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PubMed:22061999 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 204-211 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 1302-1309 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 1468-1474 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 204-211 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 1302-1309 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T3 1468-1474 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 204-211 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 1302-1309 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T3 1468-1474 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 867-875 http://purl.obolibrary.org/obo/MAT_0000348 denotes apoplast

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 110-116 FMAID:214748 denotes plants
_T2 173-180 FMAID:165447 denotes protein
_T3 173-180 FMAID:67257 denotes protein
_T4 204-211 FMAID:82801 denotes mannose
_T5 204-211 FMAID:196796 denotes mannose
_T6 315-324 FMAID:63836 denotes lysosomal
_T7 315-324 FMAID:162299 denotes lysosomal
_T8 503-523 FMAID:82787 denotes N-acetylglucosaminyl
_T9 503-523 FMAID:196781 denotes N-acetylglucosaminyl
_T10 585-594 FMAID:162299 denotes lysosomal
_T11 585-594 FMAID:63836 denotes lysosomal
_T12 666-670 FMAID:198663 denotes gene
_T13 696-700 FMAID:198663 denotes gene
_T14 799-801 FMAID:63498 denotes C5
_T15 799-801 FMAID:167723 denotes C5
_T16 1302-1309 FMAID:196796 denotes mannose
_T17 1302-1309 FMAID:82801 denotes mannose
_T18 1381-1386 FMAID:214748 denotes plant
_T19 1453-1459 FMAID:82804 denotes xylose
_T20 1453-1459 FMAID:196799 denotes xylose
_T21 1468-1474 FMAID:82790 denotes fucose
_T22 1468-1474 FMAID:196784 denotes fucose
_T23 1535-1546 FMAID:167685 denotes macrophages
_T24 1535-1546 FMAID:63261 denotes macrophages
_T25 1649-1660 FMAID:196728 denotes amino acids
_T26 1649-1660 FMAID:82739 denotes amino acids
_T27 1693-1700 FMAID:165447 denotes protein
_T28 1693-1700 FMAID:67257 denotes protein
_T29 1780-1787 FMAID:67257 denotes protein
_T30 1780-1787 FMAID:165447 denotes protein
_T31 1834-1839 FMAID:214748 denotes plant

uniprot-human

Id Subject Object Predicate Lexical cue
T1 325-343 http://www.uniprot.org/uniprot/Q6I9R6 denotes acid β-glucosidase
T2 375-383 http://www.uniprot.org/uniprot/Q6I9R6 denotes 3.2.1.45
T3 1075-1087 http://www.uniprot.org/uniprot/Q6I9R6 denotes imiglucerase
T4 1570-1582 http://www.uniprot.org/uniprot/Q6I9R6 denotes imiglucerase
T5 375-383 http://www.uniprot.org/uniprot/Q9HCG7 denotes 3.2.1.45
T6 503-535 http://www.uniprot.org/uniprot/Q09328 denotes N-acetylglucosaminyl transferase
T7 503-535 http://www.uniprot.org/uniprot/Q3V5L5 denotes N-acetylglucosaminyl transferase
T8 524-535 http://www.uniprot.org/uniprot/Q99484 denotes transferase
T9 542-551 http://www.uniprot.org/uniprot/P26572 denotes 2.4.1.101
T10 799-801 http://www.uniprot.org/uniprot/P01031 denotes C5

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 325-343 http://www.uniprot.org/uniprot/P17439 denotes acid β-glucosidase
T2 375-383 http://www.uniprot.org/uniprot/P17439 denotes 3.2.1.45
T3 375-383 http://www.uniprot.org/uniprot/Q69ZF3 denotes 3.2.1.45
T4 524-535 http://www.uniprot.org/uniprot/P38649 denotes transferase
T5 542-551 http://www.uniprot.org/uniprot/P27808 denotes 2.4.1.101
T6 799-801 http://www.uniprot.org/uniprot/P06684 denotes C5

