PubMed:22611158 JSONTXT

{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"2","span":{"begin":0,"end":6},"obj":"GeneOrGeneProduct"},{"id":"3","span":{"begin":35,"end":40},"obj":"OrganismTaxon"},{"id":"16","span":{"begin":108,"end":113},"obj":"OrganismTaxon"},{"id":"17","span":{"begin":157,"end":162},"obj":"GeneOrGeneProduct"},{"id":"18","span":{"begin":255,"end":261},"obj":"GeneOrGeneProduct"},{"id":"19","span":{"begin":272,"end":277},"obj":"GeneOrGeneProduct"},{"id":"20","span":{"begin":280,"end":285},"obj":"GeneOrGeneProduct"},{"id":"21","span":{"begin":363,"end":369},"obj":"GeneOrGeneProduct"},{"id":"22","span":{"begin":371,"end":375},"obj":"GeneOrGeneProduct"},{"id":"23","span":{"begin":389,"end":394},"obj":"GeneOrGeneProduct"},{"id":"24","span":{"begin":557,"end":561},"obj":"GeneOrGeneProduct"},{"id":"25","span":{"begin":777,"end":781},"obj":"GeneOrGeneProduct"},{"id":"26","span":{"begin":811,"end":815},"obj":"GeneOrGeneProduct"},{"id":"27","span":{"begin":898,"end":902},"obj":"GeneOrGeneProduct"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Gene:8862"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:9606"},{"id":"A16","pred":"tao:has_database_id","subj":"16","obj":"Tax:9606"},{"id":"A17","pred":"tao:has_database_id","subj":"17","obj":"Gene:83881"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Gene:8862"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Gene:187"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"Gene:187"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:8862"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:8862"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:187"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:8862"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:8862"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:7422"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:8862"}],"text":"APELIN promotes hematopoiesis from human embryonic stem cells.\nTranscriptional profiling of differentiating human embryonic stem cells (hESCs) revealed that MIXL1-positive mesodermal precursors were enriched for transcripts encoding the G-protein-coupled APELIN receptor (APLNR). APLNR-positive cells, identified by binding of the fluoresceinated peptide ligand, APELIN (APLN), or an anti-APLNR mAb, were found in both posterior mesoderm and anterior mesendoderm populations and were enriched in hemangioblast colony-forming cells (Bl-CFC). The addition of APLN peptide to the media enhanced the growth of embryoid bodies (EBs), increased the expression of hematoendothelial genes in differentiating hESCs, and increased the frequency of Bl-CFCs by up to 10-fold. Furthermore, APLN peptide also synergized with VEGF to promote the growth of hESC-derived endothelial cells. These studies identified APLN as a novel growth factor for hESC-derived hematopoietic and endothelial cells."}

{"project":"Allie","denotations":[{"id":"SS1_22611158_1_0","span":{"begin":108,"end":134},"obj":"expanded"},{"id":"SS2_22611158_1_0","span":{"begin":136,"end":141},"obj":"abbr"},{"id":"SS1_22611158_1_1","span":{"begin":255,"end":270},"obj":"expanded"},{"id":"SS2_22611158_1_1","span":{"begin":272,"end":277},"obj":"abbr"},{"id":"SS1_22611158_2_0","span":{"begin":363,"end":369},"obj":"expanded"},{"id":"SS2_22611158_2_0","span":{"begin":371,"end":375},"obj":"abbr"},{"id":"SS1_22611158_3_0","span":{"begin":606,"end":621},"obj":"expanded"},{"id":"SS2_22611158_3_0","span":{"begin":623,"end":626},"obj":"abbr"}],"relations":[{"id":"AE1_22611158_1_0","pred":"abbreviatedTo","subj":"SS1_22611158_1_0","obj":"SS2_22611158_1_0"},{"id":"AE1_22611158_1_1","pred":"abbreviatedTo","subj":"SS1_22611158_1_1","obj":"SS2_22611158_1_1"},{"id":"AE1_22611158_2_0","pred":"abbreviatedTo","subj":"SS1_22611158_2_0","obj":"SS2_22611158_2_0"},{"id":"AE1_22611158_3_0","pred":"abbreviatedTo","subj":"SS1_22611158_3_0","obj":"SS2_22611158_3_0"}],"text":"APELIN promotes hematopoiesis from human embryonic stem cells.\nTranscriptional profiling of differentiating human embryonic stem cells (hESCs) revealed that MIXL1-positive mesodermal precursors were enriched for transcripts encoding the G-protein-coupled APELIN receptor (APLNR). APLNR-positive cells, identified by binding of the fluoresceinated peptide ligand, APELIN (APLN), or an anti-APLNR mAb, were found in both posterior mesoderm and anterior mesendoderm populations and were enriched in hemangioblast colony-forming cells (Bl-CFC). The addition of APLN peptide to the media enhanced the growth of embryoid bodies (EBs), increased the expression of hematoendothelial genes in differentiating hESCs, and increased the frequency of Bl-CFCs by up to 10-fold. Furthermore, APLN peptide also synergized with VEGF to promote the growth of hESC-derived endothelial cells. These studies identified APLN as a novel growth factor for hESC-derived hematopoietic and endothelial cells."}