PubMed:10023074 JSONTXT

{"project":"bionlp-st-gro-2013-development","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"Enzyme"},{"id":"T2","span":{"begin":16,"end":39},"obj":"Enzyme"},{"id":"T8","span":{"begin":136,"end":140},"obj":"Enzyme"},{"id":"T9","span":{"begin":167,"end":190},"obj":"Enzyme"},{"id":"T15","span":{"begin":253,"end":259},"obj":"Enzyme"},{"id":"T16","span":{"begin":260,"end":266},"obj":"ProteinDomain"},{"id":"T17","span":{"begin":270,"end":274},"obj":"Enzyme"},{"id":"T18","span":{"begin":303,"end":313},"obj":"Enzyme"},{"id":"T20","span":{"begin":349,"end":353},"obj":"Enzyme"},{"id":"T22","span":{"begin":409,"end":411},"obj":"ProteinDomain"},{"id":"T25","span":{"begin":460,"end":464},"obj":"Protein"},{"id":"T26","span":{"begin":469,"end":476},"obj":"Protein"},{"id":"T27","span":{"begin":478,"end":487},"obj":"MessengerRNA"},{"id":"T29","span":{"begin":517,"end":532},"obj":"Tissue"},{"id":"T30","span":{"begin":534,"end":546},"obj":"Enzyme"},{"id":"T32","span":{"begin":581,"end":593},"obj":"CellComponent"},{"id":"T33","span":{"begin":633,"end":637},"obj":"Enzyme"},{"id":"T34","span":{"begin":645,"end":657},"obj":"CellComponent"},{"id":"T35","span":{"begin":668,"end":672},"obj":"Cell"},{"id":"T3","span":{"begin":59,"end":61},"obj":"ProteinDomain"},{"id":"T4","span":{"begin":88,"end":90},"obj":"ProteinDomain"},{"id":"T5","span":{"begin":118,"end":132},"obj":"ProteinIdentification"},{"id":"T6","span":{"begin":206,"end":208},"obj":"ProteinDomain"},{"id":"T7","span":{"begin":236,"end":238},"obj":"ProteinDomain"},{"id":"T10","span":{"begin":417,"end":427},"obj":"ProteinDomain"},{"id":"T11","span":{"begin":564,"end":569},"obj":"Protein"},{"id":"T12","span":{"begin":673,"end":681},"obj":"Function"},{"id":"E1","span":{"begin":334,"end":343},"obj":"CellDeath"},{"id":"E2","span":{"begin":357,"end":375},"obj":"Phosphorylation"},{"id":"E3","span":{"begin":504,"end":513},"obj":"TranscriptionOfGene"},{"id":"E4","span":{"begin":551,"end":560},"obj":"Localization"}],"relations":[{"id":"R5","pred":"hasPart","subj":"T17","obj":"T16"},{"id":"R6","pred":"locatedIn","subj":"E3","obj":"T29"},{"id":"R7","pred":"locatedIn","subj":"E4","obj":"T32"},{"id":"R1","pred":"hasPart","subj":"T1","obj":"T3"},{"id":"R2","pred":"hasPart","subj":"T1","obj":"T4"},{"id":"R3","pred":"hasPart","subj":"T8","obj":"T9"},{"id":"R4","pred":"hasPart","subj":"T8","obj":"T6"},{"id":"R8","pred":"hasPart","subj":"T8","obj":"T7"},{"id":"R10","pred":"hasAgent","subj":"T20","obj":"E2"},{"id":"R11","pred":"hasPatient","subj":"T20","obj":"E2"},{"id":"R12","pred":"hasPatient","subj":"T27","obj":"E3"},{"id":"R13","pred":"hasPatient","subj":"T30","obj":"E4"}],"text":"Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.\nWe show here the identification of Duet, a novel molecule bearing serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains. The kinase domain of Duet shows a homology to that of DAP kinase that is involved in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay. The DH- and PH-domains are closely related to those of Trio and Kalirin. Trad mRNA is specifically expressed in skeletal muscle. Duet protein was localized to actin-associated cytoskeletal elements. These data suggest a role of Duet in the cytoskeleton-dependent cell function."}