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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 185-190 OrganismTaxon denotes human NCBItxid:9606
T2 2103-2108 OrganismTaxon denotes human NCBItxid:9606
T3 2190-2195 OrganismTaxon denotes human NCBItxid:9606
T4 2799-2805 OrganismTaxon denotes humans NCBItxid:9605

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-72 Sentence denotes Photochemoprevention of ultraviolet B signaling and photocarcinogenesis.
T2 73-198 Sentence denotes Exposure to solar radiation, particularly its ultraviolet (UV) B component, has a variety of harmful effects on human health.
T3 199-354 Sentence denotes Some of these effects include sunburn cell formation, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression.
T4 355-449 Sentence denotes Amongst these various adverse effects of UV radiation, skin cancer is of the greatest concern.
T5 450-645 Sentence denotes Over the years, changes in lifestyle has led to a significant increase in the amount of UV radiation that people receive, and this consequently has led to a surge in the incidence of skin cancer.
T6 646-804 Sentence denotes The development of skin cancer is a complex multistage phenomenon involving three distinct stages exemplified by initiation, promotion and progression stages.
T7 805-910 Sentence denotes Each of these stages is mediated via alterations in various cellular, biochemical, and molecular changes.
T8 911-1115 Sentence denotes Initiation, the first step in the carcinogenesis process is essentially an irreversible step in which genetic alterations occur in genes that ultimately leads to DNA modification and fixation of mutation.
T9 1116-1344 Sentence denotes Tumor promotion is the essential process in cancer development involving clonal expansion of initiated cells giving rise to pre-malignant and then to malignant lesions, essentially by alterations in signal transduction pathways.
T10 1345-1486 Sentence denotes Tumor progression involves the conversion of pre-malignant and malignant lesions into an invasive and potentially metastatic malignant tumor.
T11 1487-1871 Sentence denotes All these processes for skin cancer development involve stimulation of DNA synthesis, DNA damage and proliferation, inflammation, immunosuppression, epidermal hyperplasia, cell cycle dysregulation, depletion of antioxidant defenses, impairment of signal transduction pathways, induction of cyclooxygenase, increase in prostaglandin synthesis, and induction of ornithine decarboxylase.
T12 1872-2200 Sentence denotes Photochemoprevention has been appreciated as a viable approach to reduce the occurrence of skin cancer and in recent years, the use of agents, especially botanical antioxidants, present in the common diet and beverages consumed by human population have gained considerable attention as photochemopreventive agents for human use.
T13 2201-2264 Sentence denotes Many such agents have also found a place in skin care products.
T14 2265-2378 Sentence denotes Although this is more common in oriental countries, its popularity is significantly growing in western countries.
T15 2379-2547 Sentence denotes In this article, we have summarized the available information of laboratory studies on UVB-mediated signaling that can be exploited as targets for photochemoprevention.
T16 2548-2806 Sentence denotes We suggest that the use of skin care products supplemented with proven chemopreventive agents in conjunction with the use of sunscreens along with educational efforts may be an effective strategy for reducing UV-induced photodamage and skin cancer in humans.
T17 2807-2871 Sentence denotes The mechanistic basis for the use of such products is discussed.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
1470 185-190 OrganismTaxon denotes human NCBITaxon:9606
1471 253-284 DiseaseOrPhenotypicFeature denotes basal and squamous cell cancers MESH:D002294|MESH:D018295
1472 286-294 DiseaseOrPhenotypicFeature denotes melanoma MESH:D008545
1473 296-305 DiseaseOrPhenotypicFeature denotes cataracts MESH:D002386
1474 410-421 DiseaseOrPhenotypicFeature denotes skin cancer MESH:D012878
1475 633-644 DiseaseOrPhenotypicFeature denotes skin cancer MESH:D012878
1476 665-676 DiseaseOrPhenotypicFeature denotes skin cancer MESH:D012878
1477 945-959 DiseaseOrPhenotypicFeature denotes carcinogenesis MESH:D009369
1478 1116-1121 DiseaseOrPhenotypicFeature denotes Tumor MESH:D009369
1479 1160-1166 DiseaseOrPhenotypicFeature denotes cancer MESH:D009369
1480 1345-1350 DiseaseOrPhenotypicFeature denotes Tumor MESH:D009369
1481 1480-1485 DiseaseOrPhenotypicFeature denotes tumor MESH:D009369
1482 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer MESH:D012878
1483 1603-1615 DiseaseOrPhenotypicFeature denotes inflammation MESH:D007249
1484 1636-1657 DiseaseOrPhenotypicFeature denotes epidermal hyperplasia MESH:D006965
1485 1698-1709 ChemicalEntity denotes antioxidant MESH:D000975
1486 1777-1791 GeneOrGeneProduct denotes cyclooxygenase NCBIGene:5742
1487 1805-1818 ChemicalEntity denotes prostaglandin MESH:D011453
1488 1847-1870 GeneOrGeneProduct denotes ornithine decarboxylase NCBIGene:4953
1489 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer MESH:D012878
1490 2036-2048 ChemicalEntity denotes antioxidants MESH:D000975
1491 2103-2108 OrganismTaxon denotes human NCBITaxon:9606
1492 2190-2195 OrganismTaxon denotes human NCBITaxon:9606
1493 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer MESH:D012878
1494 2799-2805 OrganismTaxon denotes humans NCBITaxon:9606

