PubMed:10080532
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-18 | protein | denotes | IL-4 |
| T2 | 48-63 | cell_type | denotes | human monocytes |
| T3 | 67-97 | protein | denotes | type I and type II interferons |
| T4 | 103-121 | protein | denotes | Th2-type cytokines |
| T5 | 123-136 | protein | denotes | interleukin-4 |
| T6 | 138-142 | protein | denotes | IL-4 |
| T7 | 148-162 | protein | denotes | interleukin-13 |
| T8 | 164-169 | protein | denotes | IL-13 |
| T9 | 223-238 | cell_type | denotes | human monocytes |
| T10 | 250-263 | protein | denotes | FcepsilonRIIb |
| T11 | 265-269 | protein | denotes | CD23 |
| T12 | 272-287 | protein | denotes | 15-lipoxygenase |
| T13 | 289-313 | protein | denotes | IL-1 receptor antagonist |
| T14 | 315-321 | protein | denotes | IL-1ra |
| T15 | 328-361 | protein | denotes | type I and type II IL-1 receptors |
| T16 | 363-368 | protein | denotes | IL-1R |
| T17 | 371-389 | protein | denotes | Type I interferons |
| T18 | 391-400 | protein | denotes | IFN-alpha |
| T19 | 405-413 | protein | denotes | IFN-beta |
| T20 | 419-437 | protein | denotes | type II interferon |
| T21 | 439-448 | protein | denotes | IFN-gamma |
| T22 | 486-490 | protein | denotes | IL-4 |
| T23 | 495-500 | protein | denotes | IL-13 |
| T24 | 534-538 | protein | denotes | IFNs |
| T25 | 630-650 | protein | denotes | transcription factor |
| T26 | 652-657 | protein | denotes | STAT6 |
| T27 | 659-709 | protein | denotes | signal transducer and activator of transcription-6 |
| T28 | 767-776 | cell_type | denotes | monocytes |
| T29 | 819-842 | protein | denotes | type I and type II IFNs |
| T30 | 852-856 | protein | denotes | IL-4 |
| T31 | 857-862 | protein | denotes | IL-13 |
| T32 | 957-962 | protein | denotes | STAT6 |
| T33 | 979-1002 | protein | denotes | type I and type II IFNs |
| T34 | 1014-1018 | protein | denotes | IL-4 |
| T35 | 1019-1024 | protein | denotes | IL-13 |
| T36 | 1033-1038 | protein | denotes | STAT6 |
| T37 | 1098-1107 | cell_type | denotes | monocytes |
| T38 | 1116-1120 | protein | denotes | IFNs |
| T39 | 1148-1159 | cell_type | denotes | fibroblasts |
| T40 | 1175-1180 | protein | denotes | STAT6 |
| T41 | 1240-1243 | protein | denotes | IFN |
| T42 | 1268-1272 | protein | denotes | IL-4 |
| T43 | 1438-1447 | cell_type | denotes | monocytes |
| T44 | 1451-1454 | protein | denotes | IFN |
| T45 | 1489-1506 | protein | denotes | inhibitory factor |
| T46 | 1544-1569 | protein | denotes | SOCS/ SSI/CIS gene family |
| T47 | 1608-1613 | protein | denotes | STAT6 |
| T48 | 1617-1621 | protein | denotes | IL-4 |
| T49 | 1626-1631 | protein | denotes | IL-13 |
| T50 | 1641-1646 | protein | denotes | STAT6 |
| T51 | 1685-1689 | protein | denotes | IL-4 |
| T52 | 1690-1695 | protein | denotes | IL-13 |
| T53 | 1736-1744 | protein | denotes | IFN-beta |
| T54 | 1749-1758 | protein | denotes | IFN-gamma |
| T55 | 1770-1775 | protein | denotes | STAT6 |
| T56 | 1817-1821 | protein | denotes | IFNs |
| T57 | 1835-1839 | protein | denotes | IL-4 |
| T58 | 1840-1845 | protein | denotes | IL-13 |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 48-63 | NP | denotes | human monocytes |
| C2 | 67-97 | NP | denotes | type I and type II interferons |
| C3 | 99-121 | NP | denotes | The Th2-type cytokines |
| C4 | 123-170 | NP | denotes | interleukin-4 (IL-4) and interleukin-13 (IL-13) |
| C6 | 223-238 | NP | denotes | human monocytes |
| C5 | 193-369 | NP | denotes | a distinct subset of genes in human monocytes, including FcepsilonRIIb (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and type I and type II IL-1 receptors (IL-1R) |
| C8 | 419-449 | NP | denotes | type II interferon (IFN-gamma) |
| C7 | 371-449 | NP | denotes | Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) |
