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sentences

Id Subject Object Predicate Lexical cue
T1 0-91 Sentence denotes Modulation of E2F complexes during G0 to S phase transition in human primary B-lymphocytes.
T2 92-173 Sentence denotes The pocket protein-E2F complexes are convergence points for cell cycle signaling.
T3 174-341 Sentence denotes In the present report, we identified and monitored the pocket protein-E2F complexes in human primary B-lymphocytes after activation by phorbol 12-myristate 13-acetate.
T4 342-642 Sentence denotes Consistent with previous data from human and mouse fibroblasts and T-lymphocytes, E2F4 and DP1 form the predominant E2F heterodimers both in G0 and G1 phases of the human B-lymphocyte cell cycle, whereas E2F1 and -3 are first detected in late G1, and their expression levels increase towards S phase.
T5 643-764 Sentence denotes Intriguingly, the major E2F complex that we detected in quiescent human B-lymphocytes is consisted of pRB, E2F4, and DP1.
T6 765-919 Sentence denotes Though the levels of DP1 and -2 increase when cells progress from G0 to S, the proportion of DP1 to DP2 remains relatively constant during the cell cycle.
T7 920-1076 Sentence denotes We also observed an increase in electrophoretic mobility of the predominant E2F components, DP1 and E2F4, as B-lymphocytes progressed from G0 into early G1.
T8 1077-1260 Sentence denotes This increase in mobility was attributable to dephosphorylation, as lambda phosphatase treatment could convert the slower migrating forms into the corresponding faster mobility forms.
T9 1261-1379 Sentence denotes We further demonstrated that this change in phosphorylation status correlates with a decrease in DNA binding activity.
T10 1380-1746 Sentence denotes This modulation of DNA binding activity mediated through the dephosphorylation of DP1 and E2F4 could help to explain the lack of in vivo DNA footprinting in late G1 and S phases of gene promoters negatively regulated through E2F sites and suggests a novel mechanism for controlling E2F transcriptional activity during the transition from quiescence to proliferation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-27 protein denotes E2F complexes
T2 63-90 cell_type denotes human primary B-lymphocytes
T3 96-124 protein denotes pocket protein-E2F complexes
T4 229-257 protein denotes pocket protein-E2F complexes
T5 261-288 cell_type denotes human primary B-lymphocytes
T6 377-404 cell_type denotes human and mouse fibroblasts
T7 409-422 cell_type denotes T-lymphocytes
T8 424-428 protein denotes E2F4
T9 433-436 protein denotes DP1
T10 458-474 protein denotes E2F heterodimers
T11 546-557 protein denotes E2F1 and -3
T12 661-678 protein denotes major E2F complex
T13 699-728 cell_type denotes quiescent human B-lymphocytes
T14 745-748 protein denotes pRB
T15 750-754 protein denotes E2F4
T16 760-763 protein denotes DP1
T17 786-796 protein denotes DP1 and -2
T18 858-861 protein denotes DP1
T19 865-868 protein denotes DP2
T20 996-1010 protein denotes E2F components
T21 1012-1015 protein denotes DP1
T22 1020-1024 protein denotes E2F4
T23 1029-1042 cell_type denotes B-lymphocytes
T24 1192-1214 protein denotes slower migrating forms
T25 1224-1259 protein denotes corresponding faster mobility forms
T26 1462-1465 protein denotes DP1
T27 1470-1474 protein denotes E2F4
T28 1561-1575 DNA denotes gene promoters
T29 1605-1614 DNA denotes E2F sites
T30 1662-1665 protein denotes E2F