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 229-236 DiseaseOrPhenotypicFeature denotes sunburn 0005326
T2 277-284 DiseaseOrPhenotypicFeature denotes cancers 0004992
T3 286-294 DiseaseOrPhenotypicFeature denotes melanoma 0005105
T4 296-305 DiseaseOrPhenotypicFeature denotes cataracts 0005129
T5 335-353 DiseaseOrPhenotypicFeature denotes immune suppression 0007816
T6 410-421 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T7 415-421 DiseaseOrPhenotypicFeature denotes cancer 0004992
T8 633-644 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T9 638-644 DiseaseOrPhenotypicFeature denotes cancer 0004992
T10 665-676 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T11 670-676 DiseaseOrPhenotypicFeature denotes cancer 0004992
T12 1160-1166 DiseaseOrPhenotypicFeature denotes cancer 0004992
T13 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T14 1516-1522 DiseaseOrPhenotypicFeature denotes cancer 0004992
T15 1646-1657 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043
T16 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T17 1968-1974 DiseaseOrPhenotypicFeature denotes cancer 0004992
T18 2645-2656 DiseaseOrPhenotypicFeature denotes conjunction 0003799
T19 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T20 2789-2795 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 149-154 GeneOrGeneProduct denotes has a
T2 237-241 GeneOrGeneProduct denotes cell
T3 242-251 GeneOrGeneProduct denotes formation
T4 272-276 GeneOrGeneProduct denotes cell
T5 296-305 GeneOrGeneProduct denotes cataracts
T6 325-329 GeneOrGeneProduct denotes skin
T7 335-341 GeneOrGeneProduct denotes immune
T8 410-414 GeneOrGeneProduct denotes skin
T9 459-464 GeneOrGeneProduct denotes years
T10 607-612 GeneOrGeneProduct denotes surge
T11 633-637 GeneOrGeneProduct denotes skin
T12 665-669 GeneOrGeneProduct denotes skin
T13 759-769 GeneOrGeneProduct denotes initiation
T14 829-837 GeneOrGeneProduct denotes mediated
T15 911-921 GeneOrGeneProduct denotes Initiation
T16 933-937 GeneOrGeneProduct denotes step
T17 960-967 GeneOrGeneProduct denotes process
T18 999-1003 GeneOrGeneProduct denotes step
T19 1103-1114 GeneOrGeneProduct denotes of mutation
T20 1116-1121 GeneOrGeneProduct denotes Tumor
T21 1149-1159 GeneOrGeneProduct denotes process in
T22 1196-1205 GeneOrGeneProduct denotes expansion
T23 1209-1218 GeneOrGeneProduct denotes initiated
T24 1219-1224 GeneOrGeneProduct denotes cells
T25 1276-1283 GeneOrGeneProduct denotes lesions
T26 1315-1334 GeneOrGeneProduct denotes signal transduction
T27 1345-1350 GeneOrGeneProduct denotes Tumor
T28 1418-1425 GeneOrGeneProduct denotes lesions
T29 1480-1485 GeneOrGeneProduct denotes tumor
T30 1487-1490 GeneOrGeneProduct denotes All
T31 1497-1506 GeneOrGeneProduct denotes processes
T32 1511-1515 GeneOrGeneProduct denotes skin
T33 1577-1583 GeneOrGeneProduct denotes damage
T34 1659-1669 GeneOrGeneProduct denotes cell cycle
T35 1685-1694 GeneOrGeneProduct denotes depletion
T36 1710-1718 GeneOrGeneProduct denotes defenses
T39 1847-1870 GeneOrGeneProduct denotes ornithine decarboxylase
T37 1734-1753 GeneOrGeneProduct denotes signal transduction
T38 1777-1791 GeneOrGeneProduct denotes cyclooxygenase
T40 1938-1944 GeneOrGeneProduct denotes reduce
T41 1963-1967 GeneOrGeneProduct denotes skin
T42 1989-1994 GeneOrGeneProduct denotes years
T43 2201-2205 GeneOrGeneProduct denotes Many
T44 2245-2249 GeneOrGeneProduct denotes skin
T45 2250-2254 GeneOrGeneProduct denotes care
T46 2255-2263 GeneOrGeneProduct denotes products
T47 2349-2356 GeneOrGeneProduct denotes growing
T48 2419-2428 GeneOrGeneProduct denotes available
T49 2470-2478 GeneOrGeneProduct denotes mediated
T50 2575-2579 GeneOrGeneProduct denotes skin
T51 2580-2584 GeneOrGeneProduct denotes care
T52 2585-2593 GeneOrGeneProduct denotes products
T53 2748-2756 GeneOrGeneProduct denotes reducing
T54 2760-2767 GeneOrGeneProduct denotes induced
T55 2784-2788 GeneOrGeneProduct denotes skin
T56 2823-2828 GeneOrGeneProduct denotes basis
T57 2849-2857 GeneOrGeneProduct denotes products

