> top > docs > PubMed:11418678 > annotations

PubMed:11418678 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
T2 102-301 Sentence denotes Glycosylphosphatidylinositol (GPI) anchors and glycoinositolphospholipids (GIPLs) from parasitic protozoa have been shown to exert a wide variety of effects on cells of the host innate immune system.
T3 302-401 Sentence denotes However, the receptor(s) that are triggered by these protozoan glycolipids has not been identified.
T4 402-658 Sentence denotes Here we present evidence that Trypanosoma cruzi-derived GPI anchors and GIPLs trigger CD25 expression on Chinese hamster ovary-K1 cells transfected with CD14 and Toll-like receptor-2 (TLR-2), but not wild-type (TLR-2-deficient) Chinese hamster ovary cells.
T5 659-847 Sentence denotes The protozoan-derived GPI anchors and GIPLs containing alkylacylglycerol and saturated fatty acid chains or ceramide were found to be active in a concentration range of 100 nM to 1 microM.
T6 848-1093 Sentence denotes More importantly, the GPI anchors purified from T. cruzi trypomastigotes, which contain a longer glycan core and unsaturated fatty acids in the sn-2 position of the alkylacylglycerolipid component, triggered TLR-2 at subnanomolar concentrations.
T7 1094-1332 Sentence denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes.
T8 1333-1455 Sentence denotes Thus, highly purified GPI anchors from T. cruzi parasites are potent activators of TLR-2 from both mouse and human origin.
T9 1456-1661 Sentence denotes The activation of TLR-2 may initiate host innate defense mechanisms and inflammatory response during protozoan infection, and may provide new strategies for immune intervention during protozoan infections.
T1 0-101 Sentence denotes Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
T2 102-301 Sentence denotes Glycosylphosphatidylinositol (GPI) anchors and glycoinositolphospholipids (GIPLs) from parasitic protozoa have been shown to exert a wide variety of effects on cells of the host innate immune system.
T3 302-401 Sentence denotes However, the receptor(s) that are triggered by these protozoan glycolipids has not been identified.
T4 402-658 Sentence denotes Here we present evidence that Trypanosoma cruzi-derived GPI anchors and GIPLs trigger CD25 expression on Chinese hamster ovary-K1 cells transfected with CD14 and Toll-like receptor-2 (TLR-2), but not wild-type (TLR-2-deficient) Chinese hamster ovary cells.
T5 659-847 Sentence denotes The protozoan-derived GPI anchors and GIPLs containing alkylacylglycerol and saturated fatty acid chains or ceramide were found to be active in a concentration range of 100 nM to 1 microM.
T6 848-1093 Sentence denotes More importantly, the GPI anchors purified from T. cruzi trypomastigotes, which contain a longer glycan core and unsaturated fatty acids in the sn-2 position of the alkylacylglycerolipid component, triggered TLR-2 at subnanomolar concentrations.
T7 1094-1332 Sentence denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes.
T8 1333-1455 Sentence denotes Thus, highly purified GPI anchors from T. cruzi parasites are potent activators of TLR-2 from both mouse and human origin.
T9 1456-1661 Sentence denotes The activation of TLR-2 may initiate host innate defense mechanisms and inflammatory response during protozoan infection, and may provide new strategies for immune intervention during protozoan infections.

2015-BEL-Sample

Id Subject Object Predicate Lexical cue
T1 1094-1331 cat(p(MGI:Tlr2)) increases p(MGI:Il12a) denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20000336 1094-1331 cat(p(MGI:Tlr2)) increases p(MGI:Tnf) denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes
BEL:20000338 1094-1331 cat(p(MGI:Tlr2)) increases p(MGI:Il12b) denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes
BEL:20000340 1094-1331 cat(p(MGI:Tlr2)) increases p(MGI:Il12a) denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes
BEL:20000342 1094-1331 cat(p(MGI:Tlr2)) increases a(CHEBI:"nitric oxide") denotes We performed experiments with macrophages from TLR-2 knockout and TLR-4 knockout mice, and found that TLR-2 expression appears to be essential for induction of IL-12, TNF-alpha, and NO by GPI anchors derived from T. cruzi trypomastigotes