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PubMed:22851870 JSONTXT

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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 100-222 OBJECTIVE denotes To evaluate the efficacy and safety of a hybrid bioartificial liver (HBAL) system in the treatment of acute liver failure.
T2 232-961 METHODS denotes Canine models with acute liver failure were introduced with intravenous administration of D-galactosamine. The animals were divided into: the HBAL treatment group (n = 8), in which the canines received a 3-h treatment of HBAL; the bioartificial liver (BAL) treatment group (n = 8), in which the canines received a 3-h treatment of BAL; the non-bioartificial liver (NBAL) treatment group (n = 8), in which the canines received a 3-h treatment of NBAL; the control group (n = 8), in which the canines received no additional treatment. Biochemical parameters and survival time were determined. Levels of xenoantibodies, RNA of porcine endogenous retrovirus (PERV) and reverse transcriptase (RT) activity in the plasma were detected.
T3 971-2005 RESULTS denotes Biochemical parameters were significantly decreased in all treatment groups. The TBIL level in the HBAL group was lower than that in other groups (2.19 ± 0.55 μmol/L vs 24.2 ± 6.45 μmol/L, 12.47 ± 3.62 μmol/L, 3.77 ± 1.83 μmol/L, P < 0.05). The prothrombin time (PT) in the BAL and HBAL groups was significantly shorter than the NBAL and control groups (18.47 ± 4.41 s, 15.5 ± 1.56 s vs 28.67 ± 5.71 s, 21.71 ± 3.4 s, P < 0.05), and the PT in the HBAL group was shortest of all the groups. The albumin in the BAL and HBAL groups significantly increased and a significantly higher level was observed in the HBAL group compared with the BAL group (27.7 ± 1.7 g/L vs 25.24 ± 1.93 g/L). In the HBAL group, the ammonia levels significantly decreased from 54.37 ± 6.86 to 37.75 ± 6.09 after treatment (P < 0.05); there were significant difference in ammonia levels between other the groups (P < 0.05). The levels of antibodies were similar before and after treatment. The PERV RNA and the RT activity in the canine plasma were all negative.
T4 2018-2101 CONCLUSIONS denotes The HBAL showed great efficiency and safety in the treatment of acute liver failure.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 14-15 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T2 58-59 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T3 77-82 CVCL_B488|Transformed_cell_line|Homo sapiens denotes plate
T4 139-140 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T5 396-401 CVCL_D463|Transformed_cell_line|Mus musculus denotes n = 8
T6 396-401 CVCL_IZ69|Spontaneously_immortalized_cell_line|Homo sapiens denotes n = 8
T7 434-437 CVCL_1061|Cancer_cell_line|Homo sapiens denotes a 3
T8 434-437 CVCL_1Q37|Spontaneously_immortalized_cell_line|Cricetulus griseus denotes a 3
T9 434-437 CVCL_5A61|Spontaneously_immortalized_cell_line|Cricetulus griseus denotes a 3
T10 434-437 CVCL_G649|Hybridoma|Mus musculus denotes a 3
T11 434-437 CVCL_JH29|Cancer_cell_line|Homo sapiens denotes a 3
T12 434-437 CVCL_LN35|Cancer_cell_line|Homo sapiens denotes a 3
T13 434-437 CVCL_ZU43|Transformed_cell_line|Homo sapiens denotes a 3
T14 434-435 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T15 506-511 CVCL_D463|Transformed_cell_line|Mus musculus denotes n = 8