| C9 | 471-482 | NP | denotes | these genes |
| C10 | 486-500 | NP | denotes | IL-4 and IL-13 |
| C11 | 511-524 | NP | denotes | the mechanism |
| C12 | 528-533 | NP | denotes | which |
| C13 | 534-538 | NP | denotes | IFNs |
| C14 | 626-650 | NP | denotes | the transcription factor |
| C15 | 652-710 | NP | denotes | STAT6 (signal transducer and activator of transcription-6) |
| C16 | 767-776 | NP | denotes | monocytes |
| C17 | 794-813 | NP | denotes | our recent findings |
| C18 | 814-818 | NP | denotes | that |
| C19 | 819-842 | NP | denotes | type I and type II IFNs |
| C20 | 852-888 | NP | denotes | IL-4/IL-13-inducible gene expression |
| C21 | 957-962 | NP | denotes | STAT6 |
| C22 | 979-1002 | NP | denotes | type I and type II IFNs |
| C23 | 1098-1107 | NP | denotes | monocytes |
| C24 | 1116-1120 | NP | denotes | IFNs |
| C25 | 1175-1189 | NP | denotes | STAT6 activity |
| C26 | 1240-1243 | NP | denotes | IFN |
| C27 | 1406-1413 | NP | denotes | a model |
| C28 | 1417-1422 | NP | denotes | which |
| C29 | 1438-1447 | NP | denotes | monocytes |
| C30 | 1451-1454 | NP | denotes | IFN |
| C32 | 1608-1613 | NP | denotes | STAT6 |
| C31 | 1594-1613 | NP | denotes | activation of STAT6 |
| C33 | 1617-1631 | NP | denotes | IL-4 and IL-13 |
| C34 | 1641-1657 | NP | denotes | STAT6 activation |
| C35 | 1685-1719 | NP | denotes | IL-4/IL-13-induced gene expression |
| C36 | 1749-1758 | NP | denotes | IFN-gamma |
| C37 | 1770-1784 | NP | denotes | STAT6 activity |
| C38 | 1817-1821 | NP | denotes | IFNs |
| C39 | 1835-1871 | NP | denotes | IL-4/IL-13-inducible gene expression |
| R1 | C4 | C3 | coref-appos | interleukin-4 (IL-4) and interleukin-13 (IL-13),The Th2-type cytokines |
| R2 | C6 | C1 | coref-ident | human monocytes,human monocytes |
| R3 | C7 | C2 | coref-ident | Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma),type I and type II interferons |
| R4 | C9 | C5 | coref-ident | these genes,"a distinct subset of genes in human monocytes, including FcepsilonRIIb (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and type I and type II IL-1 receptors (IL-1R)" |
| R5 | C10 | C3 | coref-ident | IL-4 and IL-13,The Th2-type cytokines |
| R6 | C12 | C11 | coref-relat | which,the mechanism |
| R7 | C13 | C7 | coref-ident | IFNs,Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) |
| R8 | C15 | C14 | coref-appos | STAT6 (signal transducer and activator of transcription-6),the transcription factor |
| R9 | C16 | C6 | coref-ident | monocytes,human monocytes |
| R10 | C18 | C17 | coref-relat | that,our recent findings |
| R11 | C19 | C7 | coref-ident | type I and type II IFNs,Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) |
| R12 | C21 | C14 | coref-ident | STAT6,the transcription factor |
| R13 | C22 | C19 | coref-ident | type I and type II IFNs,type I and type II IFNs |
| R14 | C23 | C16 | coref-ident | monocytes,monocytes |
| R15 | C24 | C22 | coref-ident | IFNs,type I and type II IFNs |
| R16 | C26 | C24 | coref-ident | IFN,IFNs |
| R17 | C28 | C27 | coref-relat | which,a model |
| R18 | C29 | C23 | coref-ident | monocytes,monocytes |
| R19 | C30 | C26 | coref-ident | IFN,IFN |
| R20 | C32 | C21 | coref-ident | STAT6,STAT6 |
| R21 | C33 | C10 | coref-ident | IL-4 and IL-13,IL-4 and IL-13 |
| R22 | C34 | C31 | coref-ident | STAT6 activation,activation of STAT6 |
| R23 | C35 | C20 | coref-ident | IL-4/IL-13-induced gene expression,IL-4/IL-13-inducible gene expression |
| R24 | C36 | C8 | coref-ident | IFN-gamma,type II interferon (IFN-gamma) |
| R25 | C37 | C25 | coref-ident | STAT6 activity,STAT6 activity |
| R26 | C38 | C30 | coref-ident | IFNs,IFN |
