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sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
T2 120-376 Sentence denotes Activation of T lymphocytes to produce cytokines is regulated by the counterbalance of protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high degree of substrate specificity because of physical association with their targets.
T3 377-632 Sentence denotes Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in suppression of T lymphocyte activation as measured by T cell antigen receptor-induced activation of transcription factors binding to the 5' promoter of the interleukin-2 gene.
T4 633-920 Sentence denotes Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein (MAP) kinases Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells.
T5 921-1023 Sentence denotes In contrast, HePTP had no effects on N-terminal c-Jun kinase or on events upstream of the MAP kinases.
T6 1024-1194 Sentence denotes The specificity of HePTP correlated with its physical association through its noncatalytic N terminus with Erk and another MAP kinase, p38, but not Jnk or other proteins.
T7 1195-1459 Sentence denotes We propose that HePTP plays a negative role in antigen receptor signaling by specifically regulating MAP kinases in the cytosol and at early time points of T cell activation before the activation-induced expression of nuclear dual-specific MAP kinase phosphatases.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 34-110 protein denotes mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase
T2 112-117 protein denotes HePTP
T3 134-147 cell_type denotes T lymphocytes
T4 159-168 protein denotes cytokines
T5 207-231 protein denotes protein-tyrosine kinases
T6 395-437 protein denotes hematopoietic protein-tyrosine phosphatase
T7 439-444 protein denotes HePTP
T8 511-534 protein denotes T cell antigen receptor
T9 557-578 protein denotes transcription factors
T10 594-605 DNA denotes 5' promoter
T11 613-631 DNA denotes interleukin-2 gene
T12 697-702 protein denotes HePTP
T13 742-747 protein denotes HePTP
T14 769-808 protein denotes mitogen-activated protein (MAP) kinases
T15 809-819 protein denotes Erk1 and 2
T16 905-919 cell_type denotes intact T cells
T17 934-939 protein denotes HePTP
T18 958-981 protein denotes N-terminal c-Jun kinase
T19 1043-1048 protein denotes HePTP
T20 1115-1125 protein denotes N terminus
T21 1131-1134 protein denotes Erk
T22 1147-1157 protein denotes MAP kinase
T23 1159-1162 protein denotes p38
T24 1172-1175 protein denotes Jnk
T25 1211-1216 protein denotes HePTP
T26 1296-1307 protein denotes MAP kinases
T27 1413-1458 protein denotes nuclear dual-specific MAP kinase phosphatases

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-119 Sentence denotes Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
S2 120-376 Sentence denotes Activation of T lymphocytes to produce cytokines is regulated by the counterbalance of protein-tyrosine kinases and protein-tyrosine phosphatases, many of which have a high degree of substrate specificity because of physical association with their targets.
S3 377-632 Sentence denotes Overexpression of hematopoietic protein-tyrosine phosphatase (HePTP) results in suppression of T lymphocyte activation as measured by T cell antigen receptor-induced activation of transcription factors binding to the 5' promoter of the interleukin-2 gene.
S4 633-920 Sentence denotes Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen-activated protein (MAP) kinases Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells.
S5 921-1023 Sentence denotes In contrast, HePTP had no effects on N-terminal c-Jun kinase or on events upstream of the MAP kinases.
S6 1024-1194 Sentence denotes The specificity of HePTP correlated with its physical association through its noncatalytic N terminus with Erk and another MAP kinase, p38, but not Jnk or other proteins.