T16 506-511 CVCL_IZ69|Spontaneously_immortalized_cell_line|Homo sapiens denotes n = 8
T17 544-547 CVCL_1061|Cancer_cell_line|Homo sapiens denotes a 3
T18 544-547 CVCL_1Q37|Spontaneously_immortalized_cell_line|Cricetulus griseus denotes a 3
T19 544-547 CVCL_5A61|Spontaneously_immortalized_cell_line|Cricetulus griseus denotes a 3
T20 544-547 CVCL_G649|Hybridoma|Mus musculus denotes a 3
T21 544-547 CVCL_JH29|Cancer_cell_line|Homo sapiens denotes a 3
T22 544-547 CVCL_LN35|Cancer_cell_line|Homo sapiens denotes a 3
T23 544-547 CVCL_ZU43|Transformed_cell_line|Homo sapiens denotes a 3
T24 544-545 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T25 620-625 CVCL_D463|Transformed_cell_line|Mus musculus denotes n = 8
T26 620-625 CVCL_IZ69|Spontaneously_immortalized_cell_line|Homo sapiens denotes n = 8
T27 658-661 CVCL_1061|Cancer_cell_line|Homo sapiens denotes a 3
T28 658-661 CVCL_1Q37|Spontaneously_immortalized_cell_line|Cricetulus griseus denotes a 3
T29 658-661 CVCL_5A61|Spontaneously_immortalized_cell_line|Cricetulus griseus denotes a 3
T30 658-661 CVCL_G649|Hybridoma|Mus musculus denotes a 3
T31 658-661 CVCL_JH29|Cancer_cell_line|Homo sapiens denotes a 3
T32 658-661 CVCL_LN35|Cancer_cell_line|Homo sapiens denotes a 3
T33 658-661 CVCL_ZU43|Transformed_cell_line|Homo sapiens denotes a 3
T34 658-659 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T35 702-707 CVCL_D463|Transformed_cell_line|Mus musculus denotes n = 8
T36 702-707 CVCL_IZ69|Spontaneously_immortalized_cell_line|Homo sapiens denotes n = 8
T37 801-805 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T38 924-932 CVCL_C410|Hybridoma|Mus musculus denotes activity
T39 1228-1232 CVCL_0047|Telomerase_immortalized_cell_line|Homo sapiens denotes time
T40 1386-1390 CVCL_1Y11|Transformed_cell_line|Homo sapiens denotes s, P
T41 1386-1390 CVCL_L986|Undefined_cell_line_type|Aotus trivirgatus denotes s, P
T42 1528-1529 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T43 1628-1631 CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara denotes g/L
T44 1648-1651 CVCL_R903|Spontaneously_immortalized_cell_line|Epinephelus awoara denotes g/L
T45 1957-1965 CVCL_C410|Hybridoma|Mus musculus denotes activity

GoldHamster

Id Subject Object Predicate Lexical cue
T1 22-28 37965 denotes hybrid
T2 22-28 D002678 denotes hybrid
T3 43-48 UBERON:0002107 denotes liver
T4 66-71 UBERON:0000119 denotes layer
T5 66-71 UBERON:0022303 denotes layer
T6 77-82 UBERON:6004475 denotes plate
T7 77-82 UBERON:0003148 denotes plate
T8 141-147 37965 denotes hybrid
T9 141-147 D002678 denotes hybrid
T10 162-167 UBERON:0002107 denotes liver
T11 202-221 D017114 denotes acute liver failure
T12 202-221 D017114 denotes acute liver failure
T13 208-213 UBERON:0002107 denotes liver
T16 232-238 UBERON:0003674 denotes Canine
T17 251-270 D017114 denotes acute liver failure
T18 251-270 D017114 denotes acute liver failure
T19 257-262 UBERON:0002107 denotes liver
T22 322-337 CHEBI:144817 denotes D-galactosamine
T23 322-337 CHEBI:60313 denotes D-galactosamine
T24 322-337 CHEBI:60312 denotes D-galactosamine
T25 322-337 CHEBI:28328 denotes D-galactosamine
T30 434-439 Q6NTF7 denotes a 3-h
T31 477-482 UBERON:0002107 denotes liver
T32 484-487 PR:000005317 denotes BAL
T33 484-487 P30122 denotes BAL
T34 484-487 PR:000015049 denotes BAL
T35 484-487 Q9PSN0 denotes BAL
T36 484-487 Q4LDG0 denotes BAL
