PMC:7799378 / 17053-17902 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7799378","sourcedb":"PMC","sourceid":"7799378","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7799378","text":"Neutrophils are among the key players in the immune system. The role of neutrophils in bacterial or fungal infection is well known, yet their influence on the anti-viral response has not been established [87]. In response to infection, stimulated neutrophils release chromosomal DNA for trapping and killing invading microbes. The chromatin trap is known as the neutrophil extracellular trap (NET). It mediates the control of viruses, such as seen with human HIV and chikungunya viral infections [88, 89], whereas it can contribute to other viral infections, including in non-human primates with SIV and Hep-2 cells infected with respiratory syncytial virus [90,91]. The cytotoxic effect on lung epithelium and endothelium has linked NETs to several pulmonary diseases, including acute lung injury, asthma, COPD, cystic fibrosis, and pneumonia 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