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 237-241 GeneOrGeneProduct denotes cell
T2 272-276 GeneOrGeneProduct denotes cell
T3 933-937 GeneOrGeneProduct denotes step
T4 999-1003 GeneOrGeneProduct denotes step
T5 1196-1205 GeneOrGeneProduct denotes expansion
T6 1276-1283 GeneOrGeneProduct denotes lesions
T7 1315-1334 GeneOrGeneProduct denotes signal transduction
T8 1418-1425 GeneOrGeneProduct denotes lesions
T9 1659-1669 GeneOrGeneProduct denotes cell cycle
T10 1734-1753 GeneOrGeneProduct denotes signal transduction
T11 1777-1791 GeneOrGeneProduct denotes cyclooxygenase
T12 1847-1870 GeneOrGeneProduct denotes ornithine decarboxylase

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 229-236 DiseaseOrPhenotypicFeature denotes sunburn D013471
T2 263-284 DiseaseOrPhenotypicFeature denotes squamous cell cancers D018307
T3 286-294 DiseaseOrPhenotypicFeature denotes melanoma D008545
T4 296-305 DiseaseOrPhenotypicFeature denotes cataracts D002386
T5 410-421 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T6 633-644 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T7 665-676 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T8 945-959 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T9 1116-1121 DiseaseOrPhenotypicFeature denotes Tumor D009369
T10 1160-1166 DiseaseOrPhenotypicFeature denotes cancer D009369
T11 1244-1253 DiseaseOrPhenotypicFeature denotes malignant D009369
T12 1266-1275 DiseaseOrPhenotypicFeature denotes malignant D009369
T13 1345-1350 DiseaseOrPhenotypicFeature denotes Tumor D009369
T14 1394-1403 DiseaseOrPhenotypicFeature denotes malignant D009369
T15 1408-1417 DiseaseOrPhenotypicFeature denotes malignant D009369
T16 1470-1479 DiseaseOrPhenotypicFeature denotes malignant D009369
T17 1480-1485 DiseaseOrPhenotypicFeature denotes tumor D009369
T18 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T19 1603-1615 DiseaseOrPhenotypicFeature denotes inflammation D007249
T20 1646-1657 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T21 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T22 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer D012878