| R27 | C39 | C35 | coref-ident | IL-4/IL-13-inducible gene expression,IL-4/IL-13-induced gene expression |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 14-33 | cui:C1334119 | denotes | IL-4-inducible gene |
| E2-ti-1 | 34-44 | cui:C0185117 | denotes | expression |
| E3-ti-1 | 48-53 | cui:C0020114 | denotes | human |
| E4-ti-1 | 54-63 | cui:C0026473 | denotes | monocytes |
| E5-ti-1 | 67-71 | cui:C1547052 | denotes | type |
| E6-ti-1 | 78-97 | cui:C0021745 | denotes | type II interferons |
| T1 | 34-44 | PART_OF | denotes | expression |
| T2 | 48-63 | PART_OF | denotes | human monocytes |
| E1-ab-1 | 107-111 | cui:C1547052 | denotes | type |
| E2-ab-1 | 112-121 | cui:C0079189 | denotes | cytokines |
| E3-ab-1 | 123-136 | cui:C0021758 | denotes | interleukin-4 |
| E4-ab-1 | 148-162 | cui:C0214743 | denotes | interleukin-13 |
| E5-ab-1 | 179-189 | cui:C0185117 | denotes | expression |
| E6-ab-1 | 214-219 | cui:C0017337 | denotes | genes |
| E7-ab-1 | 223-228 | cui:C0020114 | denotes | human |
| E8-ab-1 | 229-238 | cui:C0026473 | denotes | monocytes |
| E9-ab-1 | 265-269 | cui:C0123242 | denotes | CD23 |
| E10-ab-1 | 275-287 | cui:C0023837 | denotes | lipoxygenase |
| E11-ab-1 | 289-302 | cui:C0063710 | denotes | IL-1 receptor |
| E12-ab-1 | 328-332 | cui:C1547052 | denotes | type |
| E13-ab-1 | 339-346 | cui:C0441730 | denotes | type II |
| E14-ab-1 | 347-361 | cui:C0063710 | denotes | IL-1 receptors |
| T3 | 179-189 | PART_OF | denotes | expression |
| T4 | 223-238 | PART_OF | denotes | human monocytes |
| T5 | 303-313 | INHIBITS | denotes | antagonist |
| E1-ab-2 | 371-375 | cui:C1547052 | denotes | Type |
| E2-ab-2 | 378-389 | cui:C0021747 | denotes | interferons |
| E3-ab-2 | 391-400 | cui:C1610033 | denotes | IFN-alpha |
| E4-ab-2 | 405-413 | cui:C0015980 | denotes | IFN-beta |
| E5-ab-2 | 419-437 | cui:C0021745 | denotes | type II interferon |
| E6-ab-2 | 439-442 | cui:C0733470 | denotes | IFN |
| E7-ab-2 | 458-467 | cui:C0857127 | denotes | induction |
| E8-ab-2 | 477-482 | cui:C0017337 | denotes | genes |
| E9-ab-2 | 486-490 | cui:C0021758 | denotes | IL-4 |
| E10-ab-2 | 495-500 | cui:C0214743 | denotes | IL-13 |
| T6 | 378-400 | ISA | denotes | interferons (IFN-alpha |
| T7 | 378-400 | ISA | denotes | interferons (IFN-alpha |
| T8 | 378-400 | ISA | denotes | interferons (IFN-alpha |
| T9 | 458-467 | STIMULATES | denotes | induction |
| E1-ab-3 | 515-524 | cui:C0441712 | denotes | mechanism |
| E2-ab-3 | 534-538 | cui:C0733470 | denotes | IFNs |
| E3-ab-3 | 567-570 | cui:C1518422 | denotes | not |
| E1-ab-4 | 593-601 | cui:C0814812 | denotes | overview |
| E2-ab-4 | 618-622 | cui:C0035820 | denotes | role |
| E3-ab-4 | 630-650 | cui:C0040648 | denotes | transcription factor |
| E4-ab-4 | 652-657 | cui:C1335877 | denotes | STAT6 |
| E5-ab-4 | 666-676 | cui:C0040661 | denotes | transducer |
| E6-ab-4 | 694-707 | cui:C0040649 | denotes | transcription |
| E7-ab-4 | 724-728 | cui:C0021758 | denotes | IL-4 |
| E8-ab-4 | 740-747 | cui:C0205263 | denotes | induced |
| E9-ab-4 | 734-752 | cui:C1334103 | denotes | IL-13-induced gene |
| E10-ab-4 | 753-763 | cui:C0185117 | denotes | expression |
| E11-ab-4 | 767-776 | cui:C0026473 | denotes | monocytes |
| T10 | 618-622 | AFFECTS | denotes | role |
| T11 | 618-622 | AFFECTS | denotes | role |
| E1-ab-5 | 798-804 | cui:C0332185 | denotes | recent |
| E2-ab-5 | 805-813 | cui:C0243095 | denotes | findings |
| E3-ab-5 | 819-823 | cui:C1547052 | denotes | type |
| E4-ab-5 | 830-837 | cui:C0441730 | denotes | type II |
| E5-ab-5 | 838-842 | cui:C0733470 | denotes | IFNs |
| E6-ab-5 | 857-877 | cui:C1334119 | denotes | IL-13-inducible gene |
| E7-ab-5 | 878-888 | cui:C0185117 | denotes | expression |
| E8-ab-5 | 892-902 | cui:C0311403 | denotes | inhibiting |
| E9-ab-5 | 903-927 | cui:C1519726 | denotes | tyrosine phosphorylation |
