PubMed:19048115 / 221-492 JSONTXT

{"project":"LitCoin-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":271},"obj":"Sentence"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-entities","denotations":[{"id":"5559","span":{"begin":13,"end":17},"obj":"GeneOrGeneProduct"},{"id":"5560","span":{"begin":41,"end":46},"obj":"GeneOrGeneProduct"},{"id":"5561","span":{"begin":54,"end":59},"obj":"GeneOrGeneProduct"},{"id":"5562","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5563","span":{"begin":160,"end":164},"obj":"DiseaseOrPhenotypicFeature"},{"id":"5564","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A9","pred":"db_id","subj":"5559","obj":"NCBIGene:7157"},{"id":"A10","pred":"db_id","subj":"5560","obj":"NCBIGene:672"},{"id":"A11","pred":"db_id","subj":"5561","obj":"NCBIGene:675"},{"id":"A12","pred":"db_id","subj":"5562","obj":"MESH:D009369"},{"id":"A13","pred":"db_id","subj":"5563","obj":"MESH:D010051"},{"id":"A14","pred":"db_id","subj":"5564","obj":"MESH:D009369"}],"namespaces":[{"prefix":"_base","uri":"https://w3id.org/biolink/vocab/"},{"prefix":"MESH","uri":"http://id.nlm.nih.gov/mesh/"},{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id="},{"prefix":"NCBIGene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"OMIM","uri":"https://www.omim.org/entry/"},{"prefix":"DBSNP","uri":"https://www.ncbi.nlm.nih.gov/snp/"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-GeneOrGeneProduct-v0","denotations":[{"id":"T8","span":{"begin":0,"end":9},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":13,"end":17},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":41,"end":46},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":54,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":66,"end":76},"obj":"GeneOrGeneProduct"},{"id":"T13","span":{"begin":77,"end":85},"obj":"GeneOrGeneProduct"},{"id":"T14","span":{"begin":142,"end":147},"obj":"GeneOrGeneProduct"},{"id":"T15","span":{"begin":160,"end":164},"obj":"GeneOrGeneProduct"},{"id":"T16","span":{"begin":187,"end":196},"obj":"GeneOrGeneProduct"},{"id":"T17","span":{"begin":200,"end":205},"obj":"GeneOrGeneProduct"},{"id":"T18","span":{"begin":229,"end":239},"obj":"GeneOrGeneProduct"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-GeneOrGeneProduct-v2","denotations":[{"id":"T6","span":{"begin":13,"end":17},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":41,"end":46},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":54,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T9","span":{"begin":66,"end":76},"obj":"GeneOrGeneProduct"},{"id":"T10","span":{"begin":142,"end":147},"obj":"GeneOrGeneProduct"},{"id":"T11","span":{"begin":200,"end":205},"obj":"GeneOrGeneProduct"},{"id":"T12","span":{"begin":229,"end":239},"obj":"GeneOrGeneProduct"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-Disease-MeSH","denotations":[{"id":"T4","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A4","pred":"originalLabel","subj":"T4","obj":"D009369"},{"id":"A5","pred":"originalLabel","subj":"T5","obj":"D009369"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-GeneOrGeneProduct-v3","denotations":[{"id":"T5","span":{"begin":13,"end":17},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":54,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":66,"end":85},"obj":"GeneOrGeneProduct"},{"id":"T8","span":{"begin":229,"end":239},"obj":"GeneOrGeneProduct"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin_Mondo_095","denotations":[{"id":"T6","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005070"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005070"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-MeSH-Disease-2","denotations":[{"id":"T5","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":160,"end":164},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"ID:","subj":"T5","obj":"D009369"},{"id":"A6","pred":"ID:","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"ID:","subj":"T7","obj":"D009369"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-MONDO_bioort2019","denotations":[{"id":"T5","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T6","span":{"begin":160,"end":164},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A5","pred":"#label","subj":"T5","obj":"D009369"},{"id":"A6","pred":"#label","subj":"T6","obj":"DISEASE"},{"id":"A7","pred":"#label","subj":"T7","obj":"D009369"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"LitCoin-training-merged","denotations":[{"id":"T8","span":{"begin":229,"end":239},"obj":"GeneOrGeneProduct"},{"id":"T7","span":{"begin":66,"end":85},"obj":"GeneOrGeneProduct"},{"id":"T6","span":{"begin":54,"end":59},"obj":"GeneOrGeneProduct"},{"id":"T5","span":{"begin":13,"end":17},"obj":"GeneOrGeneProduct"},{"id":"T58509","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T32450","span":{"begin":160,"end":164},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T39735","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A7","pred":"#label","subj":"T58509","obj":"D009369"},{"id":"A6","pred":"#label","subj":"T32450","obj":"DISEASE"},{"id":"A5","pred":"#label","subj":"T39735","obj":"D009369"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"PMID_GLOBAL","denotations":[{"id":"T6","span":{"begin":60,"end":65},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":223,"end":228},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A6","pred":"mondo_id","subj":"T6","obj":"0005070"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0005070"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"19048115-2#13#17#gene7157","span":{"begin":13,"end":17},"obj":"gene7157"},{"id":"19048115-2#41#46#gene672","span":{"begin":41,"end":46},"obj":"gene672"},{"id":"19048115-2#22#33#diseaseC3887505","span":{"begin":22,"end":33},"obj":"diseaseC3887505"},{"id":"19048115-2#160#163#diseaseC1335177","span":{"begin":160,"end":163},"obj":"diseaseC1335177"},{"id":"19048115-2#22#33#diseaseC3887505","span":{"begin":22,"end":33},"obj":"diseaseC3887505"},{"id":"19048115-2#160#163#diseaseC1335177","span":{"begin":160,"end":163},"obj":"diseaseC1335177"}],"relations":[{"id":"13#17#gene715722#33#diseaseC3887505","pred":"associated_with","subj":"19048115-2#13#17#gene7157","obj":"19048115-2#22#33#diseaseC3887505"},{"id":"13#17#gene7157160#163#diseaseC1335177","pred":"associated_with","subj":"19048115-2#13#17#gene7157","obj":"19048115-2#160#163#diseaseC1335177"},{"id":"13#17#gene715722#33#diseaseC3887505","pred":"associated_with","subj":"19048115-2#13#17#gene7157","obj":"19048115-2#22#33#diseaseC3887505"},{"id":"13#17#gene7157160#163#diseaseC1335177","pred":"associated_with","subj":"19048115-2#13#17#gene7157","obj":"19048115-2#160#163#diseaseC1335177"},{"id":"41#46#gene67222#33#diseaseC3887505","pred":"associated_with","subj":"19048115-2#41#46#gene672","obj":"19048115-2#22#33#diseaseC3887505"},{"id":"41#46#gene672160#163#diseaseC1335177","pred":"associated_with","subj":"19048115-2#41#46#gene672","obj":"19048115-2#160#163#diseaseC1335177"},{"id":"41#46#gene67222#33#diseaseC3887505","pred":"associated_with","subj":"19048115-2#41#46#gene672","obj":"19048115-2#22#33#diseaseC3887505"},{"id":"41#46#gene672160#163#diseaseC1335177","pred":"associated_with","subj":"19048115-2#41#46#gene672","obj":"19048115-2#160#163#diseaseC1335177"}],"text":"Mutations of TP53 and dysfunction of the Brca1 and/or Brca2 tumor-suppressor proteins have been implicated in the molecular pathogenesis of a large fraction of OSCs, but frequent somatic mutations in other well-established tumor-suppressor genes have not been identified."}