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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 44-48 protein denotes IL-2
T2 178-194 cell_type denotes human lymphocyte
T3 483-495 cell_type denotes human T cell
T4 578-585 protein denotes cyclins
T5 591-615 protein denotes cyclin-dependent kinases
T6 741-745 protein denotes IL-2
T7 749-778 protein denotes IL-2R alpha- and gamma-chains
T8 792-796 protein denotes IL-2
T9 911-915 protein denotes IL-2
T10 919-926 cell_type denotes T cells
T11 1072-1082 protein denotes NF-kappa B
T12 1087-1091 protein denotes AP-1
T13 1139-1149 protein denotes NF-kappa B
T14 1208-1223 protein denotes I kappa B-alpha
T15 1228-1242 protein denotes I kappa B-beta
T16 1322-1332 protein denotes NF-kappa B
T17 1354-1361 cell_type denotes T cells
T18 1389-1393 protein denotes CD40
T19 1411-1424 cell_type denotes B lymphocytes

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-3 cui:C0205314 denotes New
E2-ti-1 22-26 cui:C0013227 denotes drug
E3-ti-1 27-36 cui:C0768471 denotes PNU156804
E4-ti-1 44-48 cui:C0879590 denotes IL-2
E5-ti-1 59-72 cui:C0334094 denotes proliferation
E6-ti-1 77-87 cui:C0079904 denotes NF-kappa B
E7-ti-1 92-96 cui:C0002059 denotes AP-1
T1 22-36 ISA denotes drug PNU156804
E1-ab-1 142-146 cui:C0013227 denotes drug
E2-ab-1 147-165 cui:C0077826 denotes undecylprodigiosin
E3-ab-1 178-183 cui:C0020114 denotes human
E4-ab-1 184-208 cui:C0596873 denotes lymphocyte proliferation
T2 142-165 ISA denotes drug undecylprodigiosin
T3 171-177 AFFECTS denotes blocks
T4 178-208 PROCESS_OF denotes human lymphocyte proliferation
E1-ab-2 248-257 cui:C0441712 denotes mechanism
E2-ab-2 273-276 cui:C0205314 denotes new
E3-ab-2 277-285 cui:C0243071 denotes analogue
E4-ab-2 289-291 cui:C0077826 denotes UP
E5-ab-2 293-302 cui:C0768471 denotes PNU156804
E6-ab-2 318-322 cui:C0205172 denotes more
E7-ab-2 323-332 cui:C0309049 denotes favorable
E8-ab-2 333-341 cui:C0439167 denotes activity
E9-ab-2 355-357 cui:C0077826 denotes UP
E10-ab-2 361-365 cui:C0026809 denotes mice
T5 350-354 compared_with denotes than
T6 350-354 higher_than denotes than
T7 358-360 TREATS denotes in
T8 358-360 TREATS denotes in
E1-ab-3 396-406 cui:C0205460 denotes biological
E2-ab-3 407-413 cui:C1280500 denotes effect
E3-ab-3 417-426 cui:C0768471 denotes PNU156804
E4-ab-3 462-464 cui:C0077826 denotes UP
E5-ab-3 466-475 cui:C0768471 denotes PNU156804
E6-ab-3 483-488 cui:C0020114 denotes human
E7-ab-3 489-509 cui:C1155046 denotes T cell proliferation
E8-ab-3 513-516 cui:C0444598 denotes mid
E9-ab-3 517-521 cui:C0205087 denotes late
E10-ab-3 543-553 cui:C0007586 denotes cell cycle
E11-ab-3 554-562 cui:C0936012 denotes analysis
E12-ab-3 564-574 cui:C0185117 denotes expression
E13-ab-3 578-585 cui:C0079183 denotes cyclins
E14-ab-3 591-615 cui:C0243045 denotes cyclin-dependent kinases
E15-ab-3 620-634 cui:C0035335 denotes retinoblastoma
E16-ab-3 635-650 cui:C0031715 denotes phosphorylation
T9 407-413 INTERACTS_WITH denotes effect
T10 483-509 PROCESS_OF denotes human T cell proliferation
E1-ab-4 655-663 cui:C0442796 denotes addition
E2-ab-4 678-687 cui:C0768471 denotes PNU156804
E3-ab-4 693-696 cui:C1518422 denotes not
E4-ab-4 721-730 cui:C0857127 denotes induction
E5-ab-4 741-745 cui:C0879590 denotes IL-2
E6-ab-4 749-754 cui:C1101536 denotes IL-2R
E7-ab-4 755-760 cui:C0439095 denotes alpha
E8-ab-4 792-796 cui:C0879590 denotes IL-2
E9-ab-4 807-827 cui:C1155046 denotes T cell proliferation