| E10-ab-5 | 932-953 | cui:C1518440 | denotes | nuclear translocation |
| E11-ab-5 | 957-962 | cui:C1335877 | denotes | STAT6 |
| T12 | 843-851 | INHIBITS | denotes | suppress |
| E1-ab-6 | 968-975 | cui:C0085732 | denotes | ability |
| E2-ab-6 | 979-983 | cui:C1547052 | denotes | type |
| E3-ab-6 | 990-997 | cui:C0441730 | denotes | type II |
| E4-ab-6 | 998-1002 | cui:C0733470 | denotes | IFNs |
| E5-ab-6 | 1019-1024 | cui:C0214743 | denotes | IL-13 |
| E6-ab-6 | 1025-1032 | cui:C0205263 | denotes | induced |
| E7-ab-6 | 1033-1038 | cui:C1335877 | denotes | STAT6 |
| E8-ab-6 | 1039-1047 | cui:C0439167 | denotes | activity |
| E9-ab-6 | 1051-1055 | cui:C1446466 | denotes | dose |
| E10-ab-6 | 1061-1066 | cui:C0040223 | denotes | time- |
| E11-ab-6 | 1084-1087 | cui:C1518422 | denotes | not |
| E12-ab-6 | 1098-1107 | cui:C0026473 | denotes | monocytes |
| E13-ab-6 | 1116-1120 | cui:C0733470 | denotes | IFNs |
| E14-ab-6 | 1132-1136 | cui:C0445247 | denotes | same |
| E15-ab-6 | 1137-1144 | cui:C1280500 | denotes | effects |
| E16-ab-6 | 1148-1159 | cui:C0016030 | denotes | fibroblasts |
| T13 | 1006-1013 | INHIBITS | denotes | inhibit |
| T14 | 1145-1147 | LOCATION_OF | denotes | in |
| E1-ab-7 | 1175-1180 | cui:C1335877 | denotes | STAT6 |
| E2-ab-7 | 1181-1189 | cui:C0439167 | denotes | activity |
| E3-ab-7 | 1193-1196 | cui:C1518422 | denotes | not |
| E4-ab-7 | 1212-1217 | cui:C0007634 | denotes | cells |
| E5-ab-7 | 1240-1243 | cui:C0733470 | denotes | IFN |
| E6-ab-7 | 1268-1272 | cui:C0021758 | denotes | IL-4 |
| E7-ab-7 | 1273-1284 | cui:C1292856 | denotes | stimulation |
| T15 | 1235-1239 | PART_OF | denotes | with |
| T16 | 1273-1284 | STIMULATES | denotes | stimulation |
| E1-ab-8 | 1328-1341 | cui:C0010934 | denotes | actinomycin D |
| E2-ab-8 | 1356-1367 | cui:C1514873 | denotes | requirement |
| E3-ab-8 | 1372-1379 | cui:C1515568 | denotes | de novo |
| E4-ab-8 | 1380-1393 | cui:C0040649 | denotes | transcription |
| E1-ab-9 | 1408-1413 | cui:C0026336 | denotes | model |
| E2-ab-9 | 1423-1434 | cui:C1292856 | denotes | stimulation |
| E3-ab-9 | 1438-1447 | cui:C0026473 | denotes | monocytes |
| E4-ab-9 | 1451-1454 | cui:C0733470 | denotes | IFN |
| E5-ab-9 | 1465-1472 | cui:C1515568 | denotes | de novo |
| E6-ab-9 | 1473-1482 | cui:C0869032 | denotes | synthesis |
| E7-ab-9 | 1489-1499 | cui:C0243077 | denotes | inhibitory |
| E8-ab-9 | 1500-1506 | cui:C1521761 | denotes | factor |
| E9-ab-9 | 1508-1516 | cui:C0332149 | denotes | possibly |
| E10-ab-9 | 1517-1520 | cui:C0205447 | denotes | one |
| E11-ab-9 | 1524-1528 | cui:C0205172 | denotes | more |
| E12-ab-9 | 1529-1536 | cui:C0680022 | denotes | members |
| E13-ab-9 | 1544-1548 | cui:C0299250 | denotes | SOCS |
| E14-ab-9 | 1558-1569 | cui:C1517488 | denotes | gene family |
| E15-ab-9 | 1582-1593 | cui:C1260953 | denotes | suppressing |
| E16-ab-9 | 1608-1613 | cui:C1335877 | denotes | STAT6 |
| E17-ab-9 | 1617-1621 | cui:C0021758 | denotes | IL-4 |
| E18-ab-9 | 1626-1631 | cui:C0214743 | denotes | IL-13 |
| T17 | 1423-1434 | AUGMENTS | denotes | stimulation |
| T18 | 1594-1604 | STIMULATES | denotes | activation |
| E1-ab-10 | 1641-1646 | cui:C1335877 | denotes | STAT6 |
| E2-ab-10 | 1667-1676 | cui:C0205224 | denotes | essential |
| E3-ab-10 | 1677-1681 | cui:C0035820 | denotes | role |
| E4-ab-10 | 1696-1703 | cui:C0205263 | denotes | induced |
| E5-ab-10 | 1690-1708 | cui:C1334103 | denotes | IL-13-induced gene |
| E6-ab-10 | 1709-1719 | cui:C0185117 | denotes | expression |
| E7-ab-10 | 1725-1732 | cui:C0085732 | denotes | ability |
| E8-ab-10 | 1736-1744 | cui:C0015980 | denotes | IFN-beta |
| E9-ab-10 | 1749-1752 | cui:C0733470 | denotes | IFN |
| E10-ab-10 | 1770-1775 | cui:C1335877 | denotes | STAT6 |