T37 484-487 PR:P19835 denotes BAL
T38 484-487 Q64285 denotes BAL
T39 484-487 PR:000012301 denotes BAL
T41 484-487 PR:Q8CAS9 denotes BAL
T42 484-487 PR:O23530 denotes BAL
T43 484-487 P07882 denotes BAL
T44 484-487 PR:Q8IXQ6 denotes BAL
T45 484-487 Q9ES38 denotes BAL
T46 484-487 PR:Q58FX0 denotes BAL
T47 484-487 P19835 denotes BAL
T48 484-487 Q9Y2P5 denotes BAL
T40 484-487 CHEBI:64198 denotes BAL
T49 544-549 Q6NTF7 denotes a 3-h
T50 563-566 PR:000005317 denotes BAL
T51 563-566 P30122 denotes BAL
T52 563-566 PR:000015049 denotes BAL
T53 563-566 Q9PSN0 denotes BAL
T54 563-566 Q4LDG0 denotes BAL
T55 563-566 PR:P19835 denotes BAL
T56 563-566 Q64285 denotes BAL
T57 563-566 PR:000012301 denotes BAL
T59 563-566 PR:Q8CAS9 denotes BAL
T60 563-566 PR:O23530 denotes BAL
T61 563-566 P07882 denotes BAL
T62 563-566 PR:Q8IXQ6 denotes BAL
T63 563-566 Q9ES38 denotes BAL
T64 563-566 PR:Q58FX0 denotes BAL
T65 563-566 P19835 denotes BAL
T66 563-566 Q9Y2P5 denotes BAL
T58 563-566 CHEBI:64198 denotes BAL
T67 590-595 UBERON:0002107 denotes liver
T68 658-663 Q6NTF7 denotes a 3-h
T69 833-847 D000910 denotes xenoantibodies
T73 849-852 SO:0000356 denotes RNA
T70 849-852 CHEBI:33697 denotes RNA
T71 849-852 D012313 denotes RNA
T72 849-852 GO:0005562 denotes RNA
T74 864-885 D020077 denotes endogenous retrovirus
T77 897-904 SO:0001031 denotes reverse
T78 897-918 P23072 denotes reverse transcriptase
T79 897-918 P21329 denotes reverse transcriptase
T80 897-918 P23071 denotes reverse transcriptase
T81 897-918 P21328 denotes reverse transcriptase
T83 897-918 P23070 denotes reverse transcriptase
T84 897-918 Q9NBX4 denotes reverse transcriptase
T85 897-918 Q95SX7 denotes reverse transcriptase
T82 897-918 D012194 denotes reverse transcriptase
T91 905-918 GO:0003968 denotes transcriptase
T169 905-918 GO:0003899 denotes transcriptase
T193 905-918 GO:0034062 denotes transcriptase
T210 940-946 UBERON:0001969 denotes plasma
T212 1157-1162 PR:O76021 denotes L, 12
T213 1157-1162 PR:000029723 denotes L, 12
T214 1157-1162 P52855 denotes L, 12
T211 1157-1162 CVCL_WL12 denotes L, 12
T215 1216-1227 1441689 denotes prothrombin
T226 1216-1227 1441688 denotes prothrombin
T216 1216-1227 PR:000007299 denotes prothrombin
T217 1216-1227 Q19AZ8 denotes prothrombin
T218 1216-1227 P19221 denotes prothrombin
T219 1216-1227 Q5R537 denotes prothrombin
T221 1216-1227 P18292 denotes prothrombin
T222 1216-1227 P00735 denotes prothrombin
T224 1216-1227 P00734 denotes prothrombin
T220 1216-1227 D011516 denotes prothrombin
T223 1216-1227 CHEBI:8583 denotes prothrombin
T225 1216-1227 D011516 denotes prothrombin
T227 1245-1248 PR:000005317 denotes BAL
T228 1245-1248 P30122 denotes BAL
T229 1245-1248 PR:000015049 denotes BAL
T230 1245-1248 Q9PSN0 denotes BAL
T231 1245-1248 Q4LDG0 denotes BAL
T232 1245-1248 PR:P19835 denotes BAL
T233 1245-1248 Q64285 denotes BAL
T234 1245-1248 PR:000012301 denotes BAL
T236 1245-1248 PR:Q8CAS9 denotes BAL
T237 1245-1248 PR:O23530 denotes BAL
T238 1245-1248 P07882 denotes BAL
T239 1245-1248 PR:Q8IXQ6 denotes BAL
T240 1245-1248 Q9ES38 denotes BAL
T241 1245-1248 PR:Q58FX0 denotes BAL
T242 1245-1248 P19835 denotes BAL
T243 1245-1248 Q9Y2P5 denotes BAL
T235 1245-1248 CHEBI:64198 denotes BAL
T244 1338-1343 PR:P07185 denotes s, 15
T245 1338-1343 P33192 denotes s, 15
T246 1371-1376 Q01855 denotes s, 21
T247 1371-1376 CVCL_K245 denotes s, 21