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 58-69 http://purl.bioontology.org/ontology/NCBITAXON/3701 denotes Arabidopsis
T2 58-69 http://purl.bioontology.org/ontology/NCBITAXON/1150658 denotes Arabidopsis
T3 58-78 http://purl.bioontology.org/ontology/NCBITAXON/3702 denotes Arabidopsis thaliana
T4 70-78 http://purl.bioontology.org/ontology/NCBITAXON/96513 denotes thaliana
T5 404-415 http://purl.bioontology.org/ontology/NCBITAXON/3701 denotes Arabidopsis
T6 404-415 http://purl.bioontology.org/ontology/NCBITAXON/1150658 denotes Arabidopsis
T7 404-424 http://purl.bioontology.org/ontology/NCBITAXON/3702 denotes Arabidopsis thaliana
T8 416-424 http://purl.bioontology.org/ontology/NCBITAXON/96513 denotes thaliana
T9 1002-1009 http://purl.bioontology.org/ontology/NCBITAXON/68933 denotes thermal
T10 1637-1640 http://purl.bioontology.org/ontology/NCBITAXON/604139 denotes non

GO-BP

Id Subject Object Predicate Lexical cue
T1 491-523 http://purl.obolibrary.org/obo/GO_0003976 denotes activity of N-acetylglucosaminyl
T2 595-602 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T3 595-602 http://purl.obolibrary.org/obo/GO_0035732 denotes storage
T4 1498-1504 http://purl.obolibrary.org/obo/GO_0098657 denotes Uptake

GO-CC

Id Subject Object Predicate Lexical cue
T1 315-324 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T2 585-594 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T3 867-875 http://purl.obolibrary.org/obo/GO_0048046 denotes apoplast

Allie

Id Subject Object Predicate Lexical cue
SS1_22061999_0_0 79-103 expanded denotes complex-glycan-deficient
SS2_22061999_0_0 105-108 abbr denotes cgl
SS1_22061999_2_0 425-449 expanded denotes complex-glycan-deficient
SS2_22061999_2_0 451-454 abbr denotes cgl
AE1_22061999_0_0 SS1_22061999_0_0 SS2_22061999_0_0 abbreviatedTo complex-glycan-deficient,cgl
AE1_22061999_2_0 SS1_22061999_2_0 SS2_22061999_2_0 abbreviatedTo complex-glycan-deficient,cgl

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 21-26 http://edamontology.org/topic_2815 denotes human
T2 58-69 http://edamontology.org/topic_0786 denotes Arabidopsis
T3 110-116 http://edamontology.org/topic_0780 denotes plants
T4 173-180 http://edamontology.org/topic_0078 denotes protein
T5 212-223 http://edamontology.org/topic_0749 denotes termination
T6 309-314 http://edamontology.org/topic_2815 denotes human
T7 315-324 http://edamontology.org/topic_0616 denotes lysosomal
T8 404-415 http://edamontology.org/topic_0786 denotes Arabidopsis
T9 562-569 http://edamontology.org/topic_0634 denotes disease
T10 585-594 http://edamontology.org/topic_0616 denotes lysosomal
T11 603-610 http://edamontology.org/topic_0634 denotes disease
T12 649-658 http://edamontology.org/topic_0199 denotes mutations
T13 765-770 http://edamontology.org/topic_2815 denotes human
T14 1126-1131 http://edamontology.org/topic_2815 denotes human
T15 1204-1223 http://edamontology.org/topic_0081 denotes structural analyses
T16 1310-1320 http://edamontology.org/topic_0749 denotes terminated
T17 1381-1386 http://edamontology.org/topic_0780 denotes plant
T18 1440-1451 http://edamontology.org/topic_2830 denotes immunogenic
T19 1649-1660 http://edamontology.org/topic_0154 denotes amino acids
T20 1693-1700 http://edamontology.org/topic_0078 denotes protein
T21 1780-1787 http://edamontology.org/topic_0078 denotes protein
T22 1834-1839 http://edamontology.org/topic_0780 denotes plant

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 173-180 http://edamontology.org/data_1467 denotes protein
T2 173-180 http://edamontology.org/format_1208 denotes protein
T3 258-264 http://edamontology.org/data_2048 denotes report
T4 372-374 http://edamontology.org/data_1011 denotes EC
T5 539-541 http://edamontology.org/data_1011 denotes EC
T6 752-760 http://edamontology.org/operation_3429 denotes generate
T7 933-943 http://edamontology.org/data_2527 denotes parameters
T8 969-982 http://edamontology.org/data_2140 denotes concentration
T9 1204-1214 http://edamontology.org/data_0883 denotes structural
T10 1204-1223 http://edamontology.org/operation_2480 denotes structural analyses
T11 1693-1700 http://edamontology.org/format_1208 denotes protein
T12 1693-1700 http://edamontology.org/data_1467 denotes protein
T13 1780-1787 http://edamontology.org/format_1208 denotes protein
T14 1780-1787 http://edamontology.org/data_1467 denotes protein

