanthohumol restored sensitivity of MCF-7/ADR cells to doxorubicin and radiation therapies.
T5 1963-2108 CONCLUSIONS denotes Our results suggest that xanthohumol may be a potent chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition.

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-143 Sentence denotes The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.
TextSentencer_T2 144-155 Sentence denotes BACKGROUND:
TextSentencer_T3 156-238 Sentence denotes Chemotherapeutic drug resistance remains a clinical obstacle in cancer management.
TextSentencer_T4 239-371 Sentence denotes Drug-resistant cancer cells usually exhibit cross-resistance to ionizing radiation, which has devastating consequences for patients.
TextSentencer_T5 372-545 Sentence denotes With a better understanding of the molecular mechanisms, it will be possible to develop strategies to overcome this cross-resistance and to increase therapeutic sensitivity.
TextSentencer_T6 546-554 Sentence denotes METHODS:
TextSentencer_T7 555-784 Sentence denotes Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its radio-sensitizing activity on human breast cancer MCF-7 and adriamycin-resistant MCF-7 (MCF-7/ADR) cells.
TextSentencer_T8 785-903 Sentence denotes Chemo-sensitizing or radio-sensitizing effect was analyzed by tetrazolium-based colorimetric assay and flow cytometry.
TextSentencer_T9 904-1078 Sentence denotes Western blot analysis, confocal microscopy, gene silencing with siRNA transfection and luciferase reporter gene assay were performed to examine signaling molecule activation.
TextSentencer_T10 1079-1087 Sentence denotes RESULTS:
TextSentencer_T11 1088-1259 Sentence denotes Among the tested flavonoid compounds, pretreatment of the cells with xanthohumol significantly sensitized MCF-7/ADR cells to the radiation treatment by inducing apoptosis.
TextSentencer_T12 1260-1390 Sentence denotes In MCF-7/ADR cells, treatment with xanthohumol alone or with gamma-rays significantly decreased levels of anti-apoptotic proteins.
TextSentencer_T13 1391-1604 Sentence denotes Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression levels in MCF-7/ADR cells were suppressed by xanthohumol treatment.
TextSentencer_T14 1605-1691 Sentence denotes In addition, xanthohumol treatment increased death receptor (DR)-4 and DR5 expression.
TextSentencer_T15 1692-1835 Sentence denotes The xanthohumol-induced changes of these resistance-related molecules in MCF-7/ADR cells were synergistically increased by gamma-ray treatment.
TextSentencer_T16 1836-1848 Sentence denotes CONCLUSIONS:
TextSentencer_T17 1849-1940 Sentence denotes Xanthohumol restored sensitivity of MCF-7/ADR cells to doxorubicin and radiation therapies.
TextSentencer_T18 1941-1962 Sentence denotes GENERAL SIGNIFICANCE:
TextSentencer_T19 1963-2108 Sentence denotes Our results suggest that xanthohumol may be a potent chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition.
T1 0-143 Sentence denotes The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells.
T2 144-155 Sentence denotes BACKGROUND:
T3 156-238 Sentence denotes Chemotherapeutic drug resistance remains a clinical obstacle in cancer management.
T4 239-371 Sentence denotes Drug-resistant cancer cells usually exhibit cross-resistance to ionizing radiation, which has devastating consequences for patients.
T5 372-545 Sentence denotes With a better understanding of the molecular mechanisms, it will be possible to develop strategies to overcome this cross-resistance and to increase therapeutic sensitivity.
T6 546-554 Sentence denotes METHODS:
T7 555-784 Sentence denotes Natural and synthetic flavonoid compounds including xanthohumol, the principal flavonoid in hops, were investigated for its radio-sensitizing activity on human breast cancer MCF-7 and adriamycin-resistant MCF-7 (MCF-7/ADR) cells.
T8 785-903 Sentence denotes Chemo-sensitizing or radio-sensitizing effect was analyzed by tetrazolium-based colorimetric assay and flow cytometry.
T9 904-1078 Sentence denotes Western blot analysis, confocal microscopy, gene silencing with siRNA transfection and luciferase reporter gene assay were performed to examine signaling molecule activation.