| E11-ab-10 | 1776-1784 | cui:C0439167 | denotes | activity |
| E12-ab-10 | 1797-1808 | cui:C0681841 | denotes | explanation |
| E13-ab-10 | 1817-1821 | cui:C0733470 | denotes | IFNs |
| E14-ab-10 | 1840-1860 | cui:C1334119 | denotes | IL-13-inducible gene |
| E15-ab-10 | 1861-1871 | cui:C0185117 | denotes | expression |
| T19 | 1677-1681 | INTERACTS_WITH | denotes | role |
| T20 | 1826-1834 | INHIBITS | denotes | suppress |
| R1 | E1-ti-1 | T1 | subjectOf | IL-4-inducible gene,expression |
| R2 | E4-ti-1 | T1 | objectOf | monocytes,expression |
| R3 | E4-ti-1 | T2 | subjectOf | monocytes,human monocytes |
| R4 | E3-ti-1 | T2 | objectOf | human,human monocytes |
| R5 | E6-ab-1 | T3 | subjectOf | genes,expression |
| R6 | E8-ab-1 | T3 | objectOf | monocytes,expression |
| R7 | E8-ab-1 | T4 | subjectOf | monocytes,human monocytes |
| R8 | E7-ab-1 | T4 | objectOf | human,human monocytes |
| R9 | E10-ab-1 | T5 | subjectOf | lipoxygenase,antagonist |
| R10 | E11-ab-1 | T5 | objectOf | IL-1 receptor,antagonist |
| R11 | E3-ab-2 | T6 | subjectOf | IFN-alpha,interferons (IFN-alpha |
| R12 | E2-ab-2 | T6 | objectOf | interferons,interferons (IFN-alpha |
| R13 | E5-ab-2 | T7 | subjectOf | type II interferon,interferons (IFN-alpha |
| R14 | E2-ab-2 | T7 | objectOf | interferons,interferons (IFN-alpha |
| R15 | E4-ab-2 | T8 | subjectOf | IFN-beta,interferons (IFN-alpha |
| R16 | E2-ab-2 | T8 | objectOf | interferons,interferons (IFN-alpha |
| R17 | E9-ab-2 | T9 | subjectOf | IL-4,induction |
| R18 | E8-ab-2 | T9 | objectOf | genes,induction |
| R19 | E9-ab-4 | T10 | subjectOf | IL-13-induced gene,role |
| R20 | E11-ab-4 | T10 | objectOf | monocytes,role |
| R21 | E7-ab-4 | T11 | subjectOf | IL-4,role |
| R22 | E11-ab-4 | T11 | objectOf | monocytes,role |
| R23 | E5-ab-5 | T12 | subjectOf | IFNs,suppress |
| R24 | E6-ab-5 | T12 | objectOf | IL-13-inducible gene,suppress |
| R25 | E4-ab-6 | T13 | subjectOf | IFNs,inhibit |
| R26 | E7-ab-6 | T13 | objectOf | STAT6,inhibit |
| R27 | E16-ab-6 | T14 | subjectOf | fibroblasts,in |
| R28 | E13-ab-6 | T14 | objectOf | IFNs,in |
| R29 | E5-ab-7 | T15 | subjectOf | IFN,with |
| R30 | E4-ab-7 | T15 | objectOf | cells,with |
| R31 | E1-ab-7 | T16 | subjectOf | STAT6,stimulation |
| R32 | E6-ab-7 | T16 | objectOf | IL-4,stimulation |
| R33 | E4-ab-9 | T17 | subjectOf | IFN,stimulation |
| R34 | E3-ab-9 | T17 | objectOf | monocytes,stimulation |
| R35 | E17-ab-9 | T18 | subjectOf | IL-4,activation |
| R36 | E16-ab-9 | T18 | objectOf | STAT6,activation |
| R37 | E8-ab-10 | T19 | subjectOf | IFN-beta,role |
| R38 | E5-ab-10 | T19 | objectOf | IL-13-induced gene,role |
| R39 | E13-ab-10 | T20 | subjectOf | IFNs,suppress |
| R40 | E14-ab-10 | T20 | objectOf | IL-13-inducible gene,suppress |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-98 | Sentence | denotes | Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons. |
| S2 | 99-370 | Sentence | denotes | The Th2-type cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), induce expression of a distinct subset of genes in human monocytes, including FcepsilonRIIb (CD23), 15-lipoxygenase, IL-1 receptor antagonist (IL-1ra), and type I and type II IL-1 receptors (IL-1R). |
| S3 | 371-501 | Sentence | denotes | Type I interferons (IFN-alpha and IFN-beta) and type II interferon (IFN-gamma) inhibit induction of these genes by IL-4 and IL-13. |
| S4 | 502-584 | Sentence | denotes | However, the mechanism by which IFNs mediate this inhibition has not been defined. |
| S5 | 585-777 | Sentence | denotes | In this overview, we discuss the role of the transcription factor, STAT6 (signal transducer and activator of transcription-6) in mediating IL-4- and IL-13-induced gene expression in monocytes. |
