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PubMed:14597618 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway.
T2 131-239 Sentence denotes Insulin-like growth factor 1 (IGF1) was considered a potential candidate for the treatment of heart failure.
T3 240-354 Sentence denotes However, some animal studies and clinical trials have questioned whether elevating IGF1 chronically is beneficial.
T4 355-459 Sentence denotes Secondary effects of increased serum IGF1 levels on other tissues may explain these unfavorable results.
T5 460-693 Sentence denotes The aim of the current study was to examine the role of IGF1 in cardiac myocytes in the absence of secondary effects, and to elucidate downstream signaling pathways and transcriptional regulatory effects of the IGF1 receptor (IGF1R).
T6 694-872 Sentence denotes Transgenic mice overexpressing IGF1R in the heart displayed cardiac hypertrophy, which was the result of an increase in myocyte size, and there was no evidence of histopathology.
T7 873-1000 Sentence denotes IGF1R transgenics also displayed enhanced systolic function at 3 months of age, and this was maintained at 12-16 months of age.
T8 1001-1119 Sentence denotes The phosphoinositide 3-kinase (PI3K)-Akt-p70S6K1 pathway was significantly activated in hearts from IGF1R transgenics.
T9 1120-1341 Sentence denotes Cardiac hypertrophy induced by overexpression of IGF1R was completely blocked by a dominant negative PI3K(p110alpha) mutant, suggesting IGF1R promotes compensated cardiac hypertrophy in a PI3K(p110alpha)-dependent manner.
T10 1342-1496 Sentence denotes This study suggests that targeting the cardiac IGF1R-PI3K(p110alpha) pathway could be a potential therapeutic strategy for the treatment of heart failure.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 64-69 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T2 225-230 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T3 738-743 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T4 1089-1095 http://purl.obolibrary.org/obo/MAT_0000036 denotes hearts
T5 1482-1487 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 225-238 HP_0001635 denotes heart failure
T2 376-396 HP_0030269 denotes increased serum IGF1
T3 1482-1495 HP_0001635 denotes heart failure

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
14597618-1#0#28#gene3479 131-159 gene3479 denotes Insulin-like growth factor 1
14597618-1#30#34#gene3479 161-165 gene3479 denotes IGF1
14597618-1#94#107#diseaseC0018801 225-238 diseaseC0018801 denotes heart failure
14597618-1#94#107#diseaseC0018802 225-238 diseaseC0018802 denotes heart failure
14597618-1#94#107#diseaseC0018801 225-238 diseaseC0018801 denotes heart failure
14597618-1#94#107#diseaseC0018802 225-238 diseaseC0018802 denotes heart failure
14597618-9#53#57#gene5290 1395-1399 gene5290 denotes PI3K
14597618-9#53#57#gene5291 1395-1399 gene5291 denotes PI3K
14597618-9#53#57#gene5293 1395-1399 gene5293 denotes PI3K
14597618-9#53#57#gene5294 1395-1399 gene5294 denotes PI3K
14597618-9#58#67#gene5290 1400-1409 gene5290 denotes p110alpha
14597618-9#140#153#diseaseC0018801 1482-1495 diseaseC0018801 denotes heart failure
14597618-9#140#153#diseaseC0018802 1482-1495 diseaseC0018802 denotes heart failure
14597618-9#140#153#diseaseC0018801 1482-1495 diseaseC0018801 denotes heart failure
14597618-9#140#153#diseaseC0018802 1482-1495 diseaseC0018802 denotes heart failure
14597618-9#140#153#diseaseC0018801 1482-1495 diseaseC0018801 denotes heart failure
14597618-9#140#153#diseaseC0018802 1482-1495 diseaseC0018802 denotes heart failure
14597618-9#140#153#diseaseC0018801 1482-1495 diseaseC0018801 denotes heart failure
14597618-9#140#153#diseaseC0018802 1482-1495 diseaseC0018802 denotes heart failure
14597618-9#140#153#diseaseC0018801 1482-1495 diseaseC0018801 denotes heart failure
14597618-9#140#153#diseaseC0018802 1482-1495 diseaseC0018802 denotes heart failure
0#28#gene347994#107#diseaseC0018801 14597618-1#0#28#gene3479 14597618-1#94#107#diseaseC0018801 associated_with Insulin-like growth factor 1,heart failure
0#28#gene347994#107#diseaseC0018802 14597618-1#0#28#gene3479 14597618-1#94#107#diseaseC0018802 associated_with Insulin-like growth factor 1,heart failure
0#28#gene347994#107#diseaseC0018801 14597618-1#0#28#gene3479 14597618-1#94#107#diseaseC0018801 associated_with Insulin-like growth factor 1,heart failure
0#28#gene347994#107#diseaseC0018802 14597618-1#0#28#gene3479 14597618-1#94#107#diseaseC0018802 associated_with Insulin-like growth factor 1,heart failure
30#34#gene347994#107#diseaseC0018801 14597618-1#30#34#gene3479 14597618-1#94#107#diseaseC0018801 associated_with IGF1,heart failure
30#34#gene347994#107#diseaseC0018802 14597618-1#30#34#gene3479 14597618-1#94#107#diseaseC0018802 associated_with IGF1,heart failure
30#34#gene347994#107#diseaseC0018801 14597618-1#30#34#gene3479 14597618-1#94#107#diseaseC0018801 associated_with IGF1,heart failure
30#34#gene347994#107#diseaseC0018802 14597618-1#30#34#gene3479 14597618-1#94#107#diseaseC0018802 associated_with IGF1,heart failure
53#57#gene5290140#153#diseaseC0018801 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018802 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018801 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018802 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018801 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018802 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018801 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018802 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018801 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5290140#153#diseaseC0018802 14597618-9#53#57#gene5290 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018801 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018802 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018801 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018802 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018801 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018802 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018801 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018802 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018801 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5291140#153#diseaseC0018802 14597618-9#53#57#gene5291 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018801 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018802 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018801 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018802 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018801 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018802 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018801 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018802 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018801 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5293140#153#diseaseC0018802 14597618-9#53#57#gene5293 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018801 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018802 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018801 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018802 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018801 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018802 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018801 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018802 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018801 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018801 associated_with PI3K,heart failure
53#57#gene5294140#153#diseaseC0018802 14597618-9#53#57#gene5294 14597618-9#140#153#diseaseC0018802 associated_with PI3K,heart failure
58#67#gene5290140#153#diseaseC0018801 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018801 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018802 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018802 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018801 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018801 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018802 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018802 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018801 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018801 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018802 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018802 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018801 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018801 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018802 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018802 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018801 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018801 associated_with p110alpha,heart failure
58#67#gene5290140#153#diseaseC0018802 14597618-9#58#67#gene5290 14597618-9#140#153#diseaseC0018802 associated_with p110alpha,heart failure