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 1196-1205 GeneOrGeneProduct denotes expansion
T2 1777-1791 GeneOrGeneProduct denotes cyclooxygenase
T3 1847-1870 GeneOrGeneProduct denotes ornithine decarboxylase

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 229-236 DiseaseOrPhenotypicFeature denotes sunburn 0005326
T2 263-284 DiseaseOrPhenotypicFeature denotes squamous cell cancers 0005096
T3 286-294 DiseaseOrPhenotypicFeature denotes melanoma 0005105
T4 325-329 DiseaseOrPhenotypicFeature denotes skin 0002531
T5 335-353 DiseaseOrPhenotypicFeature denotes immune suppression 0007816
T6 410-421 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T7 633-644 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T8 665-676 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T9 1470-1485 DiseaseOrPhenotypicFeature denotes malignant tumor 0004992
T10 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T11 1646-1657 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043
T12 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer 0002898
T13 2245-2249 DiseaseOrPhenotypicFeature denotes skin 0002531
T14 2494-2497 DiseaseOrPhenotypicFeature denotes can 0012833
T15 2575-2579 DiseaseOrPhenotypicFeature denotes skin 0002531
T16 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer 0002898

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 229-236 DiseaseOrPhenotypicFeature denotes sunburn D013471
T2 263-284 DiseaseOrPhenotypicFeature denotes squamous cell cancers D018307
T3 286-294 DiseaseOrPhenotypicFeature denotes melanoma D008545
T4 296-305 DiseaseOrPhenotypicFeature denotes cataracts D002386
T5 410-421 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T6 633-644 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T7 665-676 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T8 945-959 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T9 1116-1121 DiseaseOrPhenotypicFeature denotes Tumor D009369
T10 1160-1166 DiseaseOrPhenotypicFeature denotes cancer D009369
T11 1345-1350 DiseaseOrPhenotypicFeature denotes Tumor D009369
T12 1480-1485 DiseaseOrPhenotypicFeature denotes tumor D009369
T13 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T14 1603-1615 DiseaseOrPhenotypicFeature denotes inflammation DISEASE|D007249
T16 1646-1657 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T17 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T18 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer D012878

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 229-236 DiseaseOrPhenotypicFeature denotes sunburn D013471
T2 263-284 DiseaseOrPhenotypicFeature denotes squamous cell cancers D018307
T3 286-294 DiseaseOrPhenotypicFeature denotes melanoma D008545
T4 296-305 DiseaseOrPhenotypicFeature denotes cataracts D002386
T5 410-421 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T6 633-644 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T7 665-676 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T8 945-959 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T9 1116-1121 DiseaseOrPhenotypicFeature denotes Tumor D009369
T10 1160-1166 DiseaseOrPhenotypicFeature denotes cancer D009369
T11 1345-1350 DiseaseOrPhenotypicFeature denotes Tumor D009369
T12 1480-1485 DiseaseOrPhenotypicFeature denotes tumor D009369
T13 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T14 1603-1615 DiseaseOrPhenotypicFeature denotes inflammation D007249
T15 1646-1657 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T16 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T17 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer D012878

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 1698-1709 ChemicalEntity denotes antioxidant ChemicalEntity
T2 1777-1791 ChemicalEntity denotes cyclooxygenase D011451
T3 1805-1818 ChemicalEntity denotes prostaglandin D011453|http://purl.obolibrary.org/obo/CHEBI_26333
T5 1847-1870 ChemicalEntity denotes ornithine decarboxylase D009955
T6 2036-2048 ChemicalEntity denotes antioxidants ChemicalEntity