| S6 | 778-963 | Sentence | denotes | We also discuss our recent findings that type I and type II IFNs suppress IL-4/IL-13-inducible gene expression by inhibiting tyrosine phosphorylation and nuclear translocation of STAT6. |
| S7 | 964-1160 | Sentence | denotes | The ability of type I and type II IFNs to inhibit IL-4/IL-13-induced STAT6 activity is dose- and time-dependent, and is not unique to monocytes because IFNs induce the same effects in fibroblasts. |
| S8 | 1161-1285 | Sentence | denotes | Inhibition of STAT6 activity is not evident unless cells are preincubated with IFN for at least 1 h before IL-4 stimulation. |
| S9 | 1286-1394 | Sentence | denotes | Furthermore, inhibition can be blocked by actinomycin D, indicating a requirement for de novo transcription. |
| S10 | 1395-1632 | Sentence | denotes | We propose a model in which stimulation of monocytes by IFN activates de novo synthesis of an inhibitory factor, possibly one or more members of the SOCS/ SSI/CIS gene family, capable of suppressing activation of STAT6 by IL-4 and IL-13. |
| S11 | 1633-1872 | Sentence | denotes | Because STAT6 activation plays an essential role in IL-4/IL-13-induced gene expression, the ability of IFN-beta and IFN-gamma to inhibit STAT6 activity provides an explanation for how IFNs can suppress IL-4/IL-13-inducible gene expression. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 14-18 | protein_molecule | denotes | IL-4 |
| T2 | 48-63 | cell_type | denotes | human monocytes |
| T3 | 103-121 | protein_family_or_group | denotes | Th2-type cytokines |
| T4 | 123-136 | protein_molecule | denotes | interleukin-4 |
| T5 | 138-142 | protein_molecule | denotes | IL-4 |
| T6 | 148-162 | protein_molecule | denotes | interleukin-13 |
| T7 | 164-169 | protein_molecule | denotes | IL-13 |
| T8 | 223-238 | cell_type | denotes | human monocytes |
| T9 | 250-263 | protein_molecule | denotes | FcepsilonRIIb |
| T10 | 265-269 | protein_molecule | denotes | CD23 |
| T11 | 272-287 | protein_molecule | denotes | 15-lipoxygenase |
| T12 | 289-313 | protein_molecule | denotes | IL-1 receptor antagonist |
| T13 | 315-321 | protein_molecule | denotes | IL-1ra |
| T14 | 363-368 | protein_family_or_group | denotes | IL-1R |
| T15 | 371-389 | protein_family_or_group | denotes | Type I interferons |
| T16 | 391-400 | protein_molecule | denotes | IFN-alpha |
| T17 | 405-413 | protein_molecule | denotes | IFN-beta |
| T18 | 419-437 | protein_family_or_group | denotes | type II interferon |
| T19 | 439-448 | protein_molecule | denotes | IFN-gamma |
| T20 | 486-490 | protein_molecule | denotes | IL-4 |
| T21 | 495-500 | protein_molecule | denotes | IL-13 |
| T22 | 534-538 | protein_family_or_group | denotes | IFNs |
| T23 | 630-650 | protein_family_or_group | denotes | transcription factor |
| T24 | 652-657 | protein_molecule | denotes | STAT6 |
| T25 | 659-709 | protein_molecule | denotes | signal transducer and activator of transcription-6 |
| T26 | 767-776 | cell_type | denotes | monocytes |
| T27 | 852-856 | protein_molecule | denotes | IL-4 |
| T28 | 857-862 | protein_molecule | denotes | IL-13 |
| T29 | 903-911 | amino_acid_monomer | denotes | tyrosine |
| T30 | 932-953 | other_name | denotes | nuclear translocation |
| T31 | 957-962 | protein_molecule | denotes | STAT6 |
| T32 | 1014-1018 | protein_molecule | denotes | IL-4 |
| T33 | 1019-1024 | protein_molecule | denotes | IL-13 |
| T34 | 1033-1038 | protein_molecule | denotes | STAT6 |
| T35 | 1098-1107 | cell_type | denotes | monocytes |
| T36 | 1116-1120 | protein_family_or_group | denotes | IFNs |
| T37 | 1148-1159 | cell_type | denotes | fibroblasts |
| T38 | 1175-1180 | protein_molecule | denotes | STAT6 |
| T39 | 1240-1243 | protein_family_or_group | denotes | IFN |
| T40 | 1268-1272 | protein_molecule | denotes | IL-4 |