T11 783-791 DISRUPTS denotes inhibits
E1-ab-5 850-857 cui:C0443302 denotes several
E2-ab-5 858-867 cui:C1521991 denotes molecular
E3-ab-5 911-915 cui:C0879590 denotes IL-2
E4-ab-5 919-926 cui:C0039194 denotes T cells
T12 916-918 LOCATION_OF denotes in
E1-ab-6 941-950 cui:C0768471 denotes PNU156804
E2-ab-6 956-959 cui:C1518422 denotes not
E3-ab-6 968-973 cui:C0079068 denotes c-myc
E4-ab-6 978-983 cui:C1153488 denotes bcl-2
E5-ab-6 984-988 cui:C0035696 denotes mRNA
E6-ab-6 989-998 cui:C0857127 denotes induction
T13 960-967 INHIBITS denotes inhibit
E1-ab-7 1019-1028 cui:C0768471 denotes PNU156804
E2-ab-7 1072-1082 cui:C0079904 denotes NF-kappa B
E3-ab-7 1087-1091 cui:C0002059 denotes AP-1
E4-ab-7 1092-1113 cui:C0040648 denotes transcription factors
E1-ab-8 1115-1124 cui:C0768471 denotes PNU156804
E2-ab-8 1139-1149 cui:C0079904 denotes NF-kappa B
E3-ab-8 1193-1204 cui:C0243125 denotes degradation
E4-ab-8 1210-1215 cui:C0439099 denotes kappa
E5-ab-8 1218-1223 cui:C0439095 denotes alpha
E6-ab-8 1230-1235 cui:C0439099 denotes kappa
E1-ab-9 1244-1253 cui:C0768471 denotes PNU156804
E2-ab-9 1283-1301 cui:C0037080 denotes signaling pathways
E1-ab-10 1311-1314 cui:C1518422 denotes not
E2-ab-10 1322-1332 cui:C0079904 denotes NF-kappa B
E3-ab-10 1347-1350 cui:C0048451 denotes PMA
E4-ab-10 1354-1361 cui:C0039194 denotes T cells
E5-ab-10 1389-1393 cui:C1367009 denotes CD40
E6-ab-10 1411-1424 cui:C0004561 denotes B lymphocytes
T14 1333-1343 STIMULATES denotes activation
T15 1351-1353 LOCATION_OF denotes in
T16 1408-1410 LOCATION_OF denotes in
E1-ab-11 1447-1458 cui:C0033259 denotes prodigiosin
E2-ab-11 1459-1465 cui:C0015576 denotes family
E3-ab-11 1469-1487 cui:C0021081 denotes immunosuppressants
E4-ab-11 1493-1496 cui:C0205314 denotes new
E5-ab-11 1497-1503 cui:C0015576 denotes family
E6-ab-11 1507-1516 cui:C0567416 denotes molecules
E7-ab-11 1529-1534 cui:C0679622 denotes novel
E8-ab-11 1535-1541 cui:C1521840 denotes target
E9-ab-11 1542-1553 cui:C0037791 denotes specificity
E10-ab-11 1608-1613 cui:C0013227 denotes drugs
E11-ab-11 1622-1635 cui:C0010592 denotes cyclosporin A
E12-ab-11 1637-1642 cui:C0729218 denotes FK506
E13-ab-11 1648-1657 cui:C0072980 denotes rapamycin
T17 1608-1635 ISA denotes drugs such as cyclosporin A
T18 1608-1635 ISA denotes drugs such as cyclosporin A
T19 1608-1635 ISA denotes drugs such as cyclosporin A
R1 E3-ti-1 T1 subjectOf PNU156804,drug PNU156804
R2 E2-ti-1 T1 objectOf drug,drug PNU156804
R3 E2-ab-1 T2 subjectOf undecylprodigiosin,drug undecylprodigiosin
R4 E1-ab-1 T2 objectOf drug,drug undecylprodigiosin
R5 E2-ab-1 T3 subjectOf undecylprodigiosin,blocks
R6 E4-ab-1 T3 objectOf lymphocyte proliferation,blocks
R7 E4-ab-1 T4 subjectOf lymphocyte proliferation,human lymphocyte proliferation
R8 E3-ab-1 T4 objectOf human,human lymphocyte proliferation
R9 E7-ab-2 T5 subjectOf favorable,than
R10 E9-ab-2 T5 objectOf UP,than
R11 E7-ab-2 T6 subjectOf favorable,than
R12 E9-ab-2 T6 objectOf UP,than
R13 E9-ab-2 T7 subjectOf UP,in
R14 E10-ab-2 T7 objectOf mice,in
R15 E7-ab-2 T8 subjectOf favorable,in
R16 E10-ab-2 T8 objectOf mice,in
R17 E5-ab-3 T9 subjectOf PNU156804,effect
R18 E3-ab-3 T9 objectOf PNU156804,effect
R19 E7-ab-3 T10 subjectOf T cell proliferation,human T cell proliferation
R20 E6-ab-3 T10 objectOf human,human T cell proliferation
R21 E5-ab-4 T11 subjectOf IL-2,inhibits
R22 E9-ab-4 T11 objectOf T cell proliferation,inhibits
R23 E4-ab-5 T12 subjectOf T cells,in
R24 E3-ab-5 T12 objectOf IL-2,in