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 185-190 OrganismTaxon denotes human
T2 2103-2108 OrganismTaxon denotes human
T3 2190-2195 OrganismTaxon denotes human
T4 2799-2805 OrganismTaxon denotes humans

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T6 2036-2048 ChemicalEntity denotes antioxidants ChemicalEntity
T5 1847-1870 ChemicalEntity denotes ornithine decarboxylase D009955
T3 1805-1818 ChemicalEntity denotes prostaglandin http://purl.obolibrary.org/obo/CHEBI_26333|D011453
T2 1777-1791 ChemicalEntity denotes cyclooxygenase D011451
T1 1698-1709 ChemicalEntity denotes antioxidant ChemicalEntity
T1844 1847-1870 GeneOrGeneProduct denotes ornithine decarboxylase
T39222 1777-1791 GeneOrGeneProduct denotes cyclooxygenase
T17805 1196-1205 GeneOrGeneProduct denotes expansion
T17 2784-2795 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T16 1963-1974 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T15 1646-1657 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T14 1603-1615 DiseaseOrPhenotypicFeature denotes inflammation D007249
T13 1511-1522 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T12 1480-1485 DiseaseOrPhenotypicFeature denotes tumor D009369
T11 1345-1350 DiseaseOrPhenotypicFeature denotes Tumor D009369
T10 1160-1166 DiseaseOrPhenotypicFeature denotes cancer D009369
T9 1116-1121 DiseaseOrPhenotypicFeature denotes Tumor D009369
T8 945-959 DiseaseOrPhenotypicFeature denotes carcinogenesis D063646
T7 665-676 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T76527 633-644 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T92363 410-421 DiseaseOrPhenotypicFeature denotes skin cancer D012878
T4 296-305 DiseaseOrPhenotypicFeature denotes cataracts D002386
T2810 286-294 DiseaseOrPhenotypicFeature denotes melanoma D008545
T6160 263-284 DiseaseOrPhenotypicFeature denotes squamous cell cancers D018307
T38940 229-236 DiseaseOrPhenotypicFeature denotes sunburn D013471
T45977 2799-2805 OrganismTaxon denotes humans
T28629 2190-2195 OrganismTaxon denotes human
T91603 2103-2108 OrganismTaxon denotes human
T97927 185-190 OrganismTaxon denotes human

