Contributors: Conception and design of the study: LD, EBP. Acquisition of data: RDB, EBP, RW, KMET. Mathematical modelling: RDB, LM, LD, EBP, RMW, KMET. Coding and simulations: RDB. Analysis and interpretation of results: RDB, LM, LV, KJL, CH, PDB, IH, RL, FH, DL, LD, AP, EBP, RMW, KMET. Writing and drafting of the manuscript: RDB, LM, LV, KJL, CH, PDB, IH, RL, FH, DL, LD, AP, EBP, RMW, KMET. Approval of the submitted manuscript: RDB, LM, LV, KJL, CH, PDB, IH, RL, FH, DL, LD, AP, EBP, RMW, KMET.