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 867-875 http://purl.obolibrary.org/obo/MAT_0000348 denotes apoplast

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1637-1640 "http://rdf.glycoinfo.org/glycan/G02780QX" denotes non
GlycanIUPAC_T2 1637-1640 "http://rdf.glycoinfo.org/glycan/G18425DX" denotes non
GlycanIUPAC_T3 1637-1640 "http://rdf.glycoinfo.org/glycan/G18630JE" denotes non
GlycanIUPAC_T4 1637-1640 "http://rdf.glycoinfo.org/glycan/G01004IT" denotes non
GlycanIUPAC_T5 1637-1640 "http://rdf.glycoinfo.org/glycan/G87301QZ" denotes non
GlycanIUPAC_T6 1637-1640 "http://rdf.glycoinfo.org/glycan/G39790GW" denotes non
GlycanIUPAC_T7 1637-1640 "http://rdf.glycoinfo.org/glycan/G42928BB" denotes non
GlycanIUPAC_T8 1637-1640 "http://rdf.glycoinfo.org/glycan/G51134HC" denotes non
GlycanIUPAC_T9 1637-1640 "http://rdf.glycoinfo.org/glycan/G68183GR" denotes non
GlycanIUPAC_T10 1637-1640 "http://rdf.glycoinfo.org/glycan/G46883FA" denotes non
GlycanIUPAC_T11 1637-1640 "http://rdf.glycoinfo.org/glycan/G54702VY" denotes non