| T41 | 1328-1341 | other_organic_compound | denotes | actinomycin D |
| T42 | 1372-1393 | other_name | denotes | de novo transcription |
| T43 | 1438-1447 | cell_type | denotes | monocytes |
| T44 | 1451-1454 | protein_family_or_group | denotes | IFN |
| T45 | 1465-1482 | other_name | denotes | de novo synthesis |
| T46 | 1489-1506 | protein_family_or_group | denotes | inhibitory factor |
| T47 | 1544-1569 | protein_family_or_group | denotes | SOCS/ SSI/CIS gene family |
| T48 | 1582-1604 | other_name | denotes | suppressing activation |
| T49 | 1608-1613 | protein_molecule | denotes | STAT6 |
| T50 | 1617-1621 | protein_molecule | denotes | IL-4 |
| T51 | 1626-1631 | protein_molecule | denotes | IL-13 |
| T52 | 1641-1646 | protein_molecule | denotes | STAT6 |
| T53 | 1685-1689 | protein_molecule | denotes | IL-4 |
| T54 | 1690-1695 | protein_molecule | denotes | IL-13 |
| T55 | 1736-1744 | protein_molecule | denotes | IFN-beta |
| T56 | 1749-1758 | protein_molecule | denotes | IFN-gamma |
| T57 | 1770-1775 | protein_molecule | denotes | STAT6 |
| T58 | 1817-1821 | protein_family_or_group | denotes | IFNs |
| T59 | 1835-1839 | protein_molecule | denotes | IL-4 |
| T60 | 1840-1845 | protein_molecule | denotes | IL-13 |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 224-229 | C0086418 | denotes | uman |
| T2 | 49-54 | C0086418 | denotes | uman |
| T3 | 420-438 | C0021745 | denotes | ype II interferon |
| T4 | 79-98 | C0021745 | denotes | ype II interferons. |
| T5 | 1439-1448 | C0026473 | denotes | onocytes |
| T6 | 1099-1108 | C0026473 | denotes | onocytes |
| T7 | 768-777 | C0026473 | denotes | onocytes. |
| T8 | 230-239 | C0026473 | denotes | onocytes, |
| T9 | 55-64 | C0026473 | denotes | onocytes |
| T10 | 1847-1856 | C0669372 | denotes | nducible |
| T11 | 864-873 | C0669372 | denotes | nducible |
| T12 | 20-29 | C0669372 | denotes | nducible |
| T13 | 980-986 | C0441729 | denotes | ype I |
| T14 | 820-826 | C0441729 | denotes | ype I |
| T15 | 329-335 | C0441729 | denotes | ype I |
| T16 | 68-74 | C0441729 | denotes | ype I |
| T17 | 1300-1310 | C1628982 | denotes | nhibition |
| T18 | 1162-1172 | C1628982 | denotes | nhibition |
| T19 | 553-563 | C1628982 | denotes | nhibition |
| T20 | 1-11 | C1628982 | denotes | nhibition |
| T21 | 879-889 | C0185117 | denotes | xpression |
| T22 | 754-764 | C0185117 | denotes | xpression |
| T23 | 35-45 | C0185117 | denotes | xpression |
| T24 | 1618-1622 | C0021758 | denotes | L-4 |
| T25 | 1269-1272 | C0021758 | denotes | L-4 |
| T26 | 725-729 | C0021758 | denotes | L-4- |
| T27 | 487-491 | C0021758 | denotes | L-4 |
| T28 | 124-137 | C0021758 | denotes | nterleukin-4 |
| T29 | 1627-1632 | C0214743 | denotes | L-13. |
| T30 | 1015-1025 | C0214743 | denotes | L-4/IL-13- |
| T31 | 496-501 | C0214743 | denotes | L-13. |
| T32 | 149-163 | C0214743 | denotes | nterleukin-13 |
| T33 | 1737-1745 | C0015980 | denotes | FN-beta |
| T34 | 406-414 | C0015980 | denotes | FN-beta) |
| T35 | 1763-1770 | C0018790 | denotes | nhibit |
| T36 | 1007-1014 | C0018790 | denotes | nhibit |
| T37 | 451-458 | C0018790 | denotes | nhibit |
| T38 | 273-288 | C0003692 | denotes | 5-lipoxygenase, |
| T39 | 1609-1614 | C1335877 | denotes | TAT6 |
| T40 | 1176-1181 | C1335877 | denotes | TAT6 |
| T41 | 1034-1038 | C1335877 | denotes | TAT6 |
| T42 | 958-963 | C1335877 | denotes | TAT6. |
| T43 | 653-658 | C1335877 | denotes | TAT6 |
| T44 | 1726-1733 | C0085732 | denotes | bility |
| T45 | 969-976 | C0085732 | denotes | bility |
| T46 | 1490-1500 | C3463820 | denotes | nhibitory |
| T47 | 893-903 | C3463820 | denotes | nhibiting |
| T48 | 348-362 | C0063710 | denotes | L-1 receptors |
| T49 | 290-294 | C0600251 | denotes | L-1 |