S7 1195-1459 Sentence denotes We propose that HePTP plays a negative role in antigen receptor signaling by specifically regulating MAP kinases in the cytosol and at early time points of T cell activation before the activation-induced expression of nuclear dual-specific MAP kinase phosphatases.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 34-118 NP denotes mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
C2 207-265 NP denotes protein-tyrosine kinases and protein-tyrosine phosphatases
C3 275-280 NP denotes which
C4 362-367 NP denotes their
C5 395-445 NP denotes hematopoietic protein-tyrosine phosphatase (HePTP)
C6 472-495 NP denotes T lymphocyte activation
C7 697-702 NP denotes HePTP
C8 742-747 NP denotes HePTP
C9 765-819 NP denotes the mitogen-activated protein (MAP) kinases Erk1 and 2
C10 875-880 NP denotes their
C11 934-939 NP denotes HePTP
C12 1007-1022 NP denotes the MAP kinases
C13 1043-1048 NP denotes HePTP
C14 1065-1068 NP denotes its
C15 1098-1101 NP denotes its
C16 1139-1157 NP denotes another MAP kinase
C17 1159-1162 NP denotes p38
C18 1211-1216 NP denotes HePTP
C19 1351-1368 NP denotes T cell activation
R1 C3 C2 coref-pron which,protein-tyrosine kinases and protein-tyrosine phosphatases
R2 C4 C2 coref-pron their,protein-tyrosine kinases and protein-tyrosine phosphatases
R3 C5 C1 coref-ident hematopoietic protein-tyrosine phosphatase (HePTP),mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)
R4 C7 C5 coref-ident HePTP,hematopoietic protein-tyrosine phosphatase (HePTP)
R5 C8 C7 coref-ident HePTP,HePTP
R6 C10 C9 coref-pron their,the mitogen-activated protein (MAP) kinases Erk1 and 2
R7 C11 C8 coref-ident HePTP,HePTP
R8 C12 C9 coref-ident the MAP kinases,the mitogen-activated protein (MAP) kinases Erk1 and 2
R9 C13 C11 coref-ident HePTP,HePTP
R10 C14 C13 coref-pron its,HePTP
R11 C15 C13 coref-pron its,HePTP
R12 C17 C16 coref-appos p38,another MAP kinase
R13 C18 C13 coref-ident HePTP,HePTP
R14 C19 C6 coref-ident T cell activation,T lymphocyte activation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-30 other_name denotes T cell signaling
T2 34-66 protein_family_or_group denotes mitogen-activated protein kinase
T3 76-89 protein_molecule denotes hematopoietic
T4 90-98 amino_acid_monomer denotes tyrosine
T5 112-117 protein_molecule denotes HePTP
T6 134-147 cell_type denotes T lymphocytes
T7 159-168 protein_family_or_group denotes cytokines
T8 207-215 protein_family_or_group denotes protein-
T9 215-223 amino_acid_monomer denotes tyrosine
T10 244-252 amino_acid_monomer denotes tyrosine
T11 336-356 other_name denotes physical association
T12 395-417 protein_molecule denotes hematopoietic protein-
T13 417-425 amino_acid_monomer denotes tyrosine
T14 439-444 protein_molecule denotes HePTP
T15 472-495 other_name denotes T lymphocyte activation
T16 511-534 protein_family_or_group denotes T cell antigen receptor
T17 557-578 protein_family_or_group denotes transcription factors
T18 594-605 DNA_domain_or_region denotes 5' promoter
T19 613-631 DNA_domain_or_region denotes interleukin-2 gene
T20 697-702 protein_molecule denotes HePTP
T21 742-747 protein_molecule denotes HePTP
T22 769-808 protein_family_or_group denotes mitogen-activated protein (MAP) kinases
T23 905-919 cell_type denotes intact T cells
T24 934-939 protein_molecule denotes HePTP
T25 958-981 protein_molecule denotes N-terminal c-Jun kinase
T26 1043-1048 protein_molecule denotes HePTP
T27 1115-1125 protein_domain_or_region denotes N terminus
T28 1131-1134 protein_family_or_group denotes Erk
T29 1147-1157 protein_family_or_group denotes MAP kinase
T30 1159-1162 protein_molecule denotes p38
T31 1172-1175 protein_molecule denotes Jnk
T32 1211-1216 protein_molecule denotes HePTP
T33 1296-1307 protein_family_or_group denotes MAP kinases
T34 1315-1322 cell_component denotes cytosol
T35 1351-1368 other_name denotes T cell activation
T36 1380-1409 other_name denotes activation-induced expression
T37 1413-1458 protein_family_or_group denotes nuclear dual-specific MAP kinase phosphatases

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 14-20 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T2 134-147 Body_part denotes T lymphocytes http://purl.obolibrary.org/obo/CL_0000084
T3 472-484 Body_part denotes T lymphocyte http://purl.obolibrary.org/obo/CL_0000084
T4 511-517 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T5 1315-1322 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T6 1351-1357 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 14-20 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 134-147 Cell denotes T lymphocytes http://purl.obolibrary.org/obo/CL:0000084
T3 472-484 Cell denotes T lymphocyte http://purl.obolibrary.org/obo/CL:0000084
T4 474-484 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T5 511-517 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T6 912-919 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T7 1351-1357 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084