Conducting and reporting systematic reviews with the highest possible quality is likely to minimize the possibility that their results are influenced by bias, enabling clinicians to be more confident of using them in their practice. Reports of PedCAM systematic reviews seem particularly weak in terms of the comprehensiveness in their search to identify primary studies. For example, excluding a report identified uniquely in Embase, compared to its inclusion, can statistically exaggerate the estimates of an intervention's effectiveness by 6%, on average [13].