| T50 | 372-390 | C0021743 | denotes | ype I interferons |
| T51 | 1260-1261 | C0033727 | denotes | |
| T52 | 1122-1128 | C0205263 | denotes | nduce |
| T53 | 1026-1033 | C0205263 | denotes | nduced |
| T54 | 741-748 | C0205263 | denotes | nduced |
| T55 | 173-178 | C0205263 | denotes | nduce |
| T56 | 1329-1342 | C0010934 | denotes | ctinomycin D, |
| T57 | 113-122 | C0079189 | denotes | ytokines, |
| T58 | 1381-1394 | C0040649 | denotes | ranscription. |
| T59 | 1545-1549 | C0299250 | denotes | OCS/ |
| T60 | 1827-1835 | C1260953 | denotes | uppress |
| T61 | 1583-1593 | C1260953 | denotes | uppressing |
| T62 | 844-852 | C1260953 | denotes | uppress |
| T63 | 1194-1196 | C1518422 | denotes | ot |
| T64 | 1085-1088 | C1518422 | denotes | ot |
| T65 | 568-571 | C1518422 | denotes | ot |
| T66 | 1777-1785 | C1561536 | denotes | ctivity |
| T67 | 1182-1190 | C1561536 | denotes | ctivity |
| T68 | 1040-1048 | C1561536 | denotes | ctivity |
| T69 | 991-998 | C0441730 | denotes | ype II |
| T70 | 831-838 | C0441730 | denotes | ype II |
| T71 | 340-347 | C0441730 | denotes | ype II |
| T72 | 715-723 | C0086597 | denotes | ediating |
| T73 | 540-547 | C0086597 | denotes | ediate |
| T74 | 667-677 | C0040661 | denotes | ransducer |
| T75 | 1149-1160 | C0016030 | denotes | ibroblasts. |
| T76 | 1754-1759 | C1552644 | denotes | amma |
| T77 | 444-449 | C1552644 | denotes | amma) |
| T78 | 1678-1682 | C1705810 | denotes | ole |
| T79 | 619-623 | C1705810 | denotes | ole |
| T80 | 1648-1658 | C1879547 | denotes | ctivation |
| T81 | 1595-1605 | C1879547 | denotes | ctivation |
| T82 | 1424-1435 | C1292856 | denotes | timulation |
| T83 | 1274-1285 | C1292856 | denotes | timulation. |
| T84 | 1466-1473 | C1515568 | denotes | e novo |
| T85 | 1373-1380 | C1515568 | denotes | e novo |
| T86 | 1062-1066 | C0040223 | denotes | ime- |
| T87 | 1474-1483 | C0220781 | denotes | ynthesis |
| T88 | 1213-1218 | C0007634 | denotes | ells |
| T89 | 577-584 | C1704788 | denotes | efined. |
| T90 | 1659-1664 | C0600138 | denotes | lays |
| T91 | 1052-1056 | C0178602 | denotes | ose- |
| T92 | 241-249 | C0332257 | denotes | ncluding |
| T93 | 392-401 | C1610033 | denotes | FN-alpha |
| T94 | 1786-1794 | C1999230 | denotes | rovides |
| T95 | 1456-1465 | C1515877 | denotes | ctivates |
| T96 | 594-602 | C0814812 | denotes | verview, |
| T97 | 904-928 | C1519726 | denotes | yrosine phosphorylation |
| T98 | 1067-1076 | C1701901 | denotes | ependent, |
| T99 | 1518-1521 | C0205447 | denotes | ne |
| T100 | 660-666 | C1710082 | denotes | ignal |
| T101 | 806-814 | C2607943 | denotes | indings |
| T102 | 933-954 | C1518440 | denotes | uclear translocation |
| T103 | 304-314 | C0231491 | denotes | ntagonist |
| T104 | 1198-1205 | C0332120 | denotes | vident |
| T105 | 1318-1325 | C0332206 | denotes | locked |
| T106 | 1089-1095 | C1710548 | denotes | nique |
| T107 | 1138-1145 | C1280500 | denotes | ffects |
| T108 | 1798-1809 | C0681841 | denotes | xplanation |
| T109 | 516-525 | C0441712 | denotes | echanism |
| T110 | 1357-1368 | C1514873 | denotes | equirement |
| T111 | 1409-1414 | C3161035 | denotes | odel |
| T112 | 1530-1537 | C0680022 | denotes | embers |
| T113 | 1668-1677 | C0205224 | denotes | ssential |
| T114 | 1509-1516 | C2362652 | denotes | ossibly |
| T115 | 799-805 | C0332185 | denotes | ecent |
| T116 | 1572-1579 | C2698977 | denotes | apable |
| T117 | 108-112 | C0332307 | denotes | ype |
| T118 | 295-303 | C0597357 | denotes | eceptor |
| T119 | 1252-1257 | C0547044 | denotes | east |
| T120 | 1133-1137 | C0445247 | denotes | ame |
| T121 | 1501-1507 | C1521761 | denotes | actor, |
| T122 | 205-211 | C1515021 | denotes | ubset |
| T123 | 1555-1558 | C1504308 | denotes | IS |
| T124 | 1525-1529 | C0205172 | denotes | ore |