PubMed:15126619 JSONTXT

{"project":"bionlp-st-pc-2013-training","denotations":[{"id":"T1","span":{"begin":24,"end":27},"obj":"Gene_or_gene_product"},{"id":"T2","span":{"begin":53,"end":56},"obj":"Gene_or_gene_product"},{"id":"T3","span":{"begin":144,"end":147},"obj":"Gene_or_gene_product"},{"id":"T4","span":{"begin":310,"end":319},"obj":"Cellular_component"},{"id":"T5","span":{"begin":361,"end":363},"obj":"Gene_or_gene_product"},{"id":"T6","span":{"begin":364,"end":367},"obj":"Gene_or_gene_product"},{"id":"T7","span":{"begin":393,"end":400},"obj":"Gene_or_gene_product"},{"id":"T8","span":{"begin":440,"end":443},"obj":"Gene_or_gene_product"},{"id":"T9","span":{"begin":469,"end":472},"obj":"Gene_or_gene_product"},{"id":"T10","span":{"begin":603,"end":606},"obj":"Gene_or_gene_product"},{"id":"T11","span":{"begin":625,"end":628},"obj":"Gene_or_gene_product"},{"id":"T12","span":{"begin":629,"end":632},"obj":"Gene_or_gene_product"}],"text":"Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.\nAlterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle."}