R25 E1-ab-6 T13 subjectOf PNU156804,inhibit
R26 E3-ab-6 T13 objectOf c-myc,inhibit
R27 E3-ab-10 T14 subjectOf PMA,activation
R28 E2-ab-10 T14 objectOf NF-kappa B,activation
R29 E4-ab-10 T15 subjectOf T cells,in
R30 E3-ab-10 T15 objectOf PMA,in
R31 E6-ab-10 T16 subjectOf B lymphocytes,in
R32 E5-ab-10 T16 objectOf CD40,in
R33 E11-ab-11 T17 subjectOf cyclosporin A,drugs such as cyclosporin A
R34 E10-ab-11 T17 objectOf drugs,drugs such as cyclosporin A
R35 E13-ab-11 T18 subjectOf rapamycin,drugs such as cyclosporin A
R36 E10-ab-11 T18 objectOf drugs,drugs such as cyclosporin A
R37 E12-ab-11 T19 subjectOf FK506,drugs such as cyclosporin A
R38 E10-ab-11 T19 objectOf drugs,drugs such as cyclosporin A

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-108 Sentence denotes New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation.
S2 109-218 Sentence denotes We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro.
S3 219-366 Sentence denotes We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice.
S4 367-651 Sentence denotes We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation.
S5 652-828 Sentence denotes In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation.
S6 829-927 Sentence denotes We have investigated several molecular pathways that are known to be activated by IL-2 in T cells.
S7 928-999 Sentence denotes We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction.
S8 1000-1114 Sentence denotes On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors.
S9 1115-1243 Sentence denotes PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta.
S10 1244-1425 Sentence denotes PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes.
S11 1426-1658 Sentence denotes We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-36 NP denotes New immunosuppressive drug PNU156804
C2 77-107 NP denotes NF-kappa B and AP-1 activation
C3 138-170 NP denotes the drug undecylprodigiosin (UP)
C5 289-291 NP denotes UP
C4 271-291 NP denotes a new analogue of UP
C6 293-302 NP denotes PNU156804
C7 304-309 NP denotes which
C8 417-426 NP denotes PNU156804
C9 462-464 NP denotes UP
C10 466-475 NP denotes PNU156804
C11 678-687 NP denotes PNU156804
C12 741-745 NP denotes IL-2
C13 850-876 NP denotes several molecular pathways
C14 877-881 NP denotes that
C15 911-915 NP denotes IL-2
C16 919-926 NP denotes T cells
C17 941-950 NP denotes PNU156804
C18 1019-1028 NP denotes PNU156804
C19 1050-1113 NP denotes the activation of the NF-kappa B and AP-1 transcription factors
C20 1139-1160 NP denotes NF-kappa B activation
C21 1244-1260 NP denotes PNU156804 action
C22 1303-1305 NP denotes it
C23 1322-1343 NP denotes NF-kappa B activation
C24 1354-1361 NP denotes T cells
C25 1373-1377 NP denotes that
C26 1507-1516 NP denotes molecules
C27 1517-1521 NP denotes that
R1 C5 C3 coref-ident UP,the drug undecylprodigiosin (UP)
R2 C4 C1 coref-ident a new analogue of UP,New immunosuppressive drug PNU156804
R3 C6 C4 coref-appos PNU156804,a new analogue of UP
R4 C7 C4 coref-relat which,a new analogue of UP
R5 C8 C4 coref-ident PNU156804,a new analogue of UP
R6 C9 C5 coref-ident UP,UP
R7 C10 C8 coref-ident PNU156804,PNU156804
R8 C11 C10 coref-ident PNU156804,PNU156804
R9 C14 C13 coref-relat that,several molecular pathways
R10 C15 C12 coref-ident IL-2,IL-2
R11 C17 C11 coref-ident PNU156804,PNU156804
R12 C18 C17 coref-ident PNU156804,PNU156804
R13 C19 C2 coref-ident the activation of the NF-kappa B and AP-1 transcription factors,NF-kappa B and AP-1 activation
