PubMed:1769024 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":172,"end":262},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":263,"end":372},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":373,"end":531},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":532,"end":671},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":672,"end":782},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":171},"obj":"Sentence"},{"id":"T2","span":{"begin":172,"end":262},"obj":"Sentence"},{"id":"T3","span":{"begin":263,"end":372},"obj":"Sentence"},{"id":"T4","span":{"begin":373,"end":531},"obj":"Sentence"},{"id":"T5","span":{"begin":532,"end":671},"obj":"Sentence"},{"id":"T6","span":{"begin":672,"end":782},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Cross-linked, degradable starch microspheres as carriers of paramagnetic contrast agents for magnetic resonance imaging: synthesis, degradation, and relaxation properties.\nBiodegradable particles were produced by the cross-linking of starch with epichlorohydrin. Diethylenetriaminepenta-acetic acid (DTPA) was covalently linked to the particles by using DTPA bisanhydride. The small, gadolinium-labelled particles were 40-260% more efficient in vitro proton relaxation agents than the corresponding unbound chelate gadolinium-DTPA. The relaxation properties were dependent on the metal chelate, the particle size, the metal content, and the degree of substitution (d.s.). For the small gadolinium-DTPA particles, an increased d.s. decreased the rate of degradation by alpha-amylase."}