PubMed:11784720 / 202-471 JSONTXT

{"project":"sentences","denotations":[{"id":"T3","span":{"begin":0,"end":269},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":120,"end":126},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"T2","span":{"begin":134,"end":140},"obj":"http://purl.obolibrary.org/obo/MAT_0000098"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"FSU-PRGE","denotations":[{"id":"T7","span":{"begin":25,"end":28},"obj":"protein"},{"id":"T8","span":{"begin":43,"end":46},"obj":"protein"},{"id":"T9","span":{"begin":71,"end":79},"obj":"protein"},{"id":"T10","span":{"begin":80,"end":87},"obj":"protein"},{"id":"T11","span":{"begin":89,"end":92},"obj":"protein"},{"id":"T12","span":{"begin":179,"end":182},"obj":"protein"},{"id":"T13","span":{"begin":195,"end":199},"obj":"protein"},{"id":"T14","span":{"begin":264,"end":268},"obj":"protein"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"PIR-corpus2","denotations":[{"id":"T7","span":{"begin":25,"end":28},"obj":"protein"},{"id":"T8","span":{"begin":43,"end":46},"obj":"protein"},{"id":"T9","span":{"begin":54,"end":87},"obj":"protein"},{"id":"T10","span":{"begin":89,"end":92},"obj":"protein"},{"id":"T11","span":{"begin":179,"end":182},"obj":"protein"},{"id":"T12","span":{"begin":195,"end":199},"obj":"protein"},{"id":"T13","span":{"begin":264,"end":268},"obj":"protein"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"PIR-corpus1","denotations":[{"id":"T7","span":{"begin":25,"end":28},"obj":"protein"},{"id":"T8","span":{"begin":54,"end":79},"obj":"protein"},{"id":"T9","span":{"begin":80,"end":87},"obj":"protein"},{"id":"T10","span":{"begin":89,"end":92},"obj":"protein"},{"id":"T11","span":{"begin":195,"end":199},"obj":"protein"},{"id":"T12","span":{"begin":264,"end":268},"obj":"protein"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":120,"end":126},"obj":"Body_part"},{"id":"T2","span":{"begin":134,"end":140},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000098"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000098"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":158,"end":177},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0002511"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":5,"end":15},"obj":"Disease"},{"id":"T2","span":{"begin":158,"end":177},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005527"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0004975"}],"text":"Upon neurotoxic insults, p35 is cleaved to p25 by the Ca(2+)-dependent protease calpain. p25 is accumulated in ischemic brains and in brains of patients with Alzheimer's disease. p25 deregulates Cdk5 activity by causing prolonged activation and mislocalization of Cdk5."}