R14 C22 C21 coref-pron it,PNU156804 action
R15 C23 C20 coref-ident NF-kappa B activation,NF-kappa B activation
R16 C24 C16 coref-ident T cells,T cells
R17 C25 C23 coref-pron that,NF-kappa B activation
R18 C27 C26 coref-relat that,molecules

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-26 other_organic_compound denotes immunosuppressive drug
T2 27-36 other_organic_compound denotes PNU156804
T3 44-48 protein_molecule denotes IL-2
T4 147-165 other_organic_compound denotes undecylprodigiosin
T5 167-169 other_organic_compound denotes UP
T6 178-194 cell_type denotes human lymphocyte
T7 289-291 other_organic_compound denotes UP
T8 293-302 other_organic_compound denotes PNU156804
T9 333-349 other_name denotes activity profile
T10 355-357 other_organic_compound denotes UP
T11 361-365 multi_cell denotes mice
T12 417-426 other_organic_compound denotes PNU156804
T13 462-464 other_organic_compound denotes UP
T14 466-475 other_organic_compound denotes PNU156804
T15 483-495 cell_type denotes human T cell
T16 513-524 other_name denotes mid-late G1
T17 543-562 other_name denotes cell cycle analysis
T18 578-585 protein_family_or_group denotes cyclins
T19 591-615 protein_family_or_group denotes cyclin-dependent kinases
T20 620-650 other_name denotes retinoblastoma phosphorylation
T21 678-687 other_organic_compound denotes PNU156804
T22 741-745 protein_molecule denotes IL-2
T23 792-796 protein_molecule denotes IL-2
T24 858-876 other_name denotes molecular pathways
T25 911-915 protein_molecule denotes IL-2
T26 919-926 cell_type denotes T cells
T27 941-950 other_organic_compound denotes PNU156804
T28 1019-1028 other_organic_compound denotes PNU156804
T29 1072-1082 protein_complex denotes NF-kappa B
T30 1087-1091 protein_molecule denotes AP-1
T31 1115-1124 other_organic_compound denotes PNU156804
T32 1139-1149 protein_complex denotes NF-kappa B
T33 1208-1223 protein_molecule denotes I kappa B-alpha
T34 1228-1242 protein_molecule denotes I kappa B-beta
T35 1244-1253 other_organic_compound denotes PNU156804
T36 1283-1301 other_name denotes signaling pathways
T37 1322-1332 protein_complex denotes NF-kappa B
T38 1347-1350 other_organic_compound denotes PMA
T39 1354-1361 cell_type denotes T cells
T40 1389-1393 protein_molecule denotes CD40
T41 1411-1424 cell_type denotes B lymphocytes
T42 1447-1465 other_organic_compound denotes prodigiosin family
T43 1469-1487 other_name denotes immunosuppressants
T44 1590-1613 other_name denotes immunosuppressive drugs
T45 1622-1635 other_organic_compound denotes cyclosporin A
T46 1637-1642 other_organic_compound denotes FK506
T47 1648-1657 other_organic_compound denotes rapamycin

metamap-sample

Id Subject Object Predicate Lexical cue
T1 1088-1092 C0085828 denotes P-1
T2 93-97 C0085828 denotes P-1
T3 1323-1333 C0079904 denotes F-kappa B
T4 78-88 C0079904 denotes F-kappa B
T5 1367-1372 C2828370 denotes locks
T6 698-703 C2828370 denotes lock
T7 477-483 C2828370 denotes locks
T8 172-178 C2828370 denotes locks
T9 38-44 C2828370 denotes locks
T10 1245-1254 C0768471 denotes NU156804
T11 1116-1125 C0768471 denotes NU156804
T12 1020-1029 C0768471 denotes NU156804
T13 942-951 C0768471 denotes NU156804
T14 679-688 C0768471 denotes NU156804
T15 294-303 C0768471 denotes NU156804,
T16 28-37 C0768471 denotes NU156804
T17 60-73 C0334094 denotes roliferation
T18 1334-1344 C1879547 denotes ctivation
T19 899-908 C1879547 denotes ctivated
T20 98-108 C1879547 denotes ctivation.