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-72 Sentence denotes Photochemoprevention of ultraviolet B signaling and photocarcinogenesis.
T2 73-198 Sentence denotes Exposure to solar radiation, particularly its ultraviolet (UV) B component, has a variety of harmful effects on human health.
T3 199-354 Sentence denotes Some of these effects include sunburn cell formation, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression.
T4 355-449 Sentence denotes Amongst these various adverse effects of UV radiation, skin cancer is of the greatest concern.
T5 450-645 Sentence denotes Over the years, changes in lifestyle has led to a significant increase in the amount of UV radiation that people receive, and this consequently has led to a surge in the incidence of skin cancer.
T6 646-804 Sentence denotes The development of skin cancer is a complex multistage phenomenon involving three distinct stages exemplified by initiation, promotion and progression stages.
T7 805-910 Sentence denotes Each of these stages is mediated via alterations in various cellular, biochemical, and molecular changes.
T8 911-1115 Sentence denotes Initiation, the first step in the carcinogenesis process is essentially an irreversible step in which genetic alterations occur in genes that ultimately leads to DNA modification and fixation of mutation.
T9 1116-1344 Sentence denotes Tumor promotion is the essential process in cancer development involving clonal expansion of initiated cells giving rise to pre-malignant and then to malignant lesions, essentially by alterations in signal transduction pathways.
T10 1345-1486 Sentence denotes Tumor progression involves the conversion of pre-malignant and malignant lesions into an invasive and potentially metastatic malignant tumor.
T11 1487-1871 Sentence denotes All these processes for skin cancer development involve stimulation of DNA synthesis, DNA damage and proliferation, inflammation, immunosuppression, epidermal hyperplasia, cell cycle dysregulation, depletion of antioxidant defenses, impairment of signal transduction pathways, induction of cyclooxygenase, increase in prostaglandin synthesis, and induction of ornithine decarboxylase.
T12 1872-2200 Sentence denotes Photochemoprevention has been appreciated as a viable approach to reduce the occurrence of skin cancer and in recent years, the use of agents, especially botanical antioxidants, present in the common diet and beverages consumed by human population have gained considerable attention as photochemopreventive agents for human use.
T13 2201-2264 Sentence denotes Many such agents have also found a place in skin care products.
T14 2265-2378 Sentence denotes Although this is more common in oriental countries, its popularity is significantly growing in western countries.
T15 2379-2547 Sentence denotes In this article, we have summarized the available information of laboratory studies on UVB-mediated signaling that can be exploited as targets for photochemoprevention.
T16 2548-2806 Sentence denotes We suggest that the use of skin care products supplemented with proven chemopreventive agents in conjunction with the use of sunscreens along with educational efforts may be an effective strategy for reducing UV-induced photodamage and skin cancer in humans.
T17 2807-2871 Sentence denotes The mechanistic basis for the use of such products is discussed.
T1 0-72 Sentence denotes Photochemoprevention of ultraviolet B signaling and photocarcinogenesis.
T2 73-198 Sentence denotes Exposure to solar radiation, particularly its ultraviolet (UV) B component, has a variety of harmful effects on human health.
T3 199-354 Sentence denotes Some of these effects include sunburn cell formation, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression.
T4 355-449 Sentence denotes Amongst these various adverse effects of UV radiation, skin cancer is of the greatest concern.
T5 450-645 Sentence denotes Over the years, changes in lifestyle has led to a significant increase in the amount of UV radiation that people receive, and this consequently has led to a surge in the incidence of skin cancer.
T6 646-804 Sentence denotes The development of skin cancer is a complex multistage phenomenon involving three distinct stages exemplified by initiation, promotion and progression stages.
T7 805-910 Sentence denotes Each of these stages is mediated via alterations in various cellular, biochemical, and molecular changes.
T8 911-1115 Sentence denotes Initiation, the first step in the carcinogenesis process is essentially an irreversible step in which genetic alterations occur in genes that ultimately leads to DNA modification and fixation of mutation.
T9 1116-1344 Sentence denotes Tumor promotion is the essential process in cancer development involving clonal expansion of initiated cells giving rise to pre-malignant and then to malignant lesions, essentially by alterations in signal transduction pathways.
T10 1345-1486 Sentence denotes Tumor progression involves the conversion of pre-malignant and malignant lesions into an invasive and potentially metastatic malignant tumor.
T11 1487-1871 Sentence denotes All these processes for skin cancer development involve stimulation of DNA synthesis, DNA damage and proliferation, inflammation, immunosuppression, epidermal hyperplasia, cell cycle dysregulation, depletion of antioxidant defenses, impairment of signal transduction pathways, induction of cyclooxygenase, increase in prostaglandin synthesis, and induction of ornithine decarboxylase.
T12 1872-2200 Sentence denotes Photochemoprevention has been appreciated as a viable approach to reduce the occurrence of skin cancer and in recent years, the use of agents, especially botanical antioxidants, present in the common diet and beverages consumed by human population have gained considerable attention as photochemopreventive agents for human use.
T13 2201-2264 Sentence denotes Many such agents have also found a place in skin care products.
T14 2265-2378 Sentence denotes Although this is more common in oriental countries, its popularity is significantly growing in western countries.
T15 2379-2547 Sentence denotes In this article, we have summarized the available information of laboratory studies on UVB-mediated signaling that can be exploited as targets for photochemoprevention.
T16 2548-2806 Sentence denotes We suggest that the use of skin care products supplemented with proven chemopreventive agents in conjunction with the use of sunscreens along with educational efforts may be an effective strategy for reducing UV-induced photodamage and skin cancer in humans.
T17 2807-2871 Sentence denotes The mechanistic basis for the use of such products is discussed.