Concentrations of nutrients averaged from the FC and TC are reported in Table 2 (vitamin K only from FC). These data have also been previously reported separately for FC and TC (27, 31, 40). Lutein was the most predominant carotenoid in all FC and TC tissues with a concentration of 79.50 (52.57) pmol/g. On the contrary, lycopene, at an average concentration of 20.41 (21.38) pmol/g, was not detected in both FC and TC in 20 subjects (43% of all subjects). Retinol, which included both free retinol, retinal, and retinyl esters before hydrolyzation during lipid extraction, had a concentration of 691.97 (305.56) pmol/g. Concentrations of α-TP and γ-TP were 66,917 (13,676) and 1,742 (1,018) pmol/g, respectively. While MK-4 was detectable in all brain tissues at 4.96 (2.32) pmol/g, PK was not detected in 17 subjects (38%). The predominant class of FA in the brain samples was SFA, which accounted for 15.36 (2.30) nmol/mg or 47.93 (1.68) mol%. Concentrations of individual FAs are shown in Supplementary Table 2. Docosahexaenoic acid (DHA, 22:6 n-3) and arachidonic acid (AA, 20:4 n-6) were the most predominant n-3 PUFA (11.90 (1.60) mol% or 90.22% of total n-3 PUFAs) and n-6 PUFA (8.54 (0.57) mol% or 66.36% of total n-6 PUFAs), respectively, in all brain tissues. Concentrations of each nutrient were not significantly different among demented and demented subjects. However, total trans-FA concentration was significantly higher among demented subjects (p = 0.020).