T21 912-916 C0879590 denotes L-2
T22 45-49 C0879590 denotes L-2-
T23 798-807 C0851827 denotes ependent
T24 50-59 C0851827 denotes ependent
T25 5-27 C2359945 denotes mmunosuppressive drug
T26 1494-1497 C0205314 denotes ew
T27 1530-1535 C0205314 denotes ovel
T28 274-277 C0205314 denotes ew
T29 1-4 C0205314 denotes ew
T30 484-489 C0086418 denotes uman
T31 179-183 C0086418 denotes uman
T32 463-465 C0077826 denotes P:
T33 148-166 C0077826 denotes ndecylprodigiosin
T34 1355-1362 C0039194 denotes cells
T35 920-927 C0039194 denotes cells.
T36 1042-1050 C0018790 denotes nhibits
T37 961-968 C0018790 denotes nhibit
T38 784-792 C0018790 denotes nhibits
T39 592-616 C0243045 denotes yclin-dependent kinases
T40 362-366 C0026809 denotes ice.
T41 750-755 C1101536 denotes L-2R
T42 979-984 C0376515 denotes cl-2
T43 1430-1438 C0917903 denotes onclude
T44 1523-1527 C1547282 denotes how
T45 932-936 C1547282 denotes how
T46 669-673 C1547282 denotes how
T47 311-316 C1547282 denotes hows
T48 128-133 C1547282 denotes hown
T49 1412-1425 C0004561 denotes lymphocytes.
T50 1348-1351 C0039654 denotes MA
T51 1623-1636 C0010592 denotes yclosporin A,
T52 428-436 C0021135 denotes n vitro
T53 210-218 C0021135 denotes n vitro.
T54 621-635 C0080113 denotes etinoblastoma
T55 1470-1488 C0021081 denotes mmunosuppressants
T56 1448-1459 C0033259 denotes rodigiosin
T57 1312-1315 C1518422 denotes ot
T58 957-960 C1518422 denotes ot
T59 694-697 C1518422 denotes ot
T60 1638-1643 C0729218 denotes K506,
T61 1014-1018 C0018563 denotes and,
T62 1649-1658 C0072980 denotes apamycin.
T63 636-651 C0031715 denotes hosphorylation.
T64 555-563 C1524024 denotes nalysis,
T65 985-989 C0035696 denotes RNA
T66 579-586 C0079183 denotes yclins,
T67 1316-1322 C0001721 denotes ffect
T68 1379-1386 C0205263 denotes nduced
T69 990-999 C0205263 denotes nduction.
T70 722-731 C0205263 denotes nduction
T71 838-850 C1292732 denotes nvestigated
T72 232-244 C1292732 denotes nvestigated
T73 1093-1114 C0040648 denotes ranscription factors.
T74 544-554 C0007586 denotes ell cycle
T75 1137-1161 C1749855 denotes f NF-kappa B activation
T76 1194-1205 C0699900 denotes egradation
T77 656-664 C1883712 denotes ddition,
T78 887-892 C0205309 denotes nown
T79 969-973 C0086661 denotes -myc
T80 1229-1243 C1527364 denotes kappa B-beta.
T81 228-231 C1948052 denotes ow
T82 893-895 C1883351 denotes o
T83 750-755 C1334114 denotes L-2R
T84 185-209 C0596873 denotes ymphocyte proliferation
T85 859-877 C1704259 denotes olecular pathways
T86 1255-1261 C0441472 denotes ction
T87 773-779 C1524075 denotes hains
T88 756-761 C2003941 denotes lpha-
T89 1543-1554 C1511884 denotes pecificity
T90 1395-1408 C0332220 denotes ross-linking
T91 565-575 C0185117 denotes xpression
T92 408-414 C1280500 denotes ffect
T93 1265-1275 C0443288 denotes estricted
T94 397-407 C0205460 denotes iological
T95 1165-1171 C0678226 denotes ue to
T96 343-350 C2003903 denotes rofile
T97 767-772 C1552644 denotes amma-
T98 143-147 C1254351 denotes rug
T99 851-858 C0439064 denotes everal
T100 1536-1542 C1521840 denotes arget
T101 1508-1517 C0567416 denotes olecules
T102 334-342 C0205177 denotes ctivity
T103 324-333 C3640814 denotes avorable
T104 518-522 C0205087 denotes ate
T105 278-286 C0243071 denotes nalogue

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 620-634 HP_0009919 denotes retinoblastoma