T10 1079-1087 Sentence denotes RESULTS:
T11 1088-1259 Sentence denotes Among the tested flavonoid compounds, pretreatment of the cells with xanthohumol significantly sensitized MCF-7/ADR cells to the radiation treatment by inducing apoptosis.
T12 1260-1390 Sentence denotes In MCF-7/ADR cells, treatment with xanthohumol alone or with gamma-rays significantly decreased levels of anti-apoptotic proteins.
T13 1391-1604 Sentence denotes Multi-drug resistance 1 (MDR1), epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3) expression levels in MCF-7/ADR cells were suppressed by xanthohumol treatment.
T14 1605-1691 Sentence denotes In addition, xanthohumol treatment increased death receptor (DR)-4 and DR5 expression.
T15 1692-1835 Sentence denotes The xanthohumol-induced changes of these resistance-related molecules in MCF-7/ADR cells were synergistically increased by gamma-ray treatment.
T16 1836-1848 Sentence denotes CONCLUSIONS:
T17 1849-1940 Sentence denotes Xanthohumol restored sensitivity of MCF-7/ADR cells to doxorubicin and radiation therapies.
T18 1941-1962 Sentence denotes GENERAL SIGNIFICANCE:
T19 1963-2108 Sentence denotes Our results suggest that xanthohumol may be a potent chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 69-73 gene:1956 denotes EGFR
T1 123-136 disease:C0006142 denotes breast cancer
T2 69-73 gene:1956 denotes EGFR
T3 123-136 disease:C0678222 denotes breast cancer
R1 T0 T1 associated_with EGFR,breast cancer
R2 T2 T3 associated_with EGFR,breast cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_23246576_12_0 1391-1414 expanded denotes Multi-drug resistance 1
SS2_23246576_12_0 1416-1420 abbr denotes MDR1
SS1_23246576_12_1 1423-1455 expanded denotes epidermal growth factor receptor
SS2_23246576_12_1 1457-1461 abbr denotes EGFR
SS1_23246576_12_2 1467-1517 expanded denotes signal transducer and activator of transcription 3
SS2_23246576_12_2 1519-1524 abbr denotes STAT3
SS1_23246576_13_0 1650-1664 expanded denotes death receptor
SS2_23246576_13_0 1666-1668 abbr denotes DR
AE1_23246576_12_0 SS1_23246576_12_0 SS2_23246576_12_0 abbreviatedTo Multi-drug resistance 1,MDR1
AE1_23246576_12_1 SS1_23246576_12_1 SS2_23246576_12_1 abbreviatedTo epidermal growth factor receptor,EGFR
AE1_23246576_12_2 SS1_23246576_12_2 SS2_23246576_12_2 abbreviatedTo signal transducer and activator of transcription 3,STAT3
AE1_23246576_13_0 SS1_23246576_13_0 SS2_23246576_13_0 abbreviatedTo death receptor,DR

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 220-226 HP_0002664 denotes cancer
T2 254-260 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
23246576-0#69#73#gene1956 69-73 gene1956 denotes EGFR
23246576-0#123#136#diseaseC0006142 123-136 diseaseC0006142 denotes breast cancer
23246576-0#123#136#diseaseC0678222 123-136 diseaseC0678222 denotes breast cancer
69#73#gene1956123#136#diseaseC0006142 23246576-0#69#73#gene1956 23246576-0#123#136#diseaseC0006142 associated_with EGFR,breast cancer
69#73#gene1956123#136#diseaseC0678222 23246576-0#69#73#gene1956 23246576-0#123#136#diseaseC0678222 associated_with EGFR,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2606 69-73 gene:1956 denotes EGFR
T2607 123-136 disease:C0006142 denotes breast cancer
R1 T2606 T2607 associated_with EGFR,breast cancer
R2 T2606 T2607 associated_with EGFR,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 123-129 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 715-721 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 123-129 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 715-721 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 123-136 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T2 220-226 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T3 244-260 Disease denotes resistant cancer http://purl.obolibrary.org/obo/MONDO_0036501
T4 715-728 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 117-122 OrganismTaxon denotes human 9606
T2 709-714 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 123-129 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 715-721 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 1423-1439 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021