T248 1480-1483 PR:000005317 denotes BAL
T249 1480-1483 P30122 denotes BAL
T250 1480-1483 PR:000015049 denotes BAL
T251 1480-1483 Q9PSN0 denotes BAL
T252 1480-1483 Q4LDG0 denotes BAL
T253 1480-1483 PR:P19835 denotes BAL
T254 1480-1483 Q64285 denotes BAL
T255 1480-1483 PR:000012301 denotes BAL
T257 1480-1483 PR:Q8CAS9 denotes BAL
T258 1480-1483 PR:O23530 denotes BAL
T259 1480-1483 P07882 denotes BAL
T260 1480-1483 PR:Q8IXQ6 denotes BAL
T261 1480-1483 Q9ES38 denotes BAL
T262 1480-1483 PR:Q58FX0 denotes BAL
T263 1480-1483 P19835 denotes BAL
T264 1480-1483 Q9Y2P5 denotes BAL
T256 1480-1483 CHEBI:64198 denotes BAL
T265 1606-1609 PR:000005317 denotes BAL
T266 1606-1609 P30122 denotes BAL
T267 1606-1609 PR:000015049 denotes BAL
T268 1606-1609 Q9PSN0 denotes BAL
T269 1606-1609 Q4LDG0 denotes BAL
T270 1606-1609 PR:P19835 denotes BAL
T271 1606-1609 Q64285 denotes BAL
T272 1606-1609 PR:000012301 denotes BAL
T274 1606-1609 PR:Q8CAS9 denotes BAL
T275 1606-1609 PR:O23530 denotes BAL
T276 1606-1609 P07882 denotes BAL
T277 1606-1609 PR:Q8IXQ6 denotes BAL
T278 1606-1609 Q9ES38 denotes BAL
T279 1606-1609 PR:Q58FX0 denotes BAL
T280 1606-1609 P19835 denotes BAL
T281 1606-1609 Q9Y2P5 denotes BAL
T273 1606-1609 CHEBI:64198 denotes BAL
T282 1677-1684 1299884 denotes ammonia
T283 1677-1684 CHEBI:16134 denotes ammonia
T284 1677-1684 D000641 denotes ammonia
T285 1677-1684 D000641 denotes ammonia
T286 1815-1822 1299884 denotes ammonia
T287 1815-1822 CHEBI:16134 denotes ammonia
T288 1815-1822 D000641 denotes ammonia
T289 1815-1822 D000641 denotes ammonia
T290 1881-1891 D000906 denotes antibodies
T293 1942-1945 GO:0005562 denotes RNA
T294 1942-1945 SO:0000356 denotes RNA
T291 1942-1945 CHEBI:33697 denotes RNA
T292 1942-1945 D012313 denotes RNA
T295 1973-1979 UBERON:0003674 denotes canine
T296 1980-1986 UBERON:0001969 denotes plasma
T297 2081-2100 D017114 denotes acute liver failure
T298 2081-2100 D017114 denotes acute liver failure
T299 2087-2092 UBERON:0002107 denotes liver

Allie

Id Subject Object Predicate Lexical cue
SS1_22851870_2_0 141-167 expanded denotes hybrid bioartificial liver
SS2_22851870_2_0 169-173 abbr denotes HBAL
SS1_22851870_5_0 463-482 expanded denotes bioartificial liver
SS2_22851870_5_0 484-487 abbr denotes BAL
SS1_22851870_5_1 572-595 expanded denotes non-bioartificial liver
SS2_22851870_5_1 597-601 abbr denotes NBAL
SS1_22851870_7_0 856-885 expanded denotes porcine endogenous retrovirus
SS2_22851870_7_0 887-891 abbr denotes PERV
SS1_22851870_7_1 897-918 expanded denotes reverse transcriptase
SS2_22851870_7_1 920-922 abbr denotes RT
SS1_22851870_11_0 1216-1232 expanded denotes prothrombin time
SS2_22851870_11_0 1234-1236 abbr denotes PT
AE1_22851870_2_0 SS1_22851870_2_0 SS2_22851870_2_0 abbreviatedTo hybrid bioartificial liver,HBAL
AE1_22851870_5_0 SS1_22851870_5_0 SS2_22851870_5_0 abbreviatedTo bioartificial liver,BAL
AE1_22851870_5_1 SS1_22851870_5_1 SS2_22851870_5_1 abbreviatedTo non-bioartificial liver,NBAL
AE1_22851870_7_0 SS1_22851870_7_0 SS2_22851870_7_0 abbreviatedTo porcine endogenous retrovirus,PERV
AE1_22851870_7_1 SS1_22851870_7_1 SS2_22851870_7_1 abbreviatedTo reverse transcriptase,RT
AE1_22851870_11_0 SS1_22851870_11_0 SS2_22851870_11_0 abbreviatedTo prothrombin time,PT

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 202-221 HP_0006554 denotes acute liver failure
T2 208-221 HP_0001399 denotes liver failure