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants.
TextSentencer_T2 118-249 Sentence denotes There is a clear need for efficient methods to produce protein therapeutics requiring mannose-termination for therapeutic efficacy.
TextSentencer_T3 250-553 Sentence denotes Here we report on a unique system for production of active human lysosomal acid β-glucosidase (glucocerebrosidase, GCase, EC 3.2.1.45) using seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) mutant, which are deficient in the activity of N-acetylglucosaminyl transferase I (EC 2.4.1.101).
TextSentencer_T4 554-693 Sentence denotes Gaucher disease is a prevalent lysosomal storage disease in which affected individuals inherit mutations in the gene (GBA1) encoding GCase.
TextSentencer_T5 694-876 Sentence denotes A gene cassette optimized for seed expression was used to generate the human enzyme in seeds of the cgl (C5) mutant, and the recombinant GCase was mainly accumulated in the apoplast.
TextSentencer_T6 877-1194 Sentence denotes Importantly, the enzymatic properties including kinetic parameters, half-maximal inhibitory concentration of isofagomine and thermal stability of the cgl-derived GCase were comparable with those of imiglucerase, a commercially available recombinant human GCase used for enzyme replacement therapy in Gaucher patients.
TextSentencer_T7 1195-1321 Sentence denotes N-glycan structural analyses of recombinant cgl-GCase showed that the majority of the N-glycans (97%) were mannose terminated.
TextSentencer_T8 1322-1497 Sentence denotes Additional purification was required to remove ∼15% of the plant-derived recombinant GCase that possessed potentially immunogenic (xylose- and/or fucose-containing) N-glycans.
TextSentencer_T9 1498-1583 Sentence denotes Uptake of cgl-derived GCase by mouse macrophages was similar to that of imiglucerase.
TextSentencer_T10 1584-1788 Sentence denotes The cgl seed system requires no addition of foreign (non-native) amino acids to the mature recombinant GCase protein, and the dry transgenic seeds represent a stable repository of the therapeutic protein.
TextSentencer_T11 1789-1917 Sentence denotes Other strategies that may completely prevent plant-like complex N-glycans are discussed, including the use of a null cgl mutant.
T1 0-117 Sentence denotes Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants.
T2 118-249 Sentence denotes There is a clear need for efficient methods to produce protein therapeutics requiring mannose-termination for therapeutic efficacy.
T3 250-553 Sentence denotes Here we report on a unique system for production of active human lysosomal acid β-glucosidase (glucocerebrosidase, GCase, EC 3.2.1.45) using seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) mutant, which are deficient in the activity of N-acetylglucosaminyl transferase I (EC 2.4.1.101).
T4 554-693 Sentence denotes Gaucher disease is a prevalent lysosomal storage disease in which affected individuals inherit mutations in the gene (GBA1) encoding GCase.
T5 694-876 Sentence denotes A gene cassette optimized for seed expression was used to generate the human enzyme in seeds of the cgl (C5) mutant, and the recombinant GCase was mainly accumulated in the apoplast.
T6 877-1194 Sentence denotes Importantly, the enzymatic properties including kinetic parameters, half-maximal inhibitory concentration of isofagomine and thermal stability of the cgl-derived GCase were comparable with those of imiglucerase, a commercially available recombinant human GCase used for enzyme replacement therapy in Gaucher patients.
T7 1195-1321 Sentence denotes N-glycan structural analyses of recombinant cgl-GCase showed that the majority of the N-glycans (97%) were mannose terminated.
T8 1322-1497 Sentence denotes Additional purification was required to remove ∼15% of the plant-derived recombinant GCase that possessed potentially immunogenic (xylose- and/or fucose-containing) N-glycans.
T9 1498-1583 Sentence denotes Uptake of cgl-derived GCase by mouse macrophages was similar to that of imiglucerase.
T10 1584-1788 Sentence denotes The cgl seed system requires no addition of foreign (non-native) amino acids to the mature recombinant GCase protein, and the dry transgenic seeds represent a stable repository of the therapeutic protein.
T11 1789-1917 Sentence denotes Other strategies that may completely prevent plant-like complex N-glycans are discussed, including the use of a null cgl mutant.
T1 0-117 Sentence denotes Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants.
T2 118-249 Sentence denotes There is a clear need for efficient methods to produce protein therapeutics requiring mannose-termination for therapeutic efficacy.
T3 250-553 Sentence denotes Here we report on a unique system for production of active human lysosomal acid β-glucosidase (glucocerebrosidase, GCase, EC 3.2.1.45) using seeds of the Arabidopsis thaliana complex-glycan-deficient (cgl) mutant, which are deficient in the activity of N-acetylglucosaminyl transferase I (EC 2.4.1.101).
T4 554-693 Sentence denotes Gaucher disease is a prevalent lysosomal storage disease in which affected individuals inherit mutations in the gene (GBA1) encoding GCase.
T5 694-876 Sentence denotes A gene cassette optimized for seed expression was used to generate the human enzyme in seeds of the cgl (C5) mutant, and the recombinant GCase was mainly accumulated in the apoplast.
T6 877-1194 Sentence denotes Importantly, the enzymatic properties including kinetic parameters, half-maximal inhibitory concentration of isofagomine and thermal stability of the cgl-derived GCase were comparable with those of imiglucerase, a commercially available recombinant human GCase used for enzyme replacement therapy in Gaucher patients.
T7 1195-1321 Sentence denotes N-glycan structural analyses of recombinant cgl-GCase showed that the majority of the N-glycans (97%) were mannose terminated.
T8 1322-1497 Sentence denotes Additional purification was required to remove ∼15% of the plant-derived recombinant GCase that possessed potentially immunogenic (xylose- and/or fucose-containing) N-glycans.
T9 1498-1583 Sentence denotes Uptake of cgl-derived GCase by mouse macrophages was similar to that of imiglucerase.
T10 1584-1788 Sentence denotes The cgl seed system requires no addition of foreign (non-native) amino acids to the mature recombinant GCase protein, and the dry transgenic seeds represent a stable repository of the therapeutic protein.
T11 1789-1917 Sentence denotes Other strategies that may completely prevent plant-like complex N-glycans are discussed, including the use of a null cgl mutant.

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 1195-1203 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycan
T2 1281-1290 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans
T3 1487-1496 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans
T4 1853-1862 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 867-875 Body_part denotes apoplast http://purl.obolibrary.org/obo/MAT_0000348

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 554-569 Disease denotes Gaucher disease http://purl.obolibrary.org/obo/MONDO_0018150
T2 585-610 Disease denotes lysosomal storage disease http://purl.obolibrary.org/obo/MONDO_0002561

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 21-26 OrganismTaxon denotes human 9606
T2 58-78 OrganismTaxon denotes Arabidopsis thaliana 3702
T3 309-314 OrganismTaxon denotes human 9606
T4 404-424 OrganismTaxon denotes Arabidopsis thaliana 3702
T5 765-770 OrganismTaxon denotes human 9606
T6 1126-1131 OrganismTaxon denotes human 9606
T7 1529-1534 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1535-1546 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1535-1546 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394