PubMed:22539006 / 617-813
Annnotations
PubTator4TogoVar
| Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
|---|---|---|---|---|---|
| 22539006_3 | 22-28 | ProteinMutation | denotes | G2019S | rs34637584 |
c_corpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 30-38 | SO:0000109 | denotes | mutation |
| T80 | 49-54 | PR:Q5S006 | denotes | LRRK2 |
| T81 | 49-54 | PR:000003033 | denotes | LRRK2 |
| T82 | 49-54 | PR:Q5S007 | denotes | LRRK2 |
| T83 | 55-70 | GO:0016301 | denotes | kinase activity |
| T84 | 106-116 | SO:0001633 | denotes | downstream |
| T89 | 117-121 | GO:0004707 | denotes | MAPK |
| T92 | 117-128 | P10506 | denotes | MAPK kinase |
| T93 | 130-133 | GO:0004708 | denotes | MKK |
| T94 | 181-187 | SO:0000725 | denotes | signal |
| T95 | 181-187 | SO:0000418 | denotes | signal |
| T96 | 188-195 | CHEBI:34922 | denotes | pathway |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_22539006_4_0 | 117-128 | expanded | denotes | MAPK kinase |
| SS2_22539006_4_0 | 130-133 | abbr | denotes | MKK |
| AE1_22539006_4_0 | SS1_22539006_4_0 | SS2_22539006_4_0 | abbreviatedTo | MAPK kinase,MKK |
UseCases_ArguminSci_Discourse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T5 | 0-196 | DRI_Challenge | denotes | We hypothesized that (G2019S) mutation augmented LRRK2 kinase activity, leading to overphosphorylation of downstream MAPK kinase (MKK) and resulting in activation of neuronal death signal pathway. |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-196 | DRI_Challenge | denotes | We hypothesized that (G2019S) mutation augmented LRRK2 kinase activity, leading to overphosphorylation of downstream MAPK kinase (MKK) and resulting in activation of neuronal death signal pathway. |