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20038198 1120-1340 kin(p(MGI:Igf1r)) increases kin(p(MGI:Pik3ca)) denotes Cardiac hypertrophy induced by overexpression of IGF1R was completely blocked by a dominant negative PI3K(p110alpha) mutant, suggesting IGF1R promotes compensated cardiac hypertrophy in a PI3K(p110alpha)-dependent manner

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1389-1394 gene:3480 denotes IGF1R
T1 1482-1495 disease:C0018801 denotes heart failure
T2 1389-1394 gene:3480 denotes IGF1R
T3 1482-1495 disease:C0018802 denotes heart failure
T4 1395-1399 gene:5294 denotes PI3K
T5 1482-1495 disease:C0018801 denotes heart failure
T6 1395-1399 gene:5294 denotes PI3K
T7 1482-1495 disease:C0018802 denotes heart failure
T8 1395-1399 gene:5293 denotes PI3K
T9 1482-1495 disease:C0018801 denotes heart failure
T10 1395-1399 gene:5293 denotes PI3K
T11 1482-1495 disease:C0018802 denotes heart failure
T12 1395-1399 gene:5290 denotes PI3K
T13 1482-1495 disease:C0018801 denotes heart failure
T14 1395-1399 gene:5290 denotes PI3K
T15 1482-1495 disease:C0018802 denotes heart failure
T16 1395-1399 gene:5291 denotes PI3K
T17 1482-1495 disease:C0018801 denotes heart failure
T18 1395-1399 gene:5291 denotes PI3K
T19 1482-1495 disease:C0018802 denotes heart failure
T20 1400-1409 gene:5290 denotes p110alpha
T21 1482-1495 disease:C0018801 denotes heart failure
T22 1400-1409 gene:5290 denotes p110alpha
T23 1482-1495 disease:C0018802 denotes heart failure
R1 T0 T1 associated_with IGF1R,heart failure
R2 T2 T3 associated_with IGF1R,heart failure
R3 T4 T5 associated_with PI3K,heart failure
R4 T6 T7 associated_with PI3K,heart failure
R5 T8 T9 associated_with PI3K,heart failure
R6 T10 T11 associated_with PI3K,heart failure
R7 T12 T13 associated_with PI3K,heart failure
R8 T14 T15 associated_with PI3K,heart failure
R9 T16 T17 associated_with PI3K,heart failure
R10 T18 T19 associated_with PI3K,heart failure
R11 T20 T21 associated_with p110alpha,heart failure
R12 T22 T23 associated_with p110alpha,heart failure

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 64-69 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T2 225-230 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T3 738-743 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036
T4 1089-1095 Body_part denotes hearts http://purl.obolibrary.org/obo/MAT_0000036
T5 1482-1487 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 225-238 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T2 1482-1495 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 705-709 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 64-69 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T5 225-230 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T9 524-540 Body_part denotes cardiac myocytes http://purl.obolibrary.org/obo/CL_0000746
T10 738-743 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230
T14 814-821 Body_part denotes myocyte http://purl.obolibrary.org/obo/CL_0000187
T15 1482-1487 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230