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-91 Sentence denotes Modulation of E2F complexes during G0 to S phase transition in human primary B-lymphocytes.
S2 92-173 Sentence denotes The pocket protein-E2F complexes are convergence points for cell cycle signaling.
S3 174-341 Sentence denotes In the present report, we identified and monitored the pocket protein-E2F complexes in human primary B-lymphocytes after activation by phorbol 12-myristate 13-acetate.
S4 342-642 Sentence denotes Consistent with previous data from human and mouse fibroblasts and T-lymphocytes, E2F4 and DP1 form the predominant E2F heterodimers both in G0 and G1 phases of the human B-lymphocyte cell cycle, whereas E2F1 and -3 are first detected in late G1, and their expression levels increase towards S phase.
S5 643-764 Sentence denotes Intriguingly, the major E2F complex that we detected in quiescent human B-lymphocytes is consisted of pRB, E2F4, and DP1.
S6 765-919 Sentence denotes Though the levels of DP1 and -2 increase when cells progress from G0 to S, the proportion of DP1 to DP2 remains relatively constant during the cell cycle.
S7 920-1076 Sentence denotes We also observed an increase in electrophoretic mobility of the predominant E2F components, DP1 and E2F4, as B-lymphocytes progressed from G0 into early G1.
S8 1077-1260 Sentence denotes This increase in mobility was attributable to dephosphorylation, as lambda phosphatase treatment could convert the slower migrating forms into the corresponding faster mobility forms.
S9 1261-1379 Sentence denotes We further demonstrated that this change in phosphorylation status correlates with a decrease in DNA binding activity.
S10 1380-1746 Sentence denotes This modulation of DNA binding activity mediated through the dephosphorylation of DP1 and E2F4 could help to explain the lack of in vivo DNA footprinting in late G1 and S phases of gene promoters negatively regulated through E2F sites and suggests a novel mechanism for controlling E2F transcriptional activity during the transition from quiescence to proliferation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-27 NP denotes E2F complexes
C2 63-90 NP denotes human primary B-lymphocytes
C3 92-124 NP denotes The pocket protein-E2F complexes
C4 261-288 NP denotes human primary B-lymphocytes
C5 424-428 NP denotes E2F4
C6 433-436 NP denotes DP1
C7 546-557 NP denotes E2F1 and -3
C8 593-598 NP denotes their
C9 657-678 NP denotes the major E2F complex
C10 679-683 NP denotes that
C11 750-754 NP denotes E2F4
C12 760-763 NP denotes DP1
C13 858-861 NP denotes DP1
C14 980-1010 NP denotes the predominant E2F components
C16 1012-1015 NP denotes DP1
C17 1020-1024 NP denotes E2F4
C15 1012-1024 NP denotes DP1 and E2F4
C18 1358-1378 NP denotes DNA binding activity
C19 1399-1419 NP denotes DNA binding activity
C21 1462-1465 NP denotes DP1
C22 1470-1474 NP denotes E2F4
C20 1462-1474 NP denotes DP1 and E2F4
R1 C3 C1 coref-ident The pocket protein-E2F complexes,E2F complexes
R2 C4 C2 coref-ident human primary B-lymphocytes,human primary B-lymphocytes
R3 C8 C7 coref-pron their,E2F1 and -3
R4 C10 C9 coref-relat that,the major E2F complex
R5 C11 C5 coref-ident E2F4,E2F4
R6 C12 C6 coref-ident DP1,DP1
R7 C13 C12 coref-ident DP1,DP1
R8 C16 C13 coref-ident DP1,DP1
R9 C17 C11 coref-ident E2F4,E2F4
R10 C15 C14 coref-appos DP1 and E2F4,the predominant E2F components
R11 C19 C18 coref-ident DNA binding activity,DNA binding activity
R12 C21 C16 coref-ident DP1,DP1
R13 C22 C17 coref-ident E2F4,E2F4
R14 C20 C14 coref-ident DP1 and E2F4,the predominant E2F components

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-27 protein_complex denotes E2F complexes
T2 35-59 other_name denotes G0 to S phase transition
T3 63-90 cell_type denotes human primary B-lymphocytes
T4 96-111 protein_complex denotes pocket protein-
T5 111-124 protein_complex denotes E2F complexes
T6 152-172 other_name denotes cell cycle signaling
T7 229-244 protein_complex denotes pocket protein-
T8 244-257 protein_complex denotes E2F complexes
T9 261-288 cell_type denotes human primary B-lymphocytes
T10 309-340 other_organic_compound denotes phorbol 12-myristate 13-acetate
T11 409-422 cell_type denotes T-lymphocytes
T12 424-428 protein_molecule denotes E2F4
T13 433-436 protein_molecule denotes DP1
T14 458-474 protein_complex denotes E2F heterodimers
T15 507-536 other_name denotes human B-lymphocyte cell cycle
T16 585-587 other_name denotes G1
T17 599-616 other_name denotes expression levels
T18 634-641 other_name denotes S phase
T19 661-678 protein_complex denotes major E2F complex
T20 699-728 cell_type denotes quiescent human B-lymphocytes
T21 745-748 protein_molecule denotes pRB
T22 750-754 protein_molecule denotes E2F4
T23 760-763 protein_molecule denotes DP1
T24 831-833 other_name denotes G0
T25 837-838 other_name denotes S
T26 858-861 protein_molecule denotes DP1
T27 865-868 protein_molecule denotes DP2
T28 996-1010 protein_family_or_group denotes E2F components
T29 1012-1015 protein_molecule denotes DP1
T30 1020-1024 protein_molecule denotes E2F4
T31 1029-1042 cell_type denotes B-lymphocytes
T32 1059-1061 other_name denotes G0
T33 1073-1075 other_name denotes G1
T34 1123-1140 other_name denotes dephosphorylation
T35 1192-1214 protein_family_or_group denotes slower migrating forms
T36 1224-1259 protein_family_or_group denotes corresponding faster mobility forms
T37 1305-1327 other_name denotes phosphorylation status
T38 1399-1419 other_name denotes DNA binding activity
T39 1441-1458 other_name denotes dephosphorylation
T40 1462-1465 protein_molecule denotes DP1
T41 1470-1474 protein_molecule denotes E2F4
T42 1509-1533 other_name denotes in vivo DNA footprinting
T43 1561-1575 DNA_family_or_group denotes gene promoters
T44 1605-1614 DNA_domain_or_region denotes E2F sites
T45 1662-1665 protein_molecule denotes E2F
T46 1718-1728 other_name denotes quiescence
T47 1732-1745 other_name denotes proliferation

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T2 261-266 OrganismTaxon denotes human 9606
T3 377-382 OrganismTaxon denotes human 9606
T4 387-392 OrganismTaxon denotes mouse 10088|10090
T6 507-512 OrganismTaxon denotes human 9606
T7 709-714 OrganismTaxon denotes human 9606
T1 63-68 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 77-90 Body_part denotes B-lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T2 152-162 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T3 275-288 Body_part denotes B-lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T4 393-404 Body_part denotes fibroblasts http://purl.obolibrary.org/obo/CL_0000057
T5 409-422 Body_part denotes T-lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T6 513-525 Body_part denotes B-lymphocyte http://purl.obolibrary.org/obo/CL_0000236
T7 526-536 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T8 715-728 Body_part denotes B-lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T9 908-918 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T10 1029-1042 Body_part denotes B-lymphocytes http://purl.obolibrary.org/obo/CL_0000236
T11 1145-1151 Body_part denotes lambda http://purl.obolibrary.org/obo/UBERON_0013424

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 77-90 Cell denotes B-lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T2 275-288 Cell denotes B-lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T3 393-404 Cell denotes fibroblasts http://purl.obolibrary.org/obo/CL:0000057
T4 409-422 Cell denotes T-lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T5 513-525 Cell denotes B-lymphocyte http://purl.obolibrary.org/obo/CL:0000236
T6 515-525 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T7 715-728 Cell denotes B-lymphocytes http://purl.obolibrary.org/obo/CL:0000236
T8 1029-1042 Cell denotes B-lymphocytes http://purl.obolibrary.